全文获取类型
收费全文 | 32979篇 |
免费 | 3627篇 |
国内免费 | 738篇 |
专业分类
耳鼻咽喉 | 372篇 |
儿科学 | 383篇 |
妇产科学 | 386篇 |
基础医学 | 1908篇 |
口腔科学 | 9691篇 |
临床医学 | 2155篇 |
内科学 | 2448篇 |
皮肤病学 | 618篇 |
神经病学 | 523篇 |
特种医学 | 433篇 |
外国民族医学 | 1篇 |
外科学 | 1903篇 |
综合类 | 3798篇 |
现状与发展 | 3篇 |
预防医学 | 1571篇 |
眼科学 | 213篇 |
药学 | 6725篇 |
33篇 | |
中国医学 | 2640篇 |
肿瘤学 | 1540篇 |
出版年
2024年 | 84篇 |
2023年 | 608篇 |
2022年 | 821篇 |
2021年 | 1275篇 |
2020年 | 1442篇 |
2019年 | 1378篇 |
2018年 | 1336篇 |
2017年 | 1283篇 |
2016年 | 1312篇 |
2015年 | 1264篇 |
2014年 | 2121篇 |
2013年 | 2573篇 |
2012年 | 2002篇 |
2011年 | 2128篇 |
2010年 | 1637篇 |
2009年 | 1497篇 |
2008年 | 1451篇 |
2007年 | 1405篇 |
2006年 | 1277篇 |
2005年 | 1248篇 |
2004年 | 1054篇 |
2003年 | 987篇 |
2002年 | 805篇 |
2001年 | 716篇 |
2000年 | 601篇 |
1999年 | 513篇 |
1998年 | 443篇 |
1997年 | 455篇 |
1996年 | 379篇 |
1995年 | 341篇 |
1994年 | 320篇 |
1993年 | 246篇 |
1992年 | 271篇 |
1991年 | 202篇 |
1990年 | 191篇 |
1989年 | 192篇 |
1988年 | 163篇 |
1987年 | 146篇 |
1986年 | 123篇 |
1985年 | 153篇 |
1984年 | 136篇 |
1983年 | 99篇 |
1982年 | 123篇 |
1981年 | 114篇 |
1980年 | 83篇 |
1979年 | 63篇 |
1978年 | 51篇 |
1977年 | 64篇 |
1976年 | 46篇 |
1975年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
131.
本文报导采用过氧化氢液在急性阑尾炎术对局部腹腔及切口进行冲洗的方法。并用50个病例进行了对比分析。认为此法简单、可靠。对腹腔脓肿,预防切口感染有一定效果。可适用于一般基层医院。 相似文献
132.
Vijay Tumuluri Graham A. Thomas Ian S. Fraser 《Journal of oral pathology & medicine》2004,33(4):204-208
BACKGROUND: We hypothesise that the density of proliferating cells at the invasive tumour front (ITF) has a positive relationship with prognostic and risk factors in human oral squamous cell carcinoma (SCC). METHODS: Tissues from 47 human oral SCC specimens were collected and stained with a monoclonal antibody directed against the Ki-67 antigen using a horseradish peroxidase based two-step immunostaining method. Counting was performed on two parallel sections at the ITF using an image analyser. The Ki-67 labelling index (LI) was determined by measuring the number of nuclei/mm(2) of epithelium. RESULTS: Our results show that the density of proliferating cells is related to clinical staging, with advanced stage of disease having a significantly higher Ki-67 LI compared with early stage of disease (2111 +/- 905 vs. 1908 +/- 913; P = 0.03). Importantly, this study shows that tumours that have metastasised have a significantly higher Ki-67 LI than tumours where distant metastasis was not detected (3257 +/- 650 vs. 1966 +/- 881; P < 0.0001). CONCLUSIONS: Cell proliferation, as measured by the Ki-67 LI at the ITF, has a positive relationship with clinical staging, tumour thickness, smoking status of the patient and alcohol consumption. Further, we suggest that a multicenter study with a large cohort of patients is indicated to fully elucidate whether cell proliferation at the ITF is directly related to patient survival. 相似文献
133.
134.
Background: Solitary pigmented lesions of melanocytic origin are uncommon in the oral mucosa. These lesions include the oral and labial melanotic macule, oral melanocytic nevus, oral melanoacanthoma, oral melanoma and atypical melanocytic proliferation. The purpose of the study was twofold: to report a large series of solitary melanocytic lesions from one source, and to determine the relative frequency of these lesions. Methods: The study was based on a systematic search of the files of the Pacific Oral and Maxillofacial Pathology Laboratory, University of the Pacific, San Francisco for solitary pigmented melanocytic lesions (benign and malignant) accessed during the years 1984–2002. Results: Of the 89 430 biopsies accessed during the 19‐year period, 773 (0.83%) cases of solitary pigmented melanocytic lesions in the oral mucosa were identified. Oral and labial melanotic macules were the most common melanocytic lesions comprising 86.1% of the entire group and 0.7% of the total number of accessed biopsies. The vermilion border and gingiva were the most common sites (31.1% and 31.0% respectively). Oral melanocytic nevi comprised 11.8% of the entire melanocytic group and 0.1% of the total number of biopsies. The most common site was the palate (44%). Intramucosal nevi were the most common (64%), followed by compound nevi (16.5%) and common blue nevi (16.5%). Junctional nevi were uncommon (3.0%). Oral melanoacanthoma comprised only 0.9% of the entire melanocytic group and 0.008% of the total number of biopsies. Oral melanoma and atypical melanocytic proliferation were the least common lesions each comprising 0.6% of the entire melanocytic group and 0.006% of the total number of biopsies. The most common site for oral melanoma was the palate (60%). Conclusion: The palate was the most common location for both melanocytic nevi and oral melanoma. Thus, all melanocytic lesions in the palate should be viewed with caution and biopsy is recommended to rule out melanoma. Further studies are required to elucidate the entity of oral atypical melanocytic proliferation. 相似文献
135.
R. C. Borra P. M. Andrade L. Corrêa M. D. Novelli 《European journal of dental education》2007,11(2):87-92
BACKGROUND: Making diagnoses in oral pathology are often difficult and confusing in dental practice, especially for the less-experienced dental student. One of the most promising areas in bioinformatics is computer-aided diagnosis, where a computer system is capable of imitating human reasoning ability and provides diagnoses with an accuracy approaching that of expert professionals. This type of system could be an alternative tool for assisting dental students to overcome the difficulties of the oral pathology learning process. This could allow students to define variables and information, important to improving the decision-making performance. However, no current open data management system has been integrated with an artificial intelligence system in a user-friendly environment. Such a system could also be used as an education tool to help students perform diagnoses. The aim of the present study was to develop and test an open case-based decision-support system. METHODS: An open decision-support system based on Bayes' theorem connected to a relational database was developed using the C++ programming language. The software was tested in the computerisation of a surgical pathology service and in simulating the diagnosis of 43 known cases of oral bone disease. The simulation was performed after the system was initially filled with data from 401 cases of oral bone disease. RESULTS: The system allowed the authors to construct and to manage a pathology database, and to simulate diagnoses using the variables from the database. CONCLUSION: Combining a relational database and an open decision-support system in the same user-friendly environment proved effective in simulating diagnoses based on information from an updated database. 相似文献
136.
JUDITH VAN ASPEREN OLAF H. VAN TELLINGEN JOS H. BEIJNEN 《Pharmacological research》1998,37(6):429-435
P-glycoprotein, a membrane-associated transport protein, has recently been recognised as an important element of the intestinal epithelium. This paper summarises thein vivodata on the pharmacological role of intestinal P-glycoprotein. These data show that P-glycoprotein contributes to the elimination of many drugs by mediating their direct secretion from the blood into the intestinal lumen. In addition, there is also evidence that this protein can limit oral drug absorption. Hence, inhibition of intestinal P-glycoprotein, e.g. by a reversal agent like cyclosporin A, may be a promising strategy for improving the oral bioavailability of P-glycoprotein substrate drugs. Indeed, several preclinical and clinical studies have shown that coadministration of drugs with a reversal agent can substantially increase oral drug absorption. 相似文献
137.
D M Reboussin D C Goff E W Lipkin D M Herrington J Summerson M Steffes R J Crouse L Jovanovic M N Feinglos J L Probstfield M A Banerji D J Pettitt J Williamson 《Diabetic medicine》2004,21(10):1082-1089
OBJECTIVE: To examine the effect of short-term improvements in glycaemic control on brachial artery endothelial function as a marker of cardiovascular health. METHODS: Persons with Type 2 diabetes who were poorly controlled on oral therapy were randomly assigned to monotherapy with repaglinide or combination therapy with repaglinide plus metformin. Brachial artery flow-mediated vasodilation was assessed by ultrasonography at randomization and following 16 weeks of therapy. The primary outcome was change in brachial artery endothelial function from baseline. Comparison of randomized groups was a secondary aim. RESULTS: Eighty-six participants were randomized, and 83 were followed to study completion. Post occlusion brachial artery vasodilation was 3.74% at baseline and 3.82% following 16 weeks of therapy (P = 0.77). The treatment effect was 0.08% (95% CI: -0.48%, 0.64%). No difference was seen between treatment groups (P = 0.69). Overall, A1C was reduced from 8.3% to 7.0%, with a greater reduction in the combination therapy group (from 8.4% to 6.7%) than in the monotherapy group (from 8.3% to 7.3%, p for difference between groups = 0.01). Statistically significant reductions were observed in fasting glucose, and plasminogen activator inhibitor-1. Statistically significant increases were observed for fasting insulin, uric acid, weight and BMI. CONCLUSIONS: Brachial artery endothelial function was not influenced by short-term improvements in glycaemic control. The CONTROL DM group was successful in lowering A1C. Future research should explore more intensive and longer-lasting improvements in glycaemic control on endothelial function. Some data previously published in abstract form (Diabetes 2001; 50 (Suppl. 2): A217). 相似文献
138.
公伟宏 《华北煤炭医学院学报》2003,5(2):137-138
目的:评价太极通天液治疗血管性痴呆的临床疗效。方法:随机将148例血管性痴呆分为太极通天液治疗组和丹参口服液对照组,另接应用韦氏成人智力量表评分,将血管性痴呆组分为3个亚组:即80-89分组,70-79分组和70分以下组,观察期为3个月。结果:太极通天液治疗前后WAIS-RC评分与对照组比较,80-89分组和70-79分组均有统计学差异(P<0.05),而70分以下组无统计学差异(P>0.05),结论:太极通天液对血管性痴呆有较好的治疗效果,且与痴呆病情程度有关。 相似文献
139.
P. Botas E. Delgado G. Castaño C. Díaz de Greñu J. Prieto F. J. Díaz-Cadórniga 《Diabetic medicine》2003,20(11):904-908
AIMS: To estimate the prevalence of diabetes mellitus with three diagnostic criteria (WHO-1985 and 1999 and ADA-1997), evaluate their concordance and analyse the sensitivity and specificity of the different screening strategies for diabetes. METHODS: A cross-sectional population study with two-step sampling. One thousand and 34 people were selected randomly. A 75-g oral glucose tolerance test (OGTT) was performed and venous blood samples were obtained fasting and at 2 h. RESULTS: The prevalence of known Type 2 diabetes mellitus (DM-2) is 4%[95% confidence interval (CI) 2.8, 5.1]. By WHO-1985 criteria the prevalence of unknown DM-2 is 5.9% (4.5, 7.4); by ADA-1997 criteria 3.5% (2.5, 4.6) and by WHO-1999 criteria 7.3% (5.8, 8.8). Diagnostic overlap and statistical concordance (coefficient K) are WHO-1985/ADA-1997 29.3%, K=0.42; WHO-1985/WHO-1999 80%, K=0.88; ADA-1997/WHO-1999 48%, K=0.63. If only fasting glucose was used (following ADA-1997), 36.3% of those with diabetes (2-h glucose > or =11.1 mmol/l) would be diagnosed. If OGTT was performed (i) in those with a fasting glucose between 6.1 mmol/l and 6.9 mmol/l (9.8% of the population) we would diagnose 66.6%, and (ii) in all those between 5.7 mmol/l and 6.9 mmol/l (18.9% of the population) 81.8% would be diagnosed. CONCLUSIONS: The ADA criteria decrease the prevalence of DM in the adult population of Asturias by 2.4% and concordance with the classical criteria (WHO-1985) was only 29.3%. Using fasting glucose only (ADA-1997) diagnoses 36.3% of those with diabetes. The recent recommendations of the WHO-1999 increases this to 66.6%. To improve the diagnostic strategy for diabetes and detect up to 81.8% of patients, we propose the use of OGTT for all those with a fasting glucose between 5.7 mmol/l and 6.9 mmol/l. 相似文献
140.
邢耀东 《中国医学教育技术》2006,20(1):25-27
文章从传播效果的角度详尽分析了多媒体教学和网络教学中的信息超载现象,并提出相应的解决对策。 相似文献