全文获取类型
收费全文 | 1655篇 |
免费 | 78篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 69篇 |
妇产科学 | 62篇 |
基础医学 | 138篇 |
口腔科学 | 242篇 |
临床医学 | 117篇 |
内科学 | 203篇 |
皮肤病学 | 14篇 |
神经病学 | 51篇 |
特种医学 | 28篇 |
外科学 | 224篇 |
综合类 | 193篇 |
预防医学 | 101篇 |
眼科学 | 4篇 |
药学 | 96篇 |
中国医学 | 40篇 |
肿瘤学 | 169篇 |
出版年
2023年 | 29篇 |
2022年 | 73篇 |
2021年 | 69篇 |
2020年 | 70篇 |
2019年 | 73篇 |
2018年 | 59篇 |
2017年 | 45篇 |
2016年 | 62篇 |
2015年 | 68篇 |
2014年 | 154篇 |
2013年 | 111篇 |
2012年 | 109篇 |
2011年 | 85篇 |
2010年 | 77篇 |
2009年 | 84篇 |
2008年 | 73篇 |
2007年 | 85篇 |
2006年 | 63篇 |
2005年 | 65篇 |
2004年 | 44篇 |
2003年 | 33篇 |
2002年 | 21篇 |
2001年 | 32篇 |
2000年 | 19篇 |
1999年 | 31篇 |
1998年 | 9篇 |
1997年 | 12篇 |
1996年 | 16篇 |
1995年 | 12篇 |
1994年 | 13篇 |
1993年 | 8篇 |
1992年 | 8篇 |
1991年 | 6篇 |
1990年 | 3篇 |
1989年 | 8篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 7篇 |
1983年 | 5篇 |
1982年 | 7篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有1769条查询结果,搜索用时 125 毫秒
61.
目的探讨药物洗脱支架(drug-eluting stents,DES)完全性血运重建与部分血运重建治疗冠心病多支病变的安全性和疗效。方法选取2011年1月至2012年11月在河南省胸科医院心内科接受PCI治疗的多支病变(multivessel diseases,MVD)患者205例,年龄35~84岁,男性112例,女性93例。根据血运重建情况分为完全性血运重建组106例;部分血运重建组99例。术后1年内定期于心内科门诊或电话随访患者。记录患者一般临床情况、纽约心脏病协会(NYHA)心功能分级、再次住院、主要不良事件(MACE)发生情况。结果与完全性血运重建组一般情况比较,部分血运重建组年龄、性别比例、合并症发生率、并发症发生率、心功能3级以及再次入院的人数无明显变化(P均0.05)。完全性血运重建组(5.6%)MACE事件发生率与部分血运重建组(8.8%)比较无统计学差异(P0.05)。结论功能性部分血运重建治疗冠心病多支病变的疗效不劣于完全性血运重建。 相似文献
62.
Seoung‐Jin Hong Hyeonjong Lee Janghyun Paek Ahran Pae Hyeong‐Seob Kim Kung‐Rock Kwon Kwantae Noh 《Journal of prosthodontics》2019,28(5):592-595
The conventional method for impressions of flabby tissue uses modified trays and highly flowable materials, but mucostatic impressions are difficult to achieve due to the viscous and the elastic natures of impression materials. In this report, a technique is presented in which conventional impression and intraoral scanning for a fully edentulous patient with flabby tissue are combined. The definitive impression was obtained by applying appropriate pressure to each tissue area, and the denture can be maintained passively and stable at rest and during function. 相似文献
63.
Jeremy D. Robertson Pauline Higgins Jamie Price Scott Dunkley Giulio Barrese Julie Curtin 《Thrombosis research》2014
Introduction
It has been postulated that factor VIII (FVIII) products containing von Willebrand factor (VWF) may improve immune tolerance induction (ITI) success rate in patients with haemophilia A and poor prognostic factors.Materials and methods
We conducted a retrospective cohort analysis of a FVIII/VWF concentrate (BIOSTATE®) for ITI in paediatric patients with severe haemophilia A (SHA) and inhibitors, from January 2003 to December 2011 at 3 paediatric-only Haemophilia Treatment Centres in Australia. Response to ITI was assessed at or before 33 months and at completion of ITI. Fifteen male patients with SHA were included in the analysis.Results
BIOSTATE was used for primary ITI in 8 patients (2 years, range 1.1–11.5 years) and for salvage ITI in 7 patients (9.9 years, range 1.1–15.4). At the end of the observation period there were 11 patients who achieved a complete response with BIOSTATE after a median duration of 21 months (range 5–85 months); a partial response was achieved in 2 patients in whom ITI is ongoing. Therefore, the overall response rate was 86.6%. Two patients were deemed treatment failures: one due to non-compliance after 18 months of ITI and another in whom a partial response had not been achieved after 22 months of ITI.Conclusion
BIOSTATE was well-tolerated and effective when used for primary or salvage ITI in this cohort of paediatric patients with SHA and a high-level inhibitor. 相似文献64.
Central venous catheter (CVC) placement is a common bedside procedure that is frequently performed in critically ill patients. More than 5 million CVCs are inserted annually across the United States alone. Procedure-related complications may vary from minor bleeding to life-threatening complications such as arterial perforation and pneumothorax. Cardiac arrhythmias can often occur during the guidewire placement, and bundle-branch blocks have also been reported. We herewith report a case of complete heart block during CVC placement, which is a rare but serious complication of this procedure. Because the patient had a preexisting left bundle-branch block, complete heart block likely resulted from a probable trauma to the right bundle branch during the guidewire insertion. 相似文献
65.
The determination of the occlusal vertical dimension and proper positioning of the anterior teeth are major factors in making complete dentures which will give optimum service. In this study, efforts were made to evaluate the reliability of measurement of vertical distance between the anterosuperior most point on the lingual frenum and mesioincisal edges of mandibular central incisors in natural dentition among different age groups and in complete denture wearers. Three hundred dentulous subjects belonging to different age groups and hundred edentulous patients wearing complete dentures were selected. The dentulous group was divided into three groups, group I (20–40 years), group II (41–60 years), group III (61 years and above) and the edentulous subjects being group IV ( 40–60 years). Mandibular irreversible hydrocolloid impression (Alginate) was made using modified stock tray. In edentulous subjects impression was made with denture in position. The vertical distance between anterosuperior most point on the lingual frenum and mesioincisal edges of mandibular central incisors was measured on the dentulous casts and casts of complete denture wearer using dental surveyor and the vernier calipers. The values were tabulated and statistically analysed. The mean vertical distance between anterosuperior most point on the lingual frenum and mesioincisal edges of mandibular central incisors among dentulous subjects was 12.3 mm and among complete denture wearers was found to be 13.2 mm. There was no significant variation in the mean vertical distance among dentulous subjects belonging to different age groups. At 5 % significance level, statistically there was a significant difference in the mean vertical distance between group I and group IV; group II and group IV. 相似文献
66.
Mridul Thakur Veena Jain Hari Parkash Pravesh Kumar 《Journal of Indian Prosthodontic Society》2012,12(3):175-181
To evaluate and compare the centric relation and horizontal condylar guidance using interocclusal wax and extra oral Gothic arch methods and subjective evaluation of dentures thus fabricated. Centric relation and horizontal condylar guidance was recorded by using interocclusal wax and gothic arch tracing in 28 completely edentulous patients. These records were transferred to the articulator and difference in both values was recorded. After that patients were divided in two groups according to the centric relation and horizontal condylar guidance recording method used to achieve balanced occlusion. Response of the dentures was subjectively evaluated using “Woelfel subjective evaluation criteria”. Centric relation recorded by both the methods did coincide in 7.14 % of patients. Centric relation recorded by interocclusal wax was posterior to Gothic centric relation in 21.43 % of patients, and anterior to Gothic centric relation in 71.42 % patients. Gothic arch tracings gave higher mean guidance values on both the sides as compared to protrusive wax record in all the subjects, although the difference was statistically insignificant (P > 0.05). Subjective evaluation showed statistical insignificance for all the parameters in both groups. Gothic arch method records the centric relation at a more posterior position than the Static method, but it does not make any difference in clinical performance of the complete denture. Horizontal condylar guidance angle was approximately similar by both the methods. 相似文献
67.
目的探讨种植磁附着体全口义齿对下颌牙槽嵴重度吸收的无牙颌患者的修复效果。方法采用C D I C牙种植体及配套磁性附着体,为15例下颌牙槽嵴重度吸收的无牙颌患者在下颌两侧第一前磨牙区各植入1枚种植体,4~6个月后制作下颌全口义齿并在组织面粘固磁体。进行咀嚼效率和患者满意度测定。结果种植磁附着体全口义齿在粘固磁体后及粘固后2周的固位力和咀嚼效率均较放置磁体前明显提高,且患者满意度提高。结论磁性固位种植体覆盖义齿用于牙槽骨严重吸收的无牙颌患者修复治疗的临床效果好。 相似文献
68.
目的:评价计算机辅助设计在单侧完全性唇腭裂患儿术前矫治中的应用价值。方法:对10例单侧完全性唇腭裂新生儿取模,通过三维激光扫描仪对模型进行扫描并实现三维重建,三维诊断设计软件模拟整个错位上颌骨各骨段的矫正过程,并输出用于矫治器加工的数字模型。快速激光成型技术恢复矫治过程的模型并制作一系列矫治器,临床应用于单侧完全性唇腭裂患儿的术前矫正治疗。结果:经过3~4个月的术前矫正,错位牙槽骨排列成较为规则的弧形;唇部裂隙宽度减小,鼻翼塌陷畸形得到改善,鼻小柱偏斜得到纠正。结论:计算机辅助设计的单侧完全性唇腭裂患儿术前矫治能实现精确、量化的矫治目标,同时减少复诊次数,是一种高效、简洁的术前矫治方法。 相似文献
69.
70.
目的:研究全口义齿排牙后牙不同倾斜角度对义齿稳定性的影响。方法:随机抽取临床模型,参照丸森贤二的分类法分别采用Monson型排牙法、anti-Monson型排牙法及flat型排牙法[5]进行后牙区排牙,以1cm厚的橡胶垫在患者口内做咀嚼测试并进行分析。结果:上颌义齿后牙的排牙角度始终是Monson型排牙法最稳定,flat型排牙法和anti-Monson型排牙法不稳定;下颌义齿后牙的排牙角度应根据牙槽嵴的形态选择不同的排牙法;结论:全口义齿后牙区排牙时,倾斜角度不同对义齿固位与稳定有重要影响。 相似文献