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121.
Kenneth Siu-Sing Leung Timothy Ting-Leung Ng Alan Ka-Lun Wu Miranda Chong-Yee Yau Hiu-Yin Lao Ming-Pan Choi Kingsley King-Gee Tam Lam-Kwong Lee Barry Kin-Chung Wong Alex Yat Man Ho Kam-Tong Yip Kwok-Cheung Lung Raymond Wai-To Liu Eugene Yuk-Keung Tso Wai-Shing Leung Man-Chun Chan Yuk-Yung Ng Kit-Man Sin Kitty Sau-Chun Fung Sandy Ka-Yee Chau Wing-Kin To Tak-Lun Que David Ho-Keung Shum Shea Ping Yip Wing Cheong Yam Gilman Kit-Hang Siu 《Emerging infectious diseases》2021,27(1):196
Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10−3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread. 相似文献
122.
Pyoeng Gyun Choe Chang Kyung Kang Hyeon Jeong Suh Jongtak Jung Kyoung-Ho Song Ji Hwan Bang Eu Suk Kim Hong Bin Kim Sang Won Park Nam Joong Kim Wan Beom Park Myoung-don Oh 《Emerging infectious diseases》2021,27(1):327
We investigated the kinetics of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in 7 asymptomatic persons and 11 patients with pneumonia. The geometric mean titer of neutralizing antibodies declined from 219.4 at 2 months to 143.7 at 5 months after infection, indicating a waning antibody response. 相似文献
123.
Andrea Calcagno Valeria Ghisetti Teresa Emanuele Mattia Trunfio Silvia Faraoni Lucio Boglione Elisa Burdino Sabrina Audagnotto Filippo Lipani Marco Nigra Antonio DAvolio Stefano Bonora Giovanni Di Perri 《Emerging infectious diseases》2021,27(1):303
We measured severe acute respiratory syndrome coronavirus 2 spike protein subunits S1/S2 antibodies by using capillary electrophoresis and a chemiluminescence immunoassay for 5,444 active healthcare workers in Italy. Seroprevalence was 6.9% and higher among participants having contact with patients. Seroconversion was not observed in 37/213 previously infected participants. 相似文献
124.
Fabian Heinrich Kira Meißner Felicia Langenwalder Klaus Püschel Dominik Nrz Armin Hoffmann Marc Lütgehetmann Martin Aepfelbacher Eric Bibiza-Freiwald Susanne Pfefferle Axel Heinemann 《Emerging infectious diseases》2021,27(1):329
Analyses of infection chains have demonstrated that severe acute respiratory syndrome coronavirus 2 is highly transmissive. However, data on postmortem stability and infectivity are lacking. Our finding of nasopharyngeal viral RNA stability in 79 corpses showed no time-dependent decrease. Maintained infectivity is supported by virus isolation up to 35 hours postmortem. 相似文献
125.
Catherine A. Hogan ChunHong Huang Malaya K. Sahoo Hannah Wang Becky Jiang Mamdouh Sibai Marisa Holubar Roshni Mathew James Zehnder Benjamin A. Pinsky 《Emerging infectious diseases》2021,27(2):632
We developed an assay that detects minus-strand RNA as a surrogate for actively replicating severe acute respiratory syndrome coronavirus 2. We detected minus-strand RNA in 41 persons with coronavirus disease up to 30 days after symptom onset. This assay might inform clinical decision-making about patient infectiousness. 相似文献
126.
Mohammad M. Obaidat James C. Graziano Maria Morales-Betoulle Shelley M. Brown Cheng-Feng Chiang John D. Klena 《Emerging infectious diseases》2021,27(2):653
The epidemiology of Rift Valley fever virus (RVFV) and Crimean-Congo hemorrhagic fever virus (CCHFV) in Jordan is unknown. Our investigation showed 3% of 989 tested dairy cattle, sheep, and goats were RVFV seropositive and 14% were CCHFV seropositive. Ongoing surveillance is needed to assess risk to humans and protect public health. 相似文献
127.
Brittany L. Rosen Pamina Gorbach Lili Ding Courtney Covert Aaron C. Ermel Emmanuel Chandler Talía Malagón Jessica A. Kahn 《The Journal of adolescent health》2021,68(4):696-704
PurposeThis study aimed to determine individual- and partner-level factors associated with human papillomavirus (HPV) infection in vaccinated and unvaccinated men.MethodsA total of 747 men, aged 13–26 years, completed a survey of sexual behaviors and were tested for genital and perianal/anal HPV (36 types). Sexual network variables included recent and lifetime concurrency (being in more than one sexual relationship at the same time) and recent sex partner discordance (by race, ethnicity, age, and number of sexual partners). We determined individual-level and sexual network variables associated with ≥1 HPV type and HPV16/18, stratified by vaccination status, using separate multivariable logistic regression models.ResultsParticipants' mean age was 21.2 years; 64% were positive for ≥1 HPV type and 21% for HPV16/18. Factors associated with ≥1 HPV type in unvaccinated men included recruitment site and lifetime concurrency. Factors associated with ≥1 HPV type among vaccinated men included recruitment site, Chlamydia history, main male partner, number of lifetime female partners, and no condom use with female partner. Factors associated with HPV16/18 in unvaccinated men included race and partner concurrency. Factors associated with HPV16/18 in vaccinated men included ethnicity, main male partner, and recent concurrency.ConclusionsSexual network variables associated with HPV infection were different based on vaccination status and HPV type, suggesting risk factors for HPV infection may change as the proportion of vaccinated men increases. In addition, participant report of concurrency and not knowing whether one had practiced concurrency were consistent risk factors; clinicians should consider including concurrency in the sexual history to determine the risk of HPV. 相似文献
128.
Jennifer L. Reed Evaline A. Alessandrini Judith Dexheimer Andrea Kachelmeyer Maurizio Macaluso Nanhua Zhang Jessica A. Kahn 《The Journal of adolescent health》2021,68(1):57-64
PurposeAdolescents represent more than half of the newly diagnosed sexually transmitted infections in the U.S. annually. Emergency departments (EDs) may serve as an effective, nontraditional setting to screen for chlamydia/gonorrhea (CT/GC). The objective was to evaluate the effectiveness of a universally offered CT/GC screening program in two pediatric ED settings.MethodsThis was a prospective, delayed start pragmatic study conducted over 18 months in two EDs within the same academic institution among ED adolescents aged 14–21 years with any chief complaint. Using a tablet device, adolescents were confidentially informed of CT/GC screening recommendations and were offered screening. If patients agreed to CT/GC testing, a clinical decision support tool was triggered to inform the provider and order testing. The main and key secondary outcomes were the proportion of CT/GC testing and positive CT/GC test results in each respective ED.ResultsBoth EDs experienced modest but statistically significant increases in CT/GC testing post- versus pre-intervention (main: 11.5% vs. 7.9%; confidence interval [CI]: 2.9–4.2; p < .0001 and satellite: 3.8% vs. 2.6%; 95% CI: .7–1.7; p < .0001). Among those tested, the positivity rate at the main ED did not significantly change post- versus pre-intervention (24.1% vs. 23.2%; 95% CI: ?1.9 to 3.8; p = .71) but significantly decreased at the satellite ED (7.6% vs. 14.8%; 95% CI: ?12.2 to ?2.2; p = .01).ConclusionsA universally offered screening intervention increased the proportion of adolescents who were tested at both EDs and the detection rates for CT/GC at the main ED, but patient acceptance of screening was low. 相似文献
129.
Federica Gigliucci Angela H.A.M. van Hoek Paola Chiani Arnold Knijn Fabio Minelli Gaia Scavia Eelco Franz Stefano Morabito Valeria Michelacci 《Emerging infectious diseases》2021,27(3):853
Shiga toxin–producing Escherichia coli (STEC) O80:H2 has emerged in Europe as a cause of hemolytic uremic syndrome associated with bacteremia. STEC O80:H2 harbors the mosaic plasmid pR444_A, which combines several virulence genes, including hlyF and antimicrobial resistance genes. pR444_A is found in some extraintestinal pathogenic E. coli (ExPEC) strains. We identified and characterized 53 STEC strains with ExPEC-associated virulence genes isolated in Italy and the Netherlands during 2000–2019. The isolates belong to 2 major populations: 1 belongs to sequence type 301 and harbors diverse stx2 subtypes, the intimin variant eae-ξ, and pO157-like and pR444_A plasmids; 1 consists of strains belonging to various sequence types, some of which lack the pO157 plasmid, the locus of enterocyte effacement, and the antimicrobial resistance–encoding region. Our results showed that STEC strains harboring ExPEC-associated virulence genes can include multiple serotypes and that the pR444_A plasmid can be acquired and mobilized by STEC strains. 相似文献
130.
Lorenz Ulrich Anna Michelitsch Nico Halwe Kerstin Wernike Donata Hoffmann Martin Beer 《Emerging infectious diseases》2021,27(4):1193
After experimental inoculation, severe acute respiratory syndrome coronavirus 2 infection was confirmed in bank voles by seroconversion within 8 days and detection of viral RNA in nasal tissue for up to 21 days. However, transmission to contact animals was not detected. Thus, bank voles are unlikely to establish effective transmission cycles in nature. 相似文献