Focal cortical dysplasia with calcification: a case report

Case report Focal cortical dysplasia (FCD) with calcification is rare. We presented a 13-year-old epileptic patient with FCD and calcification in the left frontal lobe. At age 24, the FCD lesion and the surrounding epileptogenic cortex and underlying subcortex were removed after chronic subdural electrode recording. Histological examination showed that the calcified lesion was not independent of the FCD lesion but located in the subcortical area of the FCD lesion. A neoplastic nature was ruled out for the lesion. Discussion The pathophysiological mechanism involved in the coexistence of FCD and calcification is discussed.     

Snake fetuin: Isolation and structural analysis of new fetuin family proteins from the sera of venomous snakes

Novel proteins were isolated from the sera of Chinese Mamushi (Gloydius blomhoffi brevicaudus) and Habu (Trimeresurus flavoviridis). The primary structures of these proteins were determined by protein sequencing, and the nucleotide sequences were established by cDNA cloning from the liver mRNAs. They belonged to the fetuin family having a double-headed cystatin-like domain and a His-rich domain, akin to HSF, an antihemorrhagic factor isolated from Habu serum. They showed no antihemorrhagic activity and were designated HSF-like proteins (HLPs). Mamushi serum contained two different HLPs termed HLP-A and HLP-B. Both HLP-A and Habu HLP had a unique 17-residue deletion in their His-rich domains. HLP-B comprised two glycosylated polypeptide chains and inhibited the precipitation of calcium phosphate as potently as does bovine fetuin. HLP-B was hence identified as a snake fetuin. The phylogenetic analysis of the fetuin family of proteins showed that antihemorrhagins and HLPs have evolved from this snake fetuin.     

颅脑钙化灶的MR磁敏感成像

目的:探讨磁敏感成像技术(SWI)对显示颅内钙化灶的敏感性,并探讨钙化灶在SWI序列中的信号特点。方法:搜13例颅内钙化患者(共56处钙化灶)均进行CT和MRT1WI、T2WI和SWI扫描。结果:钙化灶在T1WI和T2WI上信号多样,没有特异性;在SWI相位校正图上显示为高信号或以高信号为主的混杂信号;在SWI重建图中显示为低信号。98.21%(55/56)的钙化灶DWI上均能显示,且病灶大小和形态与CT所见一致。颅内生理性和病理性钙化灶在SWI序列上检出率和信号特点的差异无统计学意义;脑实质内和脑室系统内钙化灶在SWI序列上检出率和信号特点的差异无统计意义。结论:SWI序列对颅内钙化灶的显示和检出敏感性高,可弥补常规MRI序列对钙化灶显示的不足。     

The occurrence of macroscopical pituitary calcifications in prolactinomas

Summary Radiographs of the sella turcica from 73 hyperprolactinaemic women, were followed-up for 5 to 13 years. Six women (8%) were found to harbour granular calcific deposits in the anterior part of the sella turcica visible on the plain radiographs. In three women the calcification increased in size during follow-up. This was accompanied by signs of regression of other features of pituitary tumour on the radiographs in two women. Pituitary calcifications associated with hyperprolactinaemia seem to represent a benign and regressive process.     

双膝外侧半月板钙化1例

患者女,60岁,两个月来无明显诱因左膝关节肿痛,活动后症状加重,休息后症状可有缓解,近两天疼痛症状明显加重并功能受限而入院治疗。查体:左膝关节肿胀,呈屈曲畸形,关节绞锁,活动受限,外侧关节间隙压痛明显。CR表现:左膝关节外侧间隙内见一平行于关节面,不均匀细条状高密度影,内端止于胫骨髁间棘,边缘清晰,无其他肌腱钙化;CT表现:左膝外侧半月板呈不连续环状、蛋壳状钙化,右膝外侧半月板呈细线状、浅弧状钙化(图1),未见其它肌腱韧带钙化,关节未见积液表现,影像学诊断:双膝外侧半月板钙化。手术病理诊断:半月板钙化。讨论半月板属纤维软骨,…     

2D超声对风湿性二尖瓣钙化诊断的价值

本文对100例风湿性二尖瓣钙化、纤维化进行了术前的超声检查和术后切除的瓣膜标本的大体和X线拍片检查,提出了二尖瓣钙化、纤维化程度的超声分类标准。三种方法表明二尖瓣钙化、纤维化的检出率分别为57～60％、40～43％。超声、X线拍片二种方法对照,钙化符合率Ⅱ、Ⅲ度为100％,点状、Ⅰ度为92.8％;纤维化符合率Ⅰ、Ⅱ度为100％。Ⅲ度为85％。钙化、纤维化分布均以交界为多见,其程度与瓣口狭窄有一定的关系。本文进一步证明了超声诊断二类瓣钙化、纤维化的敏感性和准确性,并可作为临床选择手术的依据之一。     

64-SCTCA与CCA对钙化及非钙化性冠状动脉狭窄程度评估的一致性分析

目的64层螺旋CT冠状动脉血管成像（64-SCTCA）对钙化及非钙化冠状动脉狭窄程度的评估与选择性X线冠状动脉成像（CCA）比较,两者进行一致性分析。方法搜集67例患者64-SCTCA及近期CCA资料,根据冠状动脉钙化积分的扫描结果将冠状动脉分为非钙化组和钙化组,按管径无狭窄,轻度狭窄（≤50%）,中度狭窄（51%～75%）,重度狭窄或闭塞（76%～100%）4个等级分别比较两组的64-SCTCA与CCA评估狭窄程度的一致性。统计学分析采用Kappa评价方法。结果67例患者共评价分析冠状动脉804段血管,其中非钙化组冠状动脉714段,钙化组冠状动脉90段;在非钙化组64SCTCA和CCA一致性分析显示Kappa值=0.643,二者对冠状动脉狭窄程度评估一致性好;在钙化组64-SCTCA和CCA一致性分析显示Kappa值=0.145,二者对冠状动脉狭窄程度评估一致性差,有55（55/90）段钙化冠状动脉血管64-SCTCA评估狭窄程度高于CCA。结论64-SCTCA对非钙化冠状动脉有无狭窄及狭窄程度显示准确性高,对管壁斑块显示好;对有钙化斑块的冠状动脉狭窄评估与CCA的一致性差,64-SCTCA常常会高估狭窄程度。     

影响器械进入上颌磨牙近颊根第二根管的因素

目的:分析影响器械进入上颌磨牙近颊根第二根管的因素和评价根管显微镜定位离体上颌磨牙近颊根第二根管的能力。方法:①收集离体上颌第一、二磨牙共550颗;②在常规和根管显微镜辅助下分别探查近颊根管,记录近颊根第二根管检出率和影响器械进入该根管的因素。结果:①常规和根管显微镜条件下近颊根第二根管检出率在上颌第一磨牙分别为51.8%(112/216)和78.2%(169/216);第二磨牙分别为23.7%(79/334)和41.3%(138/334)。使用根管显微镜可明显提高近颊根第二根管的检出率,P<0.01;②影响器械进入近颊根第二根管的主要因素有近中壁牙本质悬突、牙本质碎屑和髓腔弥漫性钙化物或髓石等。结论:根管显微镜辅助下可有效去除阻碍器械进入近颊根第二根管的因素,提高其检出率。     

抗坏血酸加透明质酸对软骨钙化化骨的影响

本实验观察到抗坏血酸（ＶＣ）加透骨质酸（ＨＡ）对胚鸡肢体骨的生长、发育有促进作用．能提高碱性磷酸酶活性（ＡＪＰ），使骨钙含量、骨长度、骨重量均增加。ＨＡ能协助ＶＣ促进钙化化骨．本实验用维生素Ｄ３（ＶＤ３）作阳性对照。     

北京社区自然抽样人群冠状动脉钙化的多排螺旋CT初步研究

目的 探讨住院2型糖尿病(T2DM)患者血压控制的影响因素。方法 169例合并高血压的T2DM患者给予降压等综合治疗,以出院时血压130/80mmHg为界限分为达标组(n=97)及未达标组(n=72),比较两组入院时临床及实验室指标,并通过回归分析观察各种因素对出院时平均动脉压(MAP)水平的影响。结果 全组T2DM入院时收缩压(SBP)为143±15 mmHg,舒张压(DBP)为 78±8 mmHg,控制达标率仅17.8%;出院时血压达标率57.4%,降压药物种类平均增加0.8种。未达标组患者入院时SBP(151±15 vs. 137±12 mmHg, P=0.000)、DBP(80±9 vs. 77±7 mmHg, P=0.000)均高于达标组,且总胆固醇(TC)及24h尿白蛋白排泄率(UAE)显著升高。回归分析显示MAP与入院时SBP、DBP、TC及高血压病程显著正相关,与年龄负相关;MAP与UAE显著正相关(r=0.303, P=0.000)。合并糖尿病肾病(DN)患者随UAE增多而SBP显著升高,大量蛋白尿者需要多种降压药物联合且血压难以控制。结论 T2DM患者门诊血压控制达标率低;住院T2DM患者血压控制受入院时血压水平、高血压病程、高胆固醇血症、高UAE等因素影响;UAE增加可能是合并DN患者血压难以控制的直接原因。