响应面法-中心复合试验优选白芍土炒工艺

目的：优选土炒白芍的炮制工艺参数。方法：以芍药苷、芍药内酯苷含量的综合评分为响应值,土炒温度、时间及加土量为自变量,通过响应面法-中心复合试验优选土炒白芍的工艺参数。采用HPLC测定芍药苷、芍药内酯苷含量,流动相乙腈-0.1%磷酸溶液（14：86）,检测波长230 nm。结果：白芍最佳土炒工艺为温度200 ℃,炒制时间11 min,饮片与灶心土用量比10：3;芍药苷和芍药内酯苷平均质量分数分别为3.198%,0.800%。结论：白芍土炒后芍药苷和芍药内酯苷含量高于生品。优选的工艺参数稳定可靠,为土炒白芍的质量控制提供参考。     

炮制条件对煅牡蛎质量影响的研究

对不同炮制条件下煅牡蛎的外观性状、收得率、总Ca含量、总成分煎出率、水煎液中Ca²⁺含量、微量元素含量等项指标进行了比较和研究,对6城市的煅牡蛎质量进行了考察。     

石决明炮制研究

目的:探讨不同炮制条件对石决明的影响.方法:比较不同炮制品的外观性状、质地、得率、总钙含量和煎出量、成分煎出率、微量元素含量.结果:不同炮制条件对石决明质量有一定影响.结论:石决明煅制品质量优于生品.煅制品中明煅制品以900℃1h为佳.煅淬品优于明煅品,本实验条件下淬液醋优于盐水.不同煅制品中微量元素有一定的变化.     

闽产鲍鱼壳中碳酸钙微量元素和氨基酸的分析

采用ＥＤＴＡ滴定法、高频电感耦合等离子体发射光谱法、酸水解法分别测定闽产鲍鱼壳中碳酸钙、微量元素及氨基酸含量。结果表明,其碳酸钙含量高达９２％,含１６种微量元素及１７种氨基酸,为开发利用闽产鲍鱼壳提供了可靠的科学依据。     

Concha bullosa: Frequency and appearances on sinonasal CT

Aeration of the middle turbinate, termed “Concha bullosa”, is one of the most common, obstructive, anatomic variants seen in patients with sinusitis. The present study was carried out on 150 patients of chronic sinusitis, who underwent CT scan paranasal sinuses, coronal section prior to Functional Endoscopic Sinus Surgery (FESS). The CT Scans were evaluated to detect the incidence of Concha bullosa and its types, the significance of Concha bullosa in genesis of osteomeatal complex disease and relation between type of Concha bullosa and osteomeatal complex disease. Later the patients were subjected to FESS. In this study we found that the overall incidence of inflammatory disease in the osteomeatal complex in these symptomatic patients was no different between with and without Concha bullosa and osteomeatal complex disease is found to be more frequent if peumatization is localized to inferior part of middle turbinate. Concha bullosa requires specific endoscopic surgical techniques.     

Assessing the efficacy of a modified crushing technique for the management of concha bullosa: a cone beam computer tomography study

IntroductionAlthough many surgical techniques exist to manage obstructive concha bullosa, there continues to be a drive to find the least invasive technique with the fewest complications and best results.ObjectivesThe purpose of this study is to describe and assess the short- and long-term efficacy of a modified crushing technique for concha bullosa management.MethodsPatients who met inclusion criteria underwent a detailed nasal examination and cone beam computed tomography imaging prior to and after septoplasty with crushing surgery for obstructive concha bullosa. Patients were divided into short- and long-term groups based on their followup period such that the short-term group had a mean followup of 15.14 months (range 6–22 months) and the long-term group had a mean followup of 56.66 (range 29–80) months.ResultsTwenty-four cases of obstructive concha bullosa were included in this study with 13 short-term and 11 long-term follow-ups. All patients showed a significantly decreased postoperative CB size (p < 0.001). There was no correlation between age and postoperative CB change in area (p = 0.39) and no significant difference in the amount of postoperative CB area reduction between the short-term and long-term groups (p = 0.35). No patients experienced bleeding, synechia, conchal destruction, or olfactory dysfunction on followup evaluations.ConclusionsOur modified crushing technique is a simple, effective, and lasting treatment option for concha bullosa. From our experience, there have been no complications and no instances of concha bullosa reformation during the follow-up period.     

清开灵注射液和珍珠母水解液中钙的测定及形态初探

目的：测定清开灵注射液（胆酸，珍珠母，水牛角，黄芩等）及其原料药材珍珠母水解液中游离钙和结合钙含量。方法：采用原子吸收分光光度法和离子色谱法进行钙含量的测定。结果：清开灵注射液及珍珠母水解液中都存在游离和结合两种状态的钙；分别在pH6.0,pH6.5,pH7.0下制备得到供试样品，清开灵注射液中结合钙与游离钙的比值分别为7.0（RSD为9.3%)，8.0(RSD为8.0%),12.1(RSD为9.2%)，珍珠母水解液中结合钙与游离钙的比值分别为4.0(RSD为12.0%),4.0(RSD为10.8%),4.1(RSD为15.7%)。结论：钙的存在状态及其含量比值是进一步规范清开灵注射液质量标准，研究清开灵治疗脑水肿机理的重要参数。     

鼻内镜下等离子消融治疗下鼻甲增生129例临床观察

下鼻甲肥大常与鼻中隔偏曲、鼻窦炎同时伴发,或作为上诉疾病的伴随症状之一.以往治疗多行下鼻甲部分切除或与中隔矫正,鼻窦手术分期进行,治疗周期长,增加患者负担.我科自2007年引进等离子消融系统,2009年11月引进鼻内镜及手术动力切割系统之后,对下鼻甲肥大及增生患者在鼻内镜下行等离子消融,并可同时治疗相关疾病,疗效显著,现总结如下.     

瓦楞子炮制历史沿革及现代研究进展

通过对古代及现代医药文献进行查阅、整理、分析,总结了瓦楞子的炮制历史沿革及现代研究概况。以《历代中药炮制资料辑要》一书为线索,查阅三国至清朝时期本草原著30部,并查阅《中国药典》9部,《全国中药炮制规范》1988年版和地方中药饮片炮制规范22部,对古今文献中所收载的瓦楞子炮制方法加以归纳、总结。瓦楞子炮制历史悠久,历代的炮制方法有生品研碎、火煅、煅醋淬、煅醋煮、煅盐水煮等,目前全国各地主要沿用了煅法。现行的炮制规范中对煅制工艺和火候的表述过于广泛,缺乏定性定量指标和统一的炮制质量标准,而且现行的质控标准主要以碳酸钙的含量作为评价指标,需进一步对炮制工艺进行研究,包括煅制火候、温度、时间、煅淬次数、粉碎粒度等具体工艺参数,并比较不同炮制工艺和炮制方法对其化学成分含量的影响,以发挥瓦楞子的最佳药物疗效。另外应进一步对瓦楞子中有机质类成分及某些微量元素进行研究,以增加其质控指标或方法,从根本上全面控制瓦楞子的内在质量。