参芎注射液对腹膜透析患者转化生长因子β1的影响

目的观察参芎注射液对腹膜透析患者转化生长因子β1(TGFβ1)及腹膜功能的影响。方法选择2012年12月至2014年5月我院肾内科进行腹膜透析的60例患者,随机分为2组:常规腹膜透析组(对照组)和参芎注射液腹膜透析组(观察组),每组30例。比较两组相关临床和生化指标,应用ELISA法检测TGFβ1表达。结果治疗前,两组肌酐透析液与血浓度之比(D/Pcr)、尿素清除指数(KT/V)、肌酐清除率(Ccr)、尿量和超滤量比较差异无统计学意义(P>0.05)。治疗后,对照组上述指标无显著变化(P>0.05);观察组D/Pcr、KT/V、Ccr、尿量与治疗前比较差异无统计学意义(P>0.05),但超滤量升高(P<0.01)。两组血浆白蛋白(ALB)、钙(Ca)、磷(P)、甲状旁腺素(iP TH)在治疗前、后比较差异均无统计学意义(P>0.05)。治疗前,两组TGFβ1表达水平比较差异无统计学意义(P>0.05);治疗后,对照组TGFβ1表达无显著变化(P>0.05),但观察组显著减低(P<0.01)。结论参芎注射液可显著提高腹透患者的超滤量,抑制腹膜细胞的TGFβ1分泌,具有抗腹膜纤维化的功效。     

热毒宁治疗急性肠炎发热疗效观察

目的：观察热毒宁治疗腹泻发热的疗效。方法我院急诊2013年1月-2013年12月就诊的肠炎发热患者82例，将患者随机分为观察组（41例）和对照组（41例）。对照组给予对症处理，观察组在对照组的基础上，静脉滴注热毒宁注射液20 mL，1次/d。两组疗程均为3d。结果观察组治愈36例，好转4例，无效1例；对照组治愈23例，好转9例，无效9例。两组疗效比较差异有统计学意义（P＜0.05）。结论热毒宁注射液治疗急性肠炎发热疗效显著。     

股权激励契约设计与公司盈余管理行为

以2006年公告股权激励方案的上市公司为研究对象，运用其股权激励方案公告后3年的相关数据，基于应计项目与线下项目盈余管理的双重计量视角，实证分析股权激励契约的设计对激励后公司盈余管理方式与强度的影响。研究发现：股权激励方案公告后，相关公司应计项目和线下项目的盈余管理都存在，且公司管理层倾向于实施应计项目盈余管理方式。相对于实施业绩股票模式的公司，实施股票期权模式公司的线下项目盈余管理会显著减少，而应计项目盈余管理减少不明显。激励规模越大，行权条件设计的越严格，无论是应计项目还是线下项目盈余管理均会增强。激励计划的有效期设计的越长，线下项目盈余管理会显著减少，应计项目盈余管理减少不明显。     

丹红注射液对肾病综合征患者肾血流动力学及血液黏稠状态的影响研究

目的探讨丹红注射液对肾病综合征患者肾血流动力学及血液黏稠状态的影响。方法选取2008年7月～2010年12月于某院进行治疗的64例初发原发肾病综合征患者为研究对象,将其随机分为对照组和观察组各32例,对照组采用泼尼松联合双嘧达莫进行治疗,观察组在对照组的基础上加用丹红注射液进行治疗,后将两组患者治疗前及治疗后4周的肾动脉血流动力学及血液流变学指标进行对比。结果治疗后观察组的肾动脉血流动力学及血液流变学指标的改善幅度均大于对照组,治疗后两组上述检测项目比较,P均﹤0.05,差异均有统计学意义。结论丹红注射液在改善肾病综合征患者肾血流动力学及血液黏稠状态方面均发挥着积极的作用,对于改善肾脏血液循环效果明显。     

乳腺癌Survivin表达意义及苦参临床疗效分析

目的:探讨乳腺癌（breast cancer，BC）Survivin表达与以紫杉醇为主的化疗疗效之间的关系，并进一步研究复方苦参注射液对化疗疗效的影响。方法:筛选119例乳腺癌患者，通过回顾性分析，依据既往用药情况分为:含紫杉醇化疗组（A组）和化疗联合复方苦参注射液组（B组）。应用免疫组化法检测患者肿瘤组织中Survivin表达水平，再分为阳性表达组和阴性表达组。分别以χ2检验和Kaplan-Meier方法分析有效率和生存时间的差异。结果:A组阴性表达患者化疗有效率为83.3%，明显高于阳性表达组（P=0.031）；且PFS、OS均较阳性组延长，但仅PFS差异具有统计学意义（P=0.046）。B组阳性表达与阴性表达者在化疗有效率、PFS、OS方面均无明显差异。两组之间比较发现:联合苦参B组阳性表达患者有效率较单纯化疗A组阳性表达者有明显升高趋势(P=0.026)。阳性表达者PFS在联合苦参后由12.761月提高到16.197月，具有统计学差异（P=0.027）。OS由30.789月提高到36.570月，但差异并没有统计学意义（P>0.05）。结论:对Survivin表达水平的检测有望成为乳腺癌含紫杉醇化疗方案的预测指标，且针对Survivin高表达患者联合复方苦参注射液可能提高化疗的有效率，甚至延长PFS。     

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??Objective??To find the difference in growth and development of children between full-term symmetric growth restriction??FSGR?? and full-term asymmetric growth restriction??FAGR?? through a general investigation of children born small for gestational age in Shanghai. Methods??This general investigation covered all children under 6 years old in Shanghai. Data on growth were retrospectively obtained from medical records. The P10 of birth head circumference/birthweight of the same gestational age and gender was used to distinguish FSGR and FAGR. Results??The sample contained 10 188 full-term SGA children among whom 8049 were FAGR and 2139 were FSGR. Up to 3 years old??both FSGR and FAGR failed to catch up in weight??height??head circumference and chest circumference. Growth restriction in FAGR was more serious. Significant difference could be seen in weight??t??-3.412??P??0.001?? and chest circumference??t??-2.526??P??0.012?? between FSGR and FAGR at 3 years old. Regarding growth speed??the growth rate of weight ??t??6.272??P??0.001????height ??t??9.143??P??0.001????head circumference ??t??6.063??P??0.001?? and chest circumference ??t??6.617??P??0.001?? were higher in FAGR 6 months after birth??while there was no difference after that. The BMI of FAGR was significantly lower than FSGR before 2 years old. The proportion of children in danger of being overweight was significantly higher in FSGR ??P??0.001??. Conclusion??Both FSGR and FAGR experience catch-up growth after birth??but not enough to catch up with normal children at 3 years old??especially in head circumference. In spite of severer growth restriction??the cath-up growth model of FAGR is superior to FSGR. The proportion of children in danger of being overweight is significantly higher in FSGR.     

Tumor Epigenetic Signature and Survival in Resected Gastric Cancer Patients

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The Montana Adaptive Equipment Project:

A statewide service delivery project which provides specialized adaptive equipment to multi-handicapped persons living in rural communities is described. In addition to client consultation regarding motor programs, the adaptive equipment project provided specialized equipment such as adaptive chairs, standing and walking aids, feeding utensils, bathing aids, etc. to handicapped client of all ages. Services were delivered via an itinerant approach and relied on parents and others in the community as primary intervention agents. The project is viewed as an important activity in maintaining recently deinstitutionalized clients in community settings.