唐汉钧辨证分型治疗痤疮的经验

唐汉钧以肺脾肾并重，辨证辨病相结合治疗痤疮，取得良好疗效。     

痤疮颗粒的药效学研究

目的：研究痤疮颗粒的作用机理。方法：用放射免疫法测定大鼠血清睾酮浓度，测算大鼠睾丸、附睾、精囊、前列腺系数，观察痤疮颗粒对性激素的影响；分别进行二甲苯致小鼠耳廓肿胀实验，醋酸所致小鼠毛细血管通透增加实验，观察该药的抗炎作用。结果：痤疮颗粒能够降低丙酸睾酮（TP）引起的未成熟大鼠血清睾酮的升高，降低其附睾、精囊、前列腺的重量；降低醋酸所致小鼠腹腔毛细血管的通透性；减轻二甲苯所致小鼠耳廓的肿胀。结论：痤疮颗粒能够调节体内激素分泌，缓解二甲苯致小鼠耳廓肿胀程度，减轻醋酸所致小鼠毛细血管通透性增加现象。     

中药金贯蓝提取物对寻常痤疮相关致病菌的体外抑菌作用

目的 考察自主研发的协定方中药“金贯蓝”提取物对寻常痤疮三种主要致病菌（痤疮丙酸杆菌、表皮葡萄球菌、金黄色葡萄球菌）的体外抑菌效果,为其临床治疗寻常痤疮提供一定实验依据。方法 2021年1月至2022年3月采用琼脂打孔法考察金贯蓝提取物对三种痤疮相关致病菌的抑菌活性,并评估不同浓度药物对上述菌的抗菌作用是否具有浓度相关性;采用倍比稀释法测定药物最低抑菌浓度以及最小杀菌浓度,绘制药物时间抑菌曲线进一步考察其作用特点。结果 500 g/L金贯蓝提取物对C. acnes、S. epidermidis、S. aureus的抑菌圈直径分别为（27.67±2.52）mm、（23.33±1.53）mm、（22.00±1.00）mm;浓度为250 g/L金贯蓝提取物对C. acnes、S. epidermidis、S. aureus的抑菌圈直径分别为（22.33±0.58）mm、（20.67±1.53）mm、（20.11±1.20）mm;浓度为100 g/L金贯蓝提取物对C. acnes、S. epidermidis、S. aureus的抑菌圈直径分别为（13.30±0.75）mm、（10.67±1....     

丹参胶囊祛痤疮效果的评价

目的:对丹参胶囊祛痤疮效果进行评价。方法:用组间对照和自身对照法观察丹参对痤疮患者的临床疗效,并对其功能进行评价。结果:试食期间各组人员未见明显不良反应,试食后丹参胶囊组痤疮数量减少27.02%,皮损积分变化明显,平均减少0.54,前后比较及与对照组比较差异有显著性(P<0.05);试食组总有效率为45.1%,与对照组(7.84%)比较,差异有胶囊显著性(P<0.05),皮肤油份未见明显改变。结论:丹参胶囊具有祛痤疮的功能。     

Effect of isotretinoin treatment on the inflammatory markers in patients with acne vulgaris: can monocyte/HDL be a new indicator for inflammatory activity of isotretinoin treatment?

Abstract

Background: Oral isotretinoin (ISO) can effect markers of inflammation in patients with acne vulgaris. To our knowledge, there are no data on the relationship between ISO and monocyte to HDL cholesterol ratio (MHR). In this study, it is aimed to examine the effect of the ISO treatment on the MHR and other inflammatory markers in patients with acne vulgaris.

Materials and methods: In this study, 89 out of 120 patients with severe/very severe acne vulgaris according to the Global Acne Grading Scale who received at least 3 months of ISO treatment were evaluated. The complete blood counts including mean levels of mean platelet volume, plateletcrit (PTC), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), MHR, and serum biochemistry panel were evaluated before and after ISO treatment.

Results: The mean platelet value, NLR, and PLR levels underwent a statistically significant decrease after ISO treatment (p?<?0.05) while MHR increased significantly 3 months after ISO treatment (p?=?0.017). The mean platelet value, NLR, and PLR levels were 9.56?±?1.05, 2.15?±?0.81, and 142.45?±?48.33 before treatment while were 9.32?±?1.45, 1.90?±?0.99, and 127.94?±?41.38 after treatment, respectively. On the other hand, MHR was 9.76?±?4.27 and 10.86?±?4.12 before and after treatment, respectively.

Conclusions: In this study, we found that ISO may have both inflammatory and anti-inflammatory effects by using MPV, PTC, NLR, PLR, and MHR. The inflammatory effects of ISO may be associated with possible inflammatory diseases. MHR can be used as a novel marker to investigate the inflammatory effect of the ISO.     

Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts

Background

The main pathogenesis of acne vulgaris is increase in sebum production and abnormal keratinization of the hair infundibulum. The androgens are involved in acne pathogenesis by modulating sebaceous glands to enhance sebum production. However, the molecular mechanisms of abnormal keratinization of the hair infundibulum are not fully elucidated.

雄激素受体基因CAG多态性与囊肿型痤疮的相关性研究

目的探讨雄激素受体基因CAG多态性与湖南汉族囊肿型痤疮的相关性。方法对寻常型和囊肿型痤疮患者及正常人的雄激素受体基因阳性PCR产物进行测序,测序结果应用Web Angis分析。结果寻常型痤疮患者的雄激素受体基因CAG微卫星片段长度的平均值为22．89±1．94,囊肿型痤疮患者为19．12±1．81,正常人为23．15±2．2;囊肿型组与寻常型组比较有显著性差异（t=8．41,P〈0．05）,与正常人组比较有显著性差异（t=8．23,P〈0．05）;而寻常型组与正常人组比较无显著性差异（t=0．528,P〉0．05）。以（CAG）n重复片段〈22为标准进行统计分析,囊肿型组与寻常型组比较有显著性差异（Х^2=45．17,P〈0．05）,与正常人组比较有显著性差异（Х^2=48．52,P〈0．05）;而寻常型组与正常人组比较无显著性差异（Х^2=0．06,P〉0．05）。结论雄激素受体基因CAG多态性与湖南汉族囊肿型痤疮之间有相关性。当（CAG）n重复片段〈22时,患囊肿型痤疮的风险增大。     

火针治疗痤疮574例临床疗效观察

目的:探讨火针治疗痤疮的临床疗效。方法:运用火针,取局部阿是穴、背部腧穴进行治疗。结果:574例痤疮患者治疗4个疗程后完全痊愈302例(52.53%),显效134例(23.26%),好转85例(14.90%),无效53例(9.32%),总有效率为90.68%。结论:火针对各型痤疮、皮损均有显著疗效,值得临床推广。     

五味枇杷饮治疗痤疮52例

痤疮在中医称"粉刺",是毛囊与皮脂腺慢性炎症性皮肤病。近两年来,笔者对54例座疮病患者运用五味枇杷饮进行治疗,取得了满意效果。