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62.
健脾化湿通络法治疗类风湿关节炎贫血的临床研究 总被引:1,自引:0,他引:1
目的观察健脾化湿通络法治疗类风湿关节炎(rheumatoidarthritis,RA)贫血患者的临床疗效并探讨其作用机制。方法40例类风湿关节炎贫血患者随机分为3组新风胶囊治疗组20例(口服新风胶囊)、雷公藤治疗组10例(口服雷公藤多苷片)和甲氨蝶呤治疗组10例(口服甲氨蝶呤片)。3组均连续服药3个月。观察各组患者的临床疗效。比较治疗前后各组患者全身和关节症状、贫血、血清铁、C反应蛋白、类风湿因子、免疫球蛋白、白细胞介素10、肿瘤坏死因子α及红细胞生成素(erythropoietin,EPO)的变化,以及不良反应。结果新风胶囊治疗组在治疗总有效率、改善类风湿关节炎贫血患者关节症状及部分实验室检查指标(血沉、类风湿因子、C反应蛋白、免疫球蛋白)方面,与甲氨蝶呤治疗组和雷公藤治疗组相似;但在改善类风湿关节炎贫血患者全身症状、血红细胞计数、血红蛋白含量以及上调白细胞介素10、下调肿瘤坏死因子α、升高血清铁及调节血清EPO水平方面均优于甲氨蝶呤治疗组和雷公藤治疗组。结论依据从“脾”论治原则研制的具有健脾化湿通络功效的中药新风胶囊,能明显改善类风湿关节炎贫血患者的全身及贫血症状、缓解患者的关节症状,其机制与调整细胞因子平衡、调节血清EPO的水平及升高血清铁含量相关。 相似文献
63.
64.
四神止泻胶囊的制备及其质量控制 总被引:1,自引:0,他引:1
目的:制备四神止泻胶囊,并建立质量控制方法。方法:采用薄层色谱法鉴别肉豆蔻、五味子和吴茱萸三味药材,高效液相色谱法测定成品中补骨脂素和异补骨脂素的含量。结果:肉豆蔻、五味子和吴茱萸薄层色谱斑点清晰;成品三批中补骨脂素和异补骨脂素含量稳定。结论:四神止泻胶囊制备工艺合理,质量控制方法可行。 相似文献
65.
目的:建立生化产复康胶囊中阿魏酸的含量测定方法。方法:采用高效液相色谱法,以kromasil C18柱为固定相,乙睛-0.085%磷酸溶液(17:83)为流动相,检测波长315nm,流速1.0ml/min,柱温35℃。结果:阿魏酸在0.076~0.228ug(r=0.9999)范围内线性关系良好,平均回收率为100.25%、RSD为1.84%。结论:本方法简便,准确,重现性好,可用于测定生化产复康胶囊中阿魏酸的含量。 相似文献
66.
We present a rare case of a non-calcified pilomatricoma in a 67-year-old man. This tumor was extremely large in size, and
its location, in the lower extremity, was very unusual. The clinical, radiographic, and histopathological features are described
in detail. The role of magnetic resonance imaging (MRI) in the diagnosis of this entity is discussed. Definite internal reticulations
and septations were observed. A possible explanation for this observation is that the high signal intensity reticulations
may represent edematous stroma surrounding basaloid cells.
Received: 8 July 1999 Revision requested: 28 July 1999 Revision received: 10 September 1999 Accepted: 13 September 1999 相似文献
67.
Alveolar soft part sarcoma: MR and angiographic findings 总被引:5,自引:5,他引:0
Suh JS Cho J Lee SH Shin KH Yang WI Lee JH Cho JH Suh KJ Lee YJ Ryu KN 《Skeletal radiology》2000,29(12):680-689
Objective. To present the MR and angiographic findings of alveolar soft part sarcoma (ASPS).
Design and patients. MR examinations (12 tumors of 10 patients) of ASPS performed at multiple hospitals were retrospectively reviewed. The tumors
were found in the thigh (n=4), lower leg (n=4), femur (n=2, local metastasis), scalp (n=1) and arm (n=1). The MR signal characteristics including signal intensity, homogeneity and signal void of lesions and bony invasion including
direct invasion or local metastasis were evaluated. Angiographic findings (n=4) and post-embolotherapy follow-up MR imaging (n=2) findings were also assessed.
Results. Local bony metastasis was found in two cases. Seven tumors showed heterogeneous high signal intensity on T1- and T2-weighted
images with good enhancement. One tumor had a very high signal on T1-weighted images. Eight tumors (67%) showed numerous signal
voids in or near the tumors. All four angiographic studies showed numerous enlarged vessels, arteriovenous shunts and delayed
washout. Two cases mimicked arteriovenous malformations on angiographic studies but MR images demonstrated solid soft tissue
components as well as tortuous vessels.
Conclusions. High signal on T1-weighted image and numerous signal voids are highly suggestive of ASPS, although they are not universal
as has been suggested and arteriovenous malformation should be included in the differential diagnosis. Local bony metastases
in ASPS were seen in two cases and should be carefully investigated.
Received: 12 April 2000 Revision requested: 27 June 2000, 8 August 2000 Revision received: 2 August 2000, 21 August 2000 Accepted:
22 August 2000 相似文献
68.
69.
70.
Muhammad Tahir Khan Sadaf Arooj Muhammad Umer Mukhtar Rewati Raman 《Radiology Case Reports》2022,17(10):3674
Maffucci syndrome is a non-hereditary congenital condition that affects the skin and skeleton. Enchondromas (benign cartilage enlargements), bone abnormalities, and venous anomalies (hemangiomas) are all symptoms. Enchondromas occur as a result of mesodermal dysplasia and have the potential to become cancerous. They are most commonly found on the phalanges and long bones. Venous abnormalities commonly manifest themselves as soft lumps or tumors on the distal extremities. A 19-year-old boy presented with swellings on his fingers and left foot since the age of 5, along with a few bluish soft tissue swellings on his left heel. Multiple expansile lytic lesions and soft tissue swellings with phleboliths were seen on X-ray. Histology confirmed the diagnosis of hemangiomas and enchondromas. Soft tissue swellings were found to have hyper echoic areas, as well as modest marginal blood flow on Doppler, which could indicate hemangiomas. Maffucci syndrome was identified, and treatment with a multidisciplinary approach was initiated. Maffucci syndrome is a rare genetic illness reported in the literature less than 200 times. The enchondromas and hemangiomas have a strong link to malignant changes, with chondrosarcomas accounting for 30% of the associated malignancies. On X-ray, enchondromas are easily identified as osteolytic lesions with cortex thinning and endosteal scalloping while color Doppler ultrasound detects the presence of hemangiomas. Phleboliths are easily identified as small calcifications on X-rays. Radiographic examinations should be considered in patients presenting with bone or soft tissue swellings for an early diagnosis of Maffucci syndrome. 相似文献