复方丹参滴丸联合双环醇治疗酒精性肝病临床效果观察

目的：探讨复方丹参滴丸联合双环醇治疗酒精性肝病的临床效果。方法将70例酒精性肝病患者随机分为2组,对照组35例,给予双环醇治疗;观察组35例,给予双环醇加复方丹参滴丸口服,2组均连续用药16周。观察2组治疗前后肝功能指标及肝纤维化指标。结果2组治疗后丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、γ-谷氨酰转肽酶（GGT）、碱性磷酸酶（ALP）差异无明显统计学意义（P＆gt;0.05）;治疗组总胆红素及肝纤维化指标下降幅度明显优于对照组,差异有统计学意义（P＆lt;0.05）。2组治疗期间均未见明显不良反应。结论复方丹参滴丸联合双环醇治疗酒精性肝病效果更好,不良反应少,值得临床推广。     

双环醇对实验性非酒精性脂肪肝大鼠的防治作用

目的探讨双环醇对非酒精性脂肪肝大鼠的防治作用。方法采用高脂饲料饲养制备非酒精性脂肪肝大鼠模型,同时给予不同剂量双环醇治疗,通过检测血清肝酶谱丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、转肽酶（GGT）,血脂,肝组织匀浆三酰甘油含量和肝脏组织学变化,观察不同剂量双环醇对非酒精性脂肪肝大鼠的防治作用。结果模型组大鼠肝脏出现明显的脂肪变性,肝酶活性（AST、ALP、GGT）,血脂和肝组织三酰甘油含量升高;双环醇各剂量组肝细胞脂肪变显著减轻,肝酶活性（AST、ALP、GGT）、血脂和肝组织三酰甘油含量较模型组显著下降。结论双环醇对非酒精性脂肪肝具有良好的防治作用。     

双环醇治疗甲亢及抗甲状腺药物治疗后致肝功能损害疗效观察

目的了解双环醇片治疗甲亢所致肝功能损害及甲巯咪唑治疗后所致肝功能损害的疗效和安全性,为临床医师提供理论依据和用药方法。方法采用随机、对照、开放性临床研究,对95例甲亢患者随机分为试验组和对照组,分别用双环醇片和硫普罗宁片治疗,两组疗程均为12周。观察治疗前、后2周、4周、8周、12周ALT、AST、肾功、尿常规,同时观察一般状况及相关症状、体征。结果治疗组ALT、AST水平较对照组降低更为显著,且治疗12周疗效优于4周和8周;治疗组用药过程中均未出现不良反应。结论双环醇片对甲亢所致肝功能损害及甲巯咪唑治疗后所致肝功能损害患者有良好的疗效和安全性。     

Protective effect of bicyclol on lipopolysaccharide-induced acute lung injury in mice

Bicyclol is synthesized based on schisandrin, which is one of the main active components of Chinese herb Fructus Schisandrae. The purpose of this study is to investigate whether bicyclol has a beneficial effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Bicyclol was given to mice by gavage for three times. ALI was induced by vena caudalis injection of LPS. The last dose of bicyclol was administrated 1 h before LPS given. Mice in each group were sacrificed at different time point after LPS administration. As revealed by survival study, pretreatment with high doses of bicyclol reduced the mortality of mice from ALI. Bicyclol pretreatment significantly improved LPS-induced lung pathological changes, inhibited myeloperoxidase (MPO) activity, and reduced lung/body and lung wet/dry weight ratios. Bicyclol also inhibited the release of TNF-α, IL-1β and HMGB1, whereas simultaneously increased the expression of IL-10. Furthermore, the phosphorylation level of NF-κB p65 was markedly decreased by bicyclol. Taken together, our study showed that bicyclol improves survival rate and attenuates LPS-induced ALI. The protective mechanism may be due to the inhibition of NF-κB activation and regulation of cytokine secretion.     

双环醇对脂肪性肝病保护作用的研究进展

脂肪性肝病是多种原因引起的病变主体在肝小叶、以肝细胞脂肪变性和脂肪蓄积过多为主的临床病理综合征。临床上分为酒精性肝病（ALD）和非酒精性脂肪性肝病（NAFLD）两大类。双环醇是抗肝炎新药,具有抗氧化和抗炎的特性。本文就双环醇在脂肪性肝病的基础研究与临床应用的进展加以综述。     

Effects of Bicyclol on Liver Regeneration After Partial Hepatectomy in Rats

Bicyclol is a synthetic antihepatitis drug with antioxidative property. The present study was performed to investigate the effect of bicyclol on liver regeneration after partial hepatectomy in rats. Bicyclol (300 mg/kg) was given to rats subjected to 70% hepatectomy three times before operation. At 6, 24, and 48 h after resection, samples were collected for the measurement of serum alanine aminotransferase (ALT), total bilirubin (TBil), hepatic glycogen, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH). Moreover, liver regeneration rate, proliferating cell nuclear antigen (PCNA) labeling, proliferation index, and histopathological examination were evaluated at 48 h after hepatectomy. As a result, bicyclol significantly increased regeneration rate, mitotic index (MI), PCNA labeling index, and proliferation index in PH rats. Additionally, bicyclol remarkably inhibited the elevation of serum ALT and TBil levels, alleviated the formation of liver MDA, restored impaired antioxidant SOD and GSH, increased hepatic glycogen content, and also attenuated hepatic vacuolar degeneration. These results suggested that bicyclol had a beneficial effect on liver regenerative capacity of the remnant liver tissue after hepatectomy, probably due to its antioxidative property.     

双环醇联合多烯磷脂酰胆碱治疗甲亢性肝损伤的疗效观察

目的研究双环醇联合多烯磷脂酰胆碱治疗甲状腺功能亢进症(甲亢)性肝损伤的疗效。方法87例甲亢性肝损伤患者,依据治疗方式不同分为联合组(45例)与单一组(42例)。联合组患者采取双环醇联合多烯磷脂酰胆碱方案治疗,单一组患者采取单独使用多烯磷脂酰胆碱方案治疗。比较两组血清指标[超氧化物歧化酶(SOD)、甲状腺球蛋白抗体(TGA)、甲状腺微粒体抗体(TMA)、血清甲状腺球蛋白(HTG)、总胆红素(TBIL)、谷氨酸转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)]水平及治疗效果。结果治疗后,联合组的SOD为(246.93±90.03)ng/ml,高于单一组的(209.04±76.16)ng/ml,TGA、TMA、HTG分别为(19.56±11.03)%、(20.01±13.88)%、(8.25±7.09)ng/ml,均低于单一组的(24.21±9.16)%、(26.35±14.03)%、(14.95±8.74)ng/ml,差异均有统计学意义(P<0.05)。治疗后,联合组的ALT、AST、GGT、TBIL分别为(48.6±11.5)U/L、(52.4±8.8)U/L、(61.3±16.2)U/L、(22.4±9.8)mmol/L,均低于单一组的(55.8±11.3)U/L、(56.9±9.8)U/L、(78.2±11.5)U/L、(30.4±12.5)mmol/L,差异均有统计学意义(P<0.05)。联合组的治疗总有效率为91.11%,高于单一组的61.90%,差异有统计学意义(P<0.05)。结论采用双环醇联合多烯磷脂酰胆碱治疗方案,可有效调节甲亢性肝损伤患者的肝功能及血脂水平,提升临床疗效。     

双环醇治疗慢性乙型病毒性肝炎50例疗效观察

目的观察双环醇治疗慢性乙型病毒性肝炎的临床效果及不良反应.方法 100例慢性乙型病毒性肝炎患者分为2组,治疗组50例,口服双环醇片25 mg,每日3次;对照组50例,口服健肝灵胶囊3粒,每日3次,疗程均为24周,观察两组治疗前后肝功能指标（ALT、AST）及病毒标志物情况（HBV-DNA、HBeAg）和停药后反跳的发生情况.结果两组在治疗12周及24周时,ALT及AST均较治疗前下降,治疗12周时双环醇治疗组ALT及AST下降幅度较健肝灵治疗组好,差异有统计学意义（P＜0.05）;停药12周后双环醇治疗组未见明显AL及AST反跳,而健肝灵治疗组在停药12周后ALT及AST均有所升高,差异有统计学意义（P＜0.05）.结论双环醇片与健肝灵一样,具有较好的保肝、显著降低血清转氨酶、改善肝功能的疗效,双环醇对ALT、AST的早期下降作用优于健肝灵,可以在临床推广使用.     

双环醇片联合肌苷片治疗老年脂肪肝的疗效观察

目的探讨双环醇片联合肌苷片治疗老年脂肪肝的疗效,并观察对患者肝功能、血脂的影响。方法将在我院接受治疗的120例老年脂肪肝患者,分成对照组和观察组,患者接受常规治疗的同时,对照组口服肌苷片,观察组联合双环醇片治疗。结果治疗后,观察组患者TG、CHOL、LDL-C水平低于对照组、而观察组患者HDL-C水平高于对照组(P<0.05)。治疗后,观察组患者AST、TBil、ALT、GGT水平低于对照组(P<0.01)。观察组患者的治疗总有效率为95.00%,高于对照组(78.33%),(P<0.01)。结论双环醇片联合肌苷片治疗老年脂肪肝疗效佳,能够有效调节患者血脂、促进患者肝功能的恢复,有利于患者症状体征的改善。