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91.
《Journal of clinical neuroscience》2014,21(2):236-240
Approximately 25% of patients undergoing carotid endarterectomy (CEA) exhibit cognitive dysfunction (CD) 1 day and 1 month after CEA. The apolipoprotein E (apoE)-ε4 polymorphism has been previously identified as a robust independent risk factor for CD 1 month after CEA. We aimed to determine whether the apoE-ε4 polymorphism is also an independent risk factor for CD as early as 1 day after CEA and to confirm the previous findings at 1 month. Patients undergoing elective CEA (n = 411) were enrolled with written informed consent in this follow-up observational study. CD was evaluated via an extensive neuropsychometric battery. apoE-ε4 carriers exhibited significantly more CD 1 day (30.1% versus 17.9%, p = 0.01) and 1 month (25.7% versus 9.8%, p = 0.001) after CEA compared to non-carriers. Multivariate regression models were generated to determine independent predictors of CD. At 1 day, apoE-ε4 was significantly associated with higher risk of CD (odds ratio [OR]: 2.24 [95% confidence interval 1.29–3.84], p = 0.004), while statin use was significantly associated with lower risk (OR: 0.40 [0.24–0.67], p < 0.001). At 1 month, apoE-ε4 was significantly associated with higher risk of CD (OR: 3.14 [1.53–6.38], p = 0.002), while symptomatic status was significantly associated with lower risk (OR: 0.45 [0.20–0.94], p = 0.03). The apoE-ε4 polymorphism is an independent risk factor for CD as early as 1 day after CEA and is confirmed to be an independent risk factor for CD at 1 month as well. 相似文献
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93.
老年人血脂水平与载脂蛋白E等位基因的关系 总被引:8,自引:0,他引:8
为了解老年人血脂水平与载脂蛋白E基因多态性的关系,并探讨载脂蛋白E等位基因对老年人血脂水平的内在影响,利用PCR-RFLP法测定了载脂蛋白E基因型,并用酶学方法对其血脂水平进行了测定。结果发现存在五种不同基因型:与携有ε3等位基因的人群相比,携有ε4等位基因的人群倾向具有较高的总胆固醇和低密度脂蛋白胆固醇水平以及较低的甘油三酯水平,而携有ε2等位基因的人群则有较低的低密度脂蛋白胆固醇水平以及较高的 相似文献
94.
为建立人周围血单核细胞载脂蛋白E基因表达检测方法,研究载脂蛋白E基因与儿童健康的关系,我们抽取26例健康儿童外周静脉血,分离血单核细胞,抽提RNA,采用逆转录-聚合酶链式反应检测载脂蛋白E基因表达,并以正常人cDNA作定量标准物,待测样品与定量标准物共扩增,计算出待测样本的个体的mRNA量.研究发现载脂蛋白E基因能在健康儿童周围血单核细胞表达,健康儿童载脂蛋白E基因表达量为0.37±0.15 mol/mol mRNA.表明采用竞争性逆转录-聚合酶链反应方法来检测人周围血单核细胞载脂蛋白E基因表达的分析方法快速、简便、灵敏、实用、可靠,且能准确定量,值得推广应用. 相似文献
95.
本文对60例糖尿病患者及62例正常人的血清载脂蛋白(Apo)-Al,Apo-B高密度脂蛋白(HDL)和低密度脂蛋白(LDL)水平进行了测定,结果显示:(1)糖尿病患者Apo-Al水平和Apo-B水平均明显高于正常人(P<0.01)。(2)住院治疗前,糖尿病患者血清HDL水平明显低于正常人(P<0.01)。(3)住院治疗期间糖尿病患者血清HDL水平显著增高(P<0.01),而LDL水平无明显改变(P>0.05)。 相似文献
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97.
Min-Ho Shin Jin-Su Choi Jung-Ae Rhee Young-Hoon Lee Hae-Sung Nam Seul-Ki Jeong Kyeong-Soo Park Hye-Yeon Kim So-Yeon Ryu Seong-Woo Choi Hee Nam Kim Hye-Rim Song Jane A. Cauley Sun-Seog Kweon 《Atherosclerosis》2014
Objective
We evaluated the association between APOE polymorphism and carotid atherosclerosis in two large independent cohorts from South Korea.Methods
The datasets were from the Dong-gu Study (N = 9056) and the Namwon Study (N = 10,158). Carotid ultrasonography was performed to measure carotid intima-media thickness (IMT) and the presence of carotid plaques. The APOE polymorphism was determined by PCR-RFLP. We performed combined and separate analyses for the two datasets.Results
In the combined analysis, individuals with E2E2 or E2E3 genotype had a lower common carotid IMT compared with individuals with E3E3 genotype (0.684 mm vs. 0.736 mm, p = 0.007; 0.718 mm vs. 0.736 mm, p < 0.001, respectively). This association was very slightly attenuated but remained statistically significant after adjustment for blood lipids (0.690 mm vs. 0.736 mm, p = 0.033; 0.725 mm vs. 0.736 mm, p = 0.005, respectively). Compared with individuals with E3E3 genotype, individuals with E2E3 genotype had lower risk for carotid plaque (odds ratio (OR) = 0.83, 95% confidence interval (CI) = 0.75–0.93), while individuals with E3E4 genotype had a higher risk for carotid plaque (OR = 1.09, 95% CI = 1.00–1.20). After adjustment for blood lipids, ORs of E2E3 genotype for carotid plaque was slightly attenuated but remained significant (OR = 0.87 95% CI = 0.78–0.97), while OR of E3E4 genotype were slightly attenuated and not significant (OR = 1.08, 95% CI, 0.99–1.18).Conclusions
We found that APOE polymorphism is associated with carotid atherosclerosis and this association was partly mediated through blood lipid. Our results suggest that APOE polymorphism may influence atherosclerosis through non-lipid pathways. 相似文献98.
Ana Cenarro José Puzo Juan Ferrando Rocío Mateo-Gallego Ana M. Bea Pilar Calmarza Estíbaliz Jarauta Fernando Civeira 《Metabolism: clinical and experimental》2014
Background
Lipoprotein(a) [Lp(a)] is a lipoprotein in which apolipoproteinB-100 is linked to apolipoprotein(a) [apo(a)]. Significant variation in Lp(a) concentration is specific to LPA gene, which codes for apo(a). Nicotinic acid (NA) is used for treatment of dyslipidemias, and the lowering effect of NA on Lp(a) has been previously reported.Objective
To evaluate the Lp(a) lowering effect of 1 g/20 mg and 2 g/40 mg day of Nicotinic acid/Laropiprant in subjects with different baseline Lp(a) concentrations and depending on the LPA genotype.Methods
In an open-label, 10-week study, 1 g/20 mg day of NA/Laropiprant for 4 weeks followed by 6 weeks of 2 g/40 mg day conducted at 3 centers in Spain, 82 subjects were enrolled. Patients were studied at baseline and at the end of both treatment periods and were enrolled in three groups: normal Lp(a) (< 50 mg/dL), high Lp(a) (50–120 mg/dL) and very high Lp(a) (> 120 mg/dL). The LPA genetic polymorphism was analyzed by a real-time PCR.Results
There was a significant difference in LPA genotypes among Lp(a) concentration groups and an inverse and significant correlation between baseline Lp(a) concentration and LPA genotype was found (R = − 0.372, p < 0.001). There were a significant decrease in total cholesterol, triglycerides, LDL cholesterol, apo B and Lp(a), and a significant increase in HDL cholesterol after NA/Laropiprant treatment, without changes in BMI. However, there were no statistical differences in percentage variation of analyzed variables depending on LPA genotype.Conclusion
LPA genotype is a major determinant of Lp(a) baseline concentration. However, the lipid lowering effect of NA is not related to LPA genotype. 相似文献99.
100.