高效液相色谱法测定阿苯达唑的含量

目的:建立高效液相色谱法测定阿苯达唑的含量。方法:采用Lichrospher 100 RP-18(5μm,250mm×4mm)柱。以甲醇-0.1 mol/L醋酸钠缓冲液(用醋酸调节pH=3.1)(60:40)为流动相,用紫外检测器于254nm波长处检测。结果:阿苯达唑浓度在0.1～0.8mg/ml范围内有较好的线性关系(r=0.9992),RSD=0.5％(n=6)。结论:本法快速简便,准确。     

Ultrasound changes in abdominal echinococcosis treated with albendazole.

Fifty patients with 81 abdominal hydatid cysts were followed with ultrasound during and after treatment with albendazole. In 61 cysts (75%), regressive changes were observed after treatment. Detachment of the membrane and change to a solid pattern in anechoic cysts were observed. Disappearance of septa or change to a solid pattern in anechoic cysts with intracystic septation were also found. There was an increase of hyperechoic structures in cysts with a mixed pattern. Follow-up ultrasound examination showed disappearance of 7 cysts, while anechoic structures reappeared in five cases. In anechoic cysts, regressive changes due to albendazole seem to be permanent, but in cysts with a mixed pattern recurrences are sometimes observed.     

旋毛虫病人治疗后血清抗体水平的变化

应用旋毛虫幼虫冰冻切片抗原间接荧光抗体试验（ＩＦＡＴ）观察了旋毛虫病人阿苯哒唑治疗后血清抗体水平的变化。结果表明，治疗后抗体阳性率及抗体滴度均比治疗前明显升高，此现象可作为一种治疗有效的客观指标。此外，对旋毛虫病人及时治疗也可将检测到抗体的时间提前１￣２周。旋毛虫病人从治疗后１个月开始抗体水平明显下降，至治疗后４个月时抗体转阴率已达７５％。因此，ＩＦＡＴ对旋毛虫病的近期及远期疗效考核均有一定价值。     

109例旋毛虫病临床资料分析

目的分析旋毛虫病发病机制、临床表现、诊断、治疗及预防。方法分析1999～2008年109例旋毛虫病患者临床资料。结果患者治愈率达100%,副反应发生率低。结论旋毛虫病诊断容易,阿苯达唑疗效肯定,阻断流行应加强预防措施。     

An extensive vertebral hydatidosis revealed by a lumbosciatica

The vertebral hydatidosis is uncommon. It causes problems in diagnosis and in management. A case of an extensive vertebral hydatidosis with few symptoms is reported. A 21-year-old man has consulted for recurrent lumbosciatica that has been evolving for 1 year. Clinical exam was normal. Plain radiographic films disclosed a lytic lesion throughout the bodies of L4 and L5 and calcifications thrown on the liver area. The computed tomography (CT) and the magnetic resonance (MR) images revealed multicystic bony lesions involving the lumbar spine with extension into the spinal canal. Abdominal ultrasound showed also cyst lesions in the right kidney and in the liver. The diagnosis of vertebral and abdominal (liver and kidney) hydatidosis was retained. Four sets of 4-week albendazole cures were given with a 2-week interval in between. Our case of extended vertebral hydatidosis with few symptoms confirms the clinical latency and diagnosis difficulties usually encountered in this disease. This often leads to a late diagnosis of the stage of spinal cord compression. Radiological diagnosis and determination of extension of the hydatid cyst are usually provided by CT and MRI. Vertebral hydatidosis should be evoked in lumbosciatica especially in endemic regions.     

阿苯达唑及黄芪对肝吸虫病大鼠红细胞免疫功能的影响

目的 观察药物阿苯达唑联合中药黄芪对肝吸虫感染大鼠的治疗效果并探讨其作用机制。方法 取健康成年Wistar大鼠32只,随机分为对照组、感染组、阿苯达唑治疗组和阿苯达唑联合黄芪治疗组,每组8只大鼠。对肝吸虫病大鼠感染及治疗前后红细胞C3b受体花环率（RBC-C3bRR）,红细胞免疫复合物花环率（RBC-ICR）,血清红细胞免疫促进因子（RFER）和红细胞免疫抑制因子（RFIR）活性进行检测。结果 大鼠感染肝吸虫后RBC-C3bRR和RFER水平下降,RBC-ICR和RFIR水平升高,与正常对照组比较,差异有统计学意义。经阿苯达唑及黄芪治疗后,肝吸虫病大鼠RBC-C3bRR和RFER水平升高,RBC-ICR和RFIR水平下降,与感染组比较差异有统计学意义;与阿苯达唑单独治疗组比较,阿苯达唑联合黄芪治疗肝吸虫病的效果更显著。结论 红细胞免疫功能在肝吸虫病大鼠致病过程中具有重要的作用,药物阿苯达唑和黄芪对肝吸虫病大鼠具有较好的疗效,中药黄芪对红细胞免疫具有调节作用。     

200例脑囊虫病疗效及不良反应分析

目的 评价阿苯达唑、吡喹酮治疗脑囊虫病的疗效及不良反应.方法 将2002-2007年收治的脑囊虫病病例资料,随机抽取200例,分单纯使用阿苯达唑治疗组58例和吡喹酮、阿苯达唑联合治疗组142例两组,进行上述目的 分析.结果 治疗后两组临床有效率差异无统计学意义(P>0.05);颅内高压症、癫痫发作、精神症状的不良反应发生率阿苯达唑组少于联合治疗组,差异有统计学意义(P<0.05);过敏反应两组差异无统计学意义(P>0.05).结论 阿苯达唑、吡喹酮治疗脑囊虫病疗效肯定,但吡喹酮和阿苯达唑联合用药的不良反应较阿苯达唑单独用药严重.     

Management of multiple echinococcosis in childhood with albendazole and surgery

Background/Purpose

Multiple echinococcosis (ME) is a severe disease in childhood inaccessible to an initial radical surgical treatment. The aim of this study was to evaluate the efficacy of Albendazole in ME and to discuss the role of surgery in this pathology.

Methods

Eleven patients were included in a prospective study between 1996 and 2004. ME was defined by the presence of 10 or more cysts in the same organ. Albendazole was given as 10 mg/kg daily continuously.Treatment outcome was defined as cure, improvement, stabilization or deterioration. Surgery was discussed after 1 year of treatment.

Results

Our patients totalized 296 cysts located essentially on the liver (178 cysts) and the lungs (78 cysts). With exclusive Albendazole therapy, 57.7% pulmonary cysts and 96% peritoneal cysts were considered as cured. This rate was only 31.5% in hepatic localization. After surgical therapy, 67.4% of hepatic cysts were cured. No productive biliary fistula was observed. Two patients were operated laparoscpically. The total treatment duration ranged between 1 and 5 years. Parasitologic examination of operated cysts showed that 30% of them were viable even after 3 years of treatment.

Conclusion

Albendazole has proven a strong efficacy in pulmonary and peritoneal localizations. A complementary surgical treatment is often necessary in hepatic localizations and it is facilitated with previous Albenazole therapy. Combination of ABZ and surgery seems to have encouraging results and must be applied for those patients. The high rate of viable cysts after medical therapy is problematic and must incite to develop new antihelminthic agents.     

Management of liver hydatid cysts – Current perspectives

Human hydatid disease or cystic echinococcosis (CE), caused by the larval form of cestode Echinococcus granulosus still continues to a common problem in health care environments as different as Europe/North America and resource poor countries of the South America and the East. The Liver is the most frequently parasatized organ in humans. While ultrasonography remains the main diagnostic tool, computed tomography and serology improve the accuracy of diagnosis in Liver hydatid cysts (LHC). Although surgery is the only modality applicable over the entire spectrum of the disease, systemic chemotherapy and percutaneous drainage have evolved as alternative therapies in the last three decades. Various laparoscopic techniques have also been described for safe and optimal management of this entity. In this paper, we review the current management procedures of LHC with particular emphasis on the evidence base and setting specific problems.     

复方制剂中双羟萘酸噻嘧啶及阿苯达唑含量测定方法的研究

本文采用双波长法分别测定驱虫药复方制剂的有效成份双羟萘酸噻嘧啶及阿苯达唑，进行了方法学研究、线相关系、加样回收等实验工作，两种效成分的回收率分别为１００．６±０．６８％，９９．２７±０．５９％（ｎ＝２），含量在其标示量的±２０％范围内线性关系良好，分别为ｒ＝０．９９９９，ｒ＝－９９９８。