Kelly Thomas H., Richard W. Foltin, Cleeve S. Emurian and Marian W. Fischman: Multidimensional Behavioral Effects of Marijuana. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1990,
: 885–902.
1. 1. Five groups of three healthy adult male volunteers (n = 15), all reporting occasional, controlled marijuana use, gave written consent and participated in residential studies lasting 6 to 15 days.
2. 2. Subjects smoked marijuana cigarettes (0 1.3 2.3 or 2.7% THC, w/w) at 0945, 1330, 1700 and 2030 every day, and each subject received both active and placebo marijuana cigarettes in 2–5 consecutive day phases, with placebo and active doses presented in an alternating fashion.
3. 3. In comparison with placebo, active marijuana produced a variety of effects on measures of human behavior, including
in food consumption and errors on psychomotor tasks,
in bouts of tobacco-cigarette smoking and verbal interactions and
in rates of task performance, time spent under social conditions or social cooperation.
4. 4. Dimensions of human behavior were differentially sensitive to the effects of smoked marijuana.
5. 5. The simultaneous measurement of multiple dimensions of human behavior is a useful procedure for determining dose potency following marijuana administration.
Purpose: This article explores which concrete factors hinder or facilitate the cooperation of return-to-work (RTW) professionals in a complex system of multiple stakeholders.
Method: The empirical material consists of in-depth interviews with 24 RTW professionals from various organizations involved in work disability management in Finland. The interviews were analyzed using thematic content analysis.
Results: The study revealed several kinds of challenges in the cooperation of the professionals. These were related to two partly interrelated themes: communication and distribution of responsibility. The most difficult problems were connected to the cooperation between public employment offices and other stakeholders. However, the study distinguished notable regional differences depending primarily on the scale of the local network. The main areas of improvement proposed by the interviewees were related to better networking of case managers and expansion of expertise.
Conclusions: The article argues for the importance of systematic networking and stresses the role of public employment services in the multi-actor management of work disabilities. The article contributes to existing work disability case management models by suggesting the employment administration system as an important component in addition to health care, workplace and insurance systems. The study also highlights the need for expansion of expertise in the field.
Implications for Rehabilitation
Cooperation between RTW professionals in public employment offices and other organizations involved in work disability management was considered inadequate.
In order to improve the cooperation of RTW professionals, the stakeholders need to create more systematic ways of communication and networking with professionals in other organizations.
There is a need to expand the expertise in work disability management and rehabilitation, partly by increasing the role of other professionals than physicians.
A comprehensive biometrical assessment was conducted to compare the performance of multiple test designs for acute dermal systemic toxicity to support the animal welfare update to the original OECD Test Guideline (TG) 402 for acute dermal toxicity. The test designs evaluated included: (1) two, three, or five animals per dose group (2) evident toxicity or lethality endpoints and (3) absence or presence of a one-animal sighting study. The revision of TG 402 respected the 3R principles (replace, reduce, refine) of animal testing. The results demonstrate that the TG 402 test design can be optimised with reduced animal numbers per test group, such that a scenario of two animals per group following a sighting study at a starting dose of 200 mg/kg bw (unless further information is available to better define the starting dose) would provide a classification which in most cases is conservative, without compromising both the statistical ability of the study to assess dermal toxicity, or the relevant classification outcome. 相似文献
AbstractThis study is based on data analysis by light and transmission electron microscopy of the surgical cases in cerebral tumors, cerebrovascular malformations, thromboses in the carotid system, and other injuries such as perivascular hemorrhage. We examined cortical arteries and veins, perivascular areas with old hematic masses, vasculogenic foci, and broken large vessels. We identified, characterized, and compared both undifferentiated cells and well-differentiated cordocytes within periadventitial areas where these cells cooperate very well with precursor/stem cells to perform vital functions for cerebral vasculature with immediate effect on brain parenchyma. This useful cellular cooperation was observed by serial sections pointing out the main role of cordocytes during the entire process of collateral vessel formation after thrombosis and, respectively, in vascular wall repair after ruptures. This is the first cytohistopathological study which illustrates and explains some facets of cordocytes-stem cells cooperation around the vessels of human brain with emphasis on the fundamental role of cordocytes in response to vascular injuries. Our pioneering study will be completed for both basic science and modern medical care by further studies. 相似文献
Joint action is central to countless aspects of human life. Here I examine the roots of joint action in infancy. First, I provide evidence that—contrary to popular belief—1‐year‐old infants do have the social‐cognitive prerequisites needed to participate in joint action, even in a relatively strict sense: they can read others’ goals and intentions, they have some basic understanding of common knowledge, and they have the ability and motivation to help others achieve their goals. Then I review some evidence of infants’ and young children’s active participation in different types of joint action, from prelinguistic communication to more instrumental collaborations with others, with a particular focus on whether young children show evidence of an understanding of the commitments and obligations entailed in joint action. I conclude that the uniquely human ability and motivation to participate in joint action is already seen in infants by 1 year of age. 相似文献