中青年偏头痛患者经颅多普勒及脑干听觉诱发电位的变化

目的研究中青年偏头痛患者头痛发作期经颅多普勒(TCD)及脑干听觉诱发电位(BAEP)的变化。方法偏头痛组150例,对照组60例,分别行TCD检查,测定双侧大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)、椎动脉(VA)、基底动脉(BA)的平均血流速度(Vm)。偏头痛组行BAEP检查,测定I、III、V波潜伏期及I-III、III-V峰间期。结果双侧MCA、ACA、PCA、BA的Vm增快。偏头痛组病程越长,BAEP异常率越高,表现为III、V波潜伏期及I-III、III-V波峰间期延长。结论TCD、BAEP相结合,有助于偏头痛的诊断及脑功能情况的评定。     

项丛刺对脑梗死吞咽障碍患者脑干听觉诱发电位的影响

目的:观察项丛刺对脑梗死吞咽障碍患者脑干听觉诱发电位(BAEP)的影响,探讨项丛刺疗法的作用机制.方法:将80例脑梗死吞咽障碍患者随机分为项丛刺组、对照组,项丛剌组在药物治疗基础上,取风池、天柱、完骨、廉泉、旁廉泉、金津、玉液.风池、天柱、完骨震颤进针,针向喉结,留针30 min,廉泉、旁廉泉针向舌根直刺2寸,金津、玉液点刺放血(3天1次).对照组单纯药物治疗.结果:项丛刺组的总有效率达85％,对照组总有效率77.5％.愈显率项丛刺组为70％,对照组为35％,经统计学处理,P＜0.05,两组有显著差异,可见项丛刺组的疗效明显高于对照组.从BAEP变化看,治疗后两组均有明显变化,经统计学处理,P＜0.05,组间比较亦有显著差异.结论:项丛刺疗法可以调节脑梗塞BAEP,增加脑梗死病灶局部脑血流量,改善脑缺血状态,这也是项丛刺疗法治疗脑梗塞吞咽障碍的作用机制之一.     

脑干听觉诱发电位和经颅多普勒超声联合应用对后循环缺血的诊断价值

目的研究脑干听觉诱发电位(BAEP)和经颅多普勒(TCD)对后循环缺血(PCI)的联合诊断价值。方法对209例临床诊断为PCI患者进行脑干听觉诱发电位的检测;同时采用经颅多普勒探测基底动脉(BA)、椎动脉(VA)、大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)的血供情况、血管壁的弹性和顺应性。结果209例患者中BAEP异常和TCD异常共189例,总阳性率为90.43%。其中BAEP异常179例(85.65%);TCD阳性检出率169例(80.86%)。结论BAEP和TCD互为补充,可以分别从神经电生理方面和血流动力学来为PCI的诊断和定位提供有价值的客观依据。     

针刺任脉对脑梗塞假性延髓麻痹BAEP的影响

目的:探讨针刺任脉对脑梗塞假性球麻痹患者脑干听觉诱发电位(BAEP)的影响。方法:选择脑梗塞假性球麻痹患者42例,22例为治疗组;20例为对照组。应用肌电图诱发电位仪分析针刺治疗前后BAEPIII波和V波潜伏期(PL)、III~V和I~V峰间潜伏期(IPL)的变化。结果:治疗组BAEP各参数在治疗前比较无显著性差异(P>0.05),在治疗后III波和V波PL、III~V、I~VIPL分别与治疗前、对照组治疗后比较有显著性差异。结论:针刺任脉能促进脑梗塞假性球麻痹患者脑干听觉传导功能康复。     

新生儿高胆红素血症血清神经元特异性烯醇化酶检测的临床意义

目的通过检测新生儿高胆红素血症患儿血清神经元特异性烯醇化酶（NSE）的变化,探讨NSE诊断新生儿胆红素脑病的意义。方法 36名健康新生儿和96名本院新生儿室收治的高胆红素血症患者静脉采血利用化学发光法检测血清NSE水平,同时做脑干听觉诱发电位（BAEP）检测。结果 NSE异常患儿BAEP异常率在观察组与轻度升高、中度升高与重度升高各组间比较p〈0.05,差异具有统计学意义。在轻度升高组与中度升高组比较p〉0.05,差异无统计学意义。结论 NSE检测较BAEP测定能更早期诊断新生儿胆红素脑病。     

脑干诱发电位对自闭症患儿早期诊断的初步探讨

目的通过观察儿童孤独症患者脑干听觉诱发电位（BAEP）的变化,探讨BAEP在自闭症患儿早期诊断中的临床意义。方法应用日本光电5504肌电诱发电位仪进行BAEP检测,检查36例2～6岁自闭症患儿和36例同年龄组正常儿童的BAEPⅠ～Ⅴ各波潜伏期及潜伏期差。结果与正常组比较,自闭症患儿BAEP中的波Ⅴ绝对潜伏期延迟（p〈0．05）。结论BAEP对,临床辅助诊断自闭症患儿有一定参考价值,为患儿早期诊断提供帮助,值得继续随访。     

海洛因依赖事件相关电位的初步研究

目的：探讨海洛因依赖患者的认知改变情况。方法：采用1：1配对研究,分别测定了海洛因患者及正常人的脑听觉诱发电位。结果：海洛因依赖组Cz导联P300潜伏期延长,与正常对照组有显著性差异（P〈0．01）,波幅正常无明显差异。同时发现患者Cz、Pz导联的P300潜伏期与其吸入海洛因的量呈显著正相关,亦-9其最后一次海洛因吸入量呈正相关;而患者P300的潜伏期及波幅与其吸食海洛因的时间长短无关,P300潜伏期与其最后一次海洛因吸入时间也无关。结论：海洛因依赖患者可能存在某种程度的认知损害,其认知损害的程度与海洛因吸入总量呈正相关。     

Findings confirming brainstem generators of auditory evoked potentials by stereotactic lesions in the rabbit

The origin of brainstem auditory evoked potentials (BAEP) was rnvestigated experimentally with morphologically verified stereotactic lesions in eleven rabbits. Waves were recorded before and after thermocoagulation. The loss of waves III and V following coagulation in the inferior colliculus and the upper pons respectively, supports Jewett's hypothesis.     

脑干听觉诱发电位对新生儿高胆红素血症检测的临床意义

目的：通过脑子听觉诱发电住（BAEP）对新生儿高胆红素血症的测定,了解高胆红素对新生儿中枢神经系统的损害。方法：采用ZABR－200型脑干反应别听仪对100例新生儿高胆红素血症进行检查,并以30例新生儿肺炎作对照现查。结果：两组相比,X~2＝MM,P＜0．001观察组BAEP正常42例（42％）,异常58例（58％）。结论：不同程度高胆红素血症均可引起中枢神经系统损害,胆红素越高BAEP异常率越高,且异常程度越重。BAEP敏感性高,影响因素小,结果准确可靠,为胆红素听觉传导通路神经毒性作用的判断指标。     

Brainstem auditory evoked potential combined with high resolution cranial base CT can optimize the diagnosis of auditory nerve injury

PurposeAuditory nerve injury is one of the most common nerve injury complications of skull base fractures. However, there is currently a lack of auxiliary examination methods for its direct diagnosis. The purpose of this study was to find a more efficient and accurate means of diagnosis for auditory nerve injury.MethodsThrough retrospectively analyzing the results of brainstem auditory evoked potential (BAEP) and high-resolution CT (HRCT) in 37 patients with hearing impairment following trauma from January 1, 2018 to July 31, 2020, the role of the two inspection methods in the diagnosis of auditory nerve injury was studied. Inclusion criteria were patient had a clear history of trauma and unilateral hearing impairment after trauma; while exclusion criteria were: (1) severe patient with a Glasgow coma scale score ≤5 because these patients were classified as severe head injury and admitted to the intensive care unit, (2) patient in the subacute stage admitted 72 h after trauma, and (3) patient with prior hearing impairment before trauma. According to Goodman's classification of hearing impairment, the patients were divided into low/medium/severe injury groups. In addition, patients were divided into HRCT-positive and negative groups for further investigation with their BAEP results. The positive rates of BEAP for each group were observed, and the results were analyzed by Chi-square test (p < 0.05, regarded as statistical difference).ResultsA total of 37 patients were included, including 21 males and 16 females. All of them were hospitalized patients with GCS score of 6–15 at the time of admission. The BAEP positive rate in the medium and severe injury group was 100%, which was significantly higher than that in the low injury group (27.27%) (p < 0.01). The rate of BEAP positivity was significantly higher in the HRCT-positive group (20/30, 66.7%) than in the HRCT-negative group (1/7, 14.3%) (p < 0.05). Twenty patients (54.05%) were both positive for BEAP and HRCT test, and considered to have auditory nerve damage. Six patients (16.22%) were both negative for BEAP and HRCT test, and 10 patients (27.03%) were BAEP-negative but HRCT-positive: all the 16 patients were considered as non-neurological injury. The rest 1 case (2.70%) was BAEP-positive but HRCT-negative, which we speculate may have auditory nerve concussion.ConclusionBy way of BAEP combining with skull base HRCT, we may improve the accuracy of the diagnosis of auditory nerve injury. Such a diagnostic strategy may be beneficial to guiding treatment plans and evaluating prognosis.