Zinc ions and alkaline PH alter the phosphorylated state of proteins 3 and 4.2 in human erythrocyte membranes

The phosphorylation patterns of isolated red blood cell (RBC) membranes labeled with [ γ-³²p]ATP are altered by Zn⁺⁺ ions. Zn⁺⁺ ions caused an increased phosphate incorporation into a 72 KDa protein and several proteins in the 40–60 KDa region and a decrease in the labeling of a 53 KDa protein. The 72 KDa and 53 KDa proteins have been identified as protein 4.2 and a protease-cleaved fragment of protein 3, respectively. Evidence suggests that the changes in phosphorylation pattern may be due to the stimulation of endogenous membrane alkaline phosphatase(s). Our results suggest that Zn⁺⁺, at physiological concentrations in the intact erythrocyte, could modulate the phosphorylation of selected proteins which may regulate their association in the cytoskeletal network.     

单一电铃电路条件性行为疗法在建立儿童自主排尿反射中的作用研究

本工作在于探讨单一电铃电路条件性训练在建立儿童自主排尿反射中的治疗作用。采用新型研制的电铃电路床单，将电铃声刺激与膀胱充盈刺激有效的吻合起来，夜间训练遗尿患儿清醒后自主排尿。对年龄５～１０岁，经多项检查诊断确定为功能性遗尿的患儿（男１８名，女４名）２２人施行条件性行为训练方法。临睡的铺平电铃电路床单、患儿遗尿初期浸湿床单，引起铃响（患儿不惊醒时由母亲唤醒），患儿起床自主排尿。采用阳性强化法对患儿自主排尿进行巩固，给予原发以及继发性奖赏。结果：单一电铃电路条件性训练平均１２个有效治疗日后，９４．９７％（１８／１９）患儿遗尿症状消失，其中效果最佳者仅用了３个有效治疗日，最后长的达３０个有效治疗日，２人因故中断治疗，１人治疗无效。可见，单一行为方法是一条治疗儿童功能性遗尿的有效措施。     

淡色库蚊不同发育阶段双向电泳的蛋白质多肽点图谱比较

用双向电泳分析淡色库蚊卵、二令幼虫、四令幼虫、蛹和成虫蛋白质组成.电泳完毕后,用考马斯亮兰G-250染色,结果以成蚊蛋白质多肽点为最多(116点),其次依次为蛹(101点)、卵(70点)、四令幼虫(53点)、二令幼虫(18点)。它们在不同分子量和不同PH 范围内的分布也不同,但总的来看,在幼体阶段(卵、二、四令幼虫及蛹)多偏低分子量和低PI 值的点,发育至成虫阶段,分布走向全面。     

A Ro/SS-A auto-antibody positive mother's infant revealed congenital complete atrioventricular block,followed by insulin dependent diabetes mellitus and multiple organ failure

We experienced a congenital complete atrioventricular block infant who was born from a Ro/SS-A antibody positive mother. Ro/SS-A antibody was also found in this baby which was presumed to be mediated by the maternal placenta. Temporary cardiac pacing was required at birth and pacemaker implantation was performed at 9 months. At 11 months of age, the baby fell into shock and experienced multiple organ failure because of diabetes mellitus-induced coma. The association between congenital complete heart block and the Ro/SS-A antibody is well known. However, the accompaniment of insulin-dependent diabetes mellitus has not been reported previously. As the Ro/SS-A antigen appears in the cytoplasm of many tissues, the possibility of an association between Ro/SS-A antibody and diabetes mellitus is difficult to deny. We report this rare case to draw attention to the possibility that babies who are born from an Ro/SS-A antibody positive mother may develop diabetes mellitus as well as congenital complete heart block.     

小儿中枢神经系统肿瘤71例病理分析

本文分析了1962年至1986年间的71例小儿中枢神经系统肿瘤的病理资料,该病占同期中枢神经系统肿瘤的16.6％。71例中,颅内肿瘤67例,椎管内肿瘤4例。颅内肿瘤中幕上38例,以星形细胞瘤多见,其次为先天性肿瘤。幕下29例以髓母细胞瘤多见,其次为星形细胞瘤。小儿中枢神经系统肿瘤以恶性居多,预后不佳。脑中线是肿瘤的好发区。     

The abnormal anatomy of cleft lip and its correction

Summary The importance of the premaxillary position, size and shape in the development of the face and nose is discussed. The anthropological development of the premaxilla is studied. These factors are to be considered when cleft lip repairs are being planned and developed. Several cases are presented and discussed.     

Cancer risks associated with 10 inorganic dusts: results from a case-control study in Montreal

A multicancer site, multifactor case-control study was undertaken to generate hypotheses about possible occupational carcinogens. Probing interviews were carried out with eligible cases, comprising all incident cases of 20 types of cancer who were male, aged 35-70 years, and a resident in Montreal. The interview was designed to obtain detailed lifetime job histories and information on potential confounders. Each job history was reviewed by a team of chemists and industrial hygienists who translated it into a history of occupational exposures. These occupational exposures were then analyzed as potential risk factors in relation to the sites of cancer included; 3,726 cases were interviewed. For each site of cancer analyzed, controls were selected from among the other sites in the study. This report concerns the associations between the 12 main types of cancer in our series and 10 inorganic dusts that are found mainly in construction and metal industries. All site-exposure combinations were investigated. After intensive control for confounding, nonadenocarcinoma (NAC) of the lung was associated with long duration-high level exposure to silica (odds ratio [OR] = 1.4), excavation dust (OR = 1.9), concrete dust (OR = 2.5), abrasives dust (OR = 1.4), and alumina (OR = 1.5). It was difficult to disentangle the relative effects of those substances, and confounding among them was a distinct possibility. Although residual confounding by some uncontrolled factors may explain the elevated ORs, the results were compatible with the hypothesis of a nonspecific relation between NAC of the lung and respirable inorganic dusts as a class. Other associations that remained suggestive after in-depth analysis were silica and stomach cancer (OR = 1.2) and concrete dust and lymphoma (OR = 2.9).     

Rhizomelic Bone Dysplasia with Club-like Femora (Case report and confirmation of a syndrome)

A newborn with rhizomelic bone dysplasia with club-like femora is reported. This is the fourth case Of this easily recognizable, recently reported, congenital bone disease. Maroteaux et al recently reported two patients with rhizomelic bone dysplasia and club-like femora as a distinctive new bone dysplasia. Their observation was confirmed by Gugliantini et al (2) who reported another case. This paper reports a fourth patient with this easily recognisable disorder.     

Probing the regioselective C‐deuteriation of lithium enolates derived from 2‐methyl‐tetralone in the presence of substituted tertiary amines

Results are reported on the regioselective C‐deuteriation of 2‐methyl‐tetralone using a series of D‐sources and tertiary amines as potential mediators. The results presented further aid the understanding of kinetic deuteriation of both ‘base‐containing’ and ‘base‐free’ enolates. Copyright © 2006 John Wiley & Sons, Ltd.     

开展电话回访搭建医患沟通桥梁

通过对3 500余人次的有效电话回访,实施健康教育、健康指导3000余人次,受理健康咨询500余人次,协调和化解各类医疗纠纷20余起。电话回访搭起了和谐医患关系的桥梁。