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81.
The purpose of this study was to evaluate the cellular composition of the bone marrow of cynomolgus monkeys (Macaca fascicularis). Femoral bone marrow smears from 23 healthy, adult animals (11 males and 12 females) were examined. For each animal, three femoral bone marrow smears were prepared immediately after euthanasia and stained with May-Grünwald-Giemsa. On two of the three smears available, and for each of these smears, a 500-cell differential count was performed and the myeloid: erythroid (M:E) ratio established. The M:E ratio for males varied from 0.67∶1.00 to 1.85∶1.00 with a mean of 1.03∶1.00 and for females from 0.67∶1.00 to 1.63∶1.00 with a mean of 1.02∶1.00. The mean percentage of granulocytic, lymphocytic, plasmacytic and erythroid series was 47.60, 5.44, 1.45 and 46.05% for males and 47.28, 5.12, 1.49 and 46.28% for females. No significant differences were noted between males and females. All cell lines were well represented and showed normal maturation in both sexes. Megakaryocytes were adequate in number and morphology in all animals. Cynomolgus monkeys showed a bone marrow composition similar to rhesus monkeys (Macaca mulatta). Cytological examination of bone marrow was found to be a simple and rapid procedure, well suited to the toxicological research environment. It provided excellent information on cell distribution, morphology and maturation of the haematopoietic system.  相似文献   
82.
An 18-year-old woman with abdominal pain was diagnosed as having splenic cysts by computed tomography scan. She had high serum levels of CA19-9 (2886.8 U/mL; normal value, <35 U/mL), CA125 (131.1 U/mL; normal value, <35 U/mL) and soluble IL-2 receptor (1490 U/mL; normal range, 220-530 U/mL). The resected spleen weighed 1050 g, was 14 x 28 cm, and had more than 10 macroscopic cysts up to 10.3 x 9.5 cm. There were numerous microscopic cysts in the spleen and several on the splenic capsule. The levels of CA19-9 and CA125 in the cyst fluid were 2165550 U/mL and 160400 U/mL, respectively. After the surgery, the serum levels of the tumor markers decreased gradually. The inside of the largest cyst was mainly covered by granulation tissue with a focal lining of epithelial cells, and the other macroscopic cysts had stratified squamous epithelium. The microscopic splenic cysts and cysts on the splenic capsule were lined by either attenuated single-layered or multilayered epithelial cells. The lining epithelial cells of these cysts were positive for epithelial membrane antigen and cytokeratins. CA19-9 and CA125 were detected in the lining cells of the splenic cysts. In the present case, it is suspected that the splenic cysts were derived from the capsular lining cells that showed migration from the capsule or formed microcysts on the splenic capsule, as in the case of ovarian inclusion cysts.  相似文献   
83.
Developmental relationship between hematopoietic and endothelial cells   总被引:5,自引:0,他引:5  
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84.
It is well known that non Hodgkin's lymphoma (NHL) cells express various antigens which are normally involved in a variety of functions. In addition, NHL is diverse in its proliferative capacity. To investigate the relation between these factors and the clinical picture, 45 cases of NHL were studied by immunohistochemistry using snap-frozen materials obtained before therapy. Reactivities with 27 monoclonal antibodies were examined and the results were correlated with clinical findings. The expression of surface μ and CAM-1 in B-NHLs and CD25 in T-NHLs were significantly associated with bone marrow involvement. B-NHLs without expression of CD21(B2) and T-NHLs with CD25 were seen more frequently in cases with a LDH value of over 500 units/ml. The positivity rate of Ki-67 on B-NHLs was correlated with serum LDH value, NHL histologic classification, and overall survival. These data indicate that immunophenotyping and determination of the proliferative capacity of NHL are of value not only for confirmation of the histopathologic classification of the tumor but also for assessment of clinical behavior.  相似文献   
85.
Summary Haemangiosarcoma of bone is a very rare primary tumour with a variable history and differing radiographic and histological appearances. In some cases the lesion has similar features to the so-called adamantinoma of long bones in which the histogenesis is also unknown.Such a lesion is described which ocurred in the shaft of the right humerus of a 31-year-old man. Radiographically a centrally located area of osteolysis was seen without marginal sclerosis, but with erosion of the bony cortex. A biopsy was performed 16 months after the first radiographic examination and showed malignant tumour tissue which was difficult to classify histomorphologically. Several different neoplasms such as Ewing's sarcoma, myeloma, liposarcoma, malignant fibrous histiocytoma or a bone metastasis were suggested. Finally, a haemangiosarcoma or so-called adamantinoma of long bones was considered. The tumour was completely removed by en-bloc resection.Careful histomorphological investigation of the tumour tissue by means of light microscopy, cytology and electronmicroscopy showed a vascular pattern characteristic of a haemangiosarcoma. Using cytophotometric DNA measurements of the tumour cells, the lesion could be classified as being of lowgrade malignancy. This is confirmed since there has now been a 4-year follow up with no local recurrence or metastasis.There are many similarities between a well-differentiated haemangiosarcoma and an adamantinoma of long bones. The differential diagnosis and the histogenesis of the latter lesion is discussed. It is emphasized that the so-called adamantinoma of a long bone probably has a vascular origin.
Résumé L'hémangiosarcome est une tumeur osseuse primaire très rare, dont l'evolution est variable et dont les aspects radiologiques et histologiques sont divers. Dans quelques cas, la lésion ressemble à ce que l'on appelle «adamantinome des os longs», dont l'histogénèse est également inconnue.On présente ici un cas d'une telle tumeur, siégeant au niveau de la diaphyse humérale droite, chez un homme de 31 ans. Radiologiquement, il existait une zone centrale d'ostéolyse sans sclérose marginale mais avec érosion de la corticale. Une biopsie effectuée 16 mois après le premier examen radiologique a montré un tissu tumoral malin, difficile à classer histomorphologiquement.Plusieurs diagnostic ont été envisagée: sarcome d'Ewing, myélome, liposarcome, histiocystome fibreux malin, ou métastase osseuse. Finalement on a retenu le diagnostic soit d'hémangiosarcome, soit d'adamantinome. La tumeur a été complètement enlevée par résection en bloc.Des investigations histomorphologiques poussées du tissu tumoral par microscopie optique, cytologie et microscopie électronique ont mis en évidence les aspects vasculaires caractéristiques d'un hémangiosarcome. En utilisant les mesures cyto-photométriques d'ADN des cellules tumorales, la lésion a pu être classée comme ayant un degré de malignité peu élevé. Ceci a été confirmé par l'évolution, puisqu'avec 4 ans de recul il n'y a ni récidive locale ni métastase.Il y a beaucoup de similitudes entre un hémangiosarcome bien différencié et un adamantinome des os longs. Le diagnostic différentiel et l'histogénèse de cette dernière lésion sont discutes. L'origine vasculaire probable de l'adamentinome est soulignée.
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86.
Bone scan in the patellofemoral pain syndrome   总被引:3,自引:0,他引:3  
Summary Eighty patients who complained of retropatellar pain underwent evaluation by bone scintigraphy, intraosseous pressure determination, radiography, arthroscopy and physical diagnostic tests. The bone scans showed that 48% of the painful knees had an increased uptake compared with 9% for the normal joints. A highly significant correlation was evident between an increased uptake and established chondromalacia. For the diagnosis of a high pressure patella, radiography was only 7% sensitive (6/88), compared with 44% (39/88) for bone scintigraphy and 78% for the clinical sustained flexion test. The positive predictive value of a bone scan for detecting a high pressure patella was 0.72 (39/54). The best predictor was a positive sustained flexion test with a predictive value of 0.85 (69/81).
Résumé Dix-huit malades se plaignant de douleurs rétro-patellaires ont été examinés par scintigraphie, mesure de la pression intra-osseuse, radiographie, arthroscopie et tests cliniques. La scintigraphie a montré que 48% des genoux douloureux présentaient une hyperfixation contre 9% des articulations normales. Il existait une corrélation évidente, hautement significative, entre l'hyperfixation et la chondropathie rotulienne. Pour le diagnostic d'hyperpression intrapatellaire, la radiographie n'était démonstrative que dans 7% des cas (6/88) alors que la scintigraphie l'était dans 44% (30/88) et le test clinique de «flexion prolongée» dans 78%. La valeur d'une scintigraphie positive en faveur du diagnostic d'hyperpression intra-patellaire est de 0.72 (39/54). L'élément le plus fiable est la positivité du test de flexion prolongée qui a une valeur prédictive de 0.85 (69/81).
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87.
In a review of cases of fibrous cartilaginous dysplasia of bone, five of fibrocartilaginous lesions were found to be different in clinical behavior and radiographic and morphologic features from the others. We have named these previously undescribed tumors fibrocartilaginous mesenchymomas with low-grade malignancy in the fibrous elements.Dr. Bertoni is a visiting surgical pathologist from the Servizio di Anatomia ed Istologia Patologica, Bologna, Italy  相似文献   
88.
89.
维生素D缺乏性晚发性佝偻病的骨密度研究   总被引:1,自引:0,他引:1  
目的:探讨维生素D缺乏性晚发性佝偻病的骨密度变化;方法:采用病例对照研究方法。对640名学生进行问诊及体验,测定非优势侧尺挠骨中1/3交界处骨密度(BMD),病例组检测骨碱性磷酸酶,拍摄腕部X光片,病例组与对照组同测血250HD3;结果:病例组骨密度显著低于对照组,病例组250HD3异常者显著低于对照组;结论:晚佝病是由于维生素D缺乏所至的骨量减少性疾病,日后影响峰值骨量的形成,并与成人期骨质疏松有密切的关系,骨密度检查对晚佝病有重要诊断价值。  相似文献   
90.
目的:通过超声的引导,对肾囊肿采取精确定位穿刺治疗,从而使肾囊肿的治疗更为简便有效。方法:从1995年以来的肾囊肿患者中选取12例单纯性肾囊肿患者,在穿刺探头引导下,对肾囊肿进行穿刺注射无水乙醇治疗,并在术后3-12个月进行随访。结果:治疗后3个月治愈率41.7%,6个月66.7%,12个月治愈率83.3%,有效率100%,无并发症发生,结论:超声引导穿刺治疗肾囊肿方法简便,安全可靠,痛苦小,治愈率高,值得向广大基层医院推广。  相似文献   
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