异维A酸联合火针治疗结节囊肿型痤疮的临床疗效与皮肤超声评估

探讨异维A酸联合火针治疗结节囊肿性痤疮的疗效,分析火针治疗前后的皮肤激光共聚焦 扫描显微镜及皮肤超声的成像特征。方法 选取我院2023年1月-6月收治的87例结节囊肿型痤患者为研究对 象,采用随机数字表法分为对照组（47例）和观察组（40例）。对照组予以口服异维A酸治疗,观察组予 以异维A酸联合火针治疗,比较两组临床疗效,并采用皮肤激光共聚焦扫描显微镜及皮肤超声观察治疗前 后镜下变化。结果 两组治疗后2、4周治疗总有效率比较,差异无统计学意义（P ＞0.05）,观察组治疗后 6、8周治疗总有效率高于对照组,差异有统计学意义（P＜0.05）;皮肤激光共聚焦扫描显微镜下粉刺表现 为毛囊失去原有的结构,真皮浅层有圆形低折光性的栓塞,皮肤超声可见结节囊肿性皮损表现为皮下的混 合回声等影像学特征,火针治疗后,共聚焦激光扫描显微镜下可见真表皮曾恢复正常结构,部分可见真皮 乳头边缘有较多高着光物质;皮肤超声下结节囊肿可见明显的消退不留痕迹。结论 异维A酸联合火针治 疗痤疮的起效更快,疗效确切。皮肤激光共聚焦扫描显微镜及皮肤超声可用于判断火针治疗痤疮的疗效。     

Male Testosterone Does Not Adapt to the Partner's Menstrual Cycle

Background

It has not yet been established whether men in heterosexual relationships adapt their hormone levels to their female partner's menstrual cycle to allocate reproductive resources to the period when the female is actually fertile.

异维A酸对肽聚糖诱导的SZ95人皮脂腺细胞相关炎症基因表达的影响

目的 观察异维A酸体外对肽聚糖诱导的SZ95人皮脂腺细胞中与痤疮发病可能相关的炎症基因表达的影响,探讨异维A酸治疗痤疮的分子机制。方法 将培养的SZ95细胞分成3组,对照组不做处理,另外两组用20 mg/L肽聚糖单独（肽聚糖组）或联合10-5 mol/L异维A酸（共刺激组）共同处理。作用3 h后,实时荧光定量PCR检测上述各组SZ95细胞中白细胞介素（IL）-1α、IL-1β、IL-6、IL-8、肿瘤坏死因子α（TNF-α）以及Toll样受体2（TLR2）和其下游基因MyD88 mRNA表达水平;作用24 h后酶联免疫吸附试验检测各组细胞培养上清液中IL-1α、IL-1β、IL-6、IL-8、 TNF-α蛋白表达水平;作用48 h后Western印迹检测TLR2和MyD88蛋白表达水平。采用SPSS 23软件, 3组间指标的比较采用单因素方差分析,并采用Bonferroni校正进行两两比较。结果 对照组、肽聚糖组和共刺激组IL-1α、IL-1β、IL-6、IL-8及TNF-α mRNA和蛋白表达水平差异均有统计学意义（均P < 0.01）;其中,肽聚糖组上述指标均高于对照组及共刺激组,差异均有统计学意义（均P < 0.016 7）。上述3组间MyD88 mRNA表达差异也均有统计学意义（分别为6.707 ± 0.950、10.270 ± 0.477、7.892 ± 0.900,F = 10.17,P < 0.01）,肽聚糖组高于对照组及共刺激组,差异均有统计学意义（t值分别为4.740、3.298,均P < 0.016 7）。肽聚糖组TLR2 mRNA和蛋白表达水平均高于对照组,但与共刺激组比较差异无统计学意义。结论 异维A酸抑制肽聚糖诱导的SZ95人皮脂腺细胞中与痤疮发病可能相关的炎症因子的表达,其机制可能是通过抑制天然免疫应答中MyD88的表达而非TLR2本身,这可能是异维A酸治疗痤疮的机制之一。     

基于面部不同埋线方法的综合针灸疗法治疗女性青春期后痤疮的疗效及其作用机制

背景　痤疮是青春期常见的毛囊皮脂腺的慢性炎症性疾病,青春期后女性患者较多,皮疹持续时间较长,严重影响患者容貌美观和身心健康。常规埋线对女性青春期后痤疮有较好疗效,而平滑线埋线是基于浅筋膜理论的一种埋线方法,目前临床尚无两种埋线方法的疗效比较研究。目的　探讨基于面部不同埋线方法的综合针灸疗法治疗女性青春期后痤疮的疗效及其作用机制。方法　选取2015年7月—2017年7月连云港市第一人民医院针灸科门诊收治的女性青春期后痤疮患者61例,分为平滑线组31例和常规埋线组30例。两组均接受综合针灸疗法,在此基础上平滑线组于2次体穴埋线后第2周予平滑线埋线;常规埋线组于2次体穴埋线后第2、8周予常规埋线。两组均干预8周（1个疗程）,12周后评定两组痤疮皮损疗效、痤疮皮损评分、伴随症状疗效、伴随症状评分及不良反应发生情况。结果　平滑线组痤疮皮损疗效、伴随症状疗效优于常规埋线组（P<0.05）。治疗前、后两组痤疮皮损、伴随症状评分比较,差异无统计学意义（P>0.05）。两组治疗后痤疮皮损、伴随症状评分均低于本组治疗前（P<0.05）。两组均未发生明显不良反应。结论　基于面部不同埋线方法的综合针灸疗法对女性青春期后痤疮皮损和伴随症状均有较好的临床疗效;面部埋线作用机制主要与经络、浅筋膜、卫气等理论密切相关;平滑线埋线较常规埋线患者痛苦小,且有较好的改善皱纹效果,因此平滑线埋线优于常规埋线,值得临床推广应用。     

南阳市大学生痤疮患病情况及影响因素研究

目的 了解南阳市大学生痤疮患病情况及影响因素,为痤疮的预防提供科学依据。方法 采用多级整群随机抽样方法,对南阳市大学生进行问卷调查,内容包括一般情况、痤疮患病情况及影响因素等。结果 痤疮总患病率为67.68%,其中男性患病率为66.90%,女性患病率为68.36%;单因素分析显示:痤疮与便秘[OR=2.901,95%CI(1.593,5.282)]、化妆品的使用[OR=1.676,95%CI(1.050,2.676)]、油性皮肤[OR=1.750,95%CI(1.311,2.335)]、阳性家族史[OR=1.502,95%CI(1.165,1.937)]、精神紧张[OR=2.362,95%CI(1.469,3.799)]、烟酒[OR=1.845,95%CI(1.321,2.575)]、喜食甜食[OR=1.346,95%CI(1.038,1.745)]或油腻食物[OR=1.389,95%CI(1.092,1.767)]有统计学意义(P≤0.05),logistic回归分析发现,便秘、油性皮肤、精神紧张、烟酒与痤疮有统计学意义。结论 痤疮是南阳市大学生的常见病,受多种因素影响,针对患病情况及影响因素,开展健康教育工作。     

Quality of life,self-esteem and psychosocial factors in adolescents with acne vulgaris

Background

Dermatological diseases, among which acne vulgaris, have psychological impact on the affected generating feelings of guilt, shame and social isolation.

Objectives

To compare quality of life, self-esteem and other psychosocial variables amongst adolescents with and without acne vulgaris, and between levels of severity.

Methods

Cross-sectional observational study in a sample of 355 high school students from the city of João Pessoa. Data collection was performed with questionnaires and clinical-dermatological evaluation. The primary variables were the incidence of AV; quality of life, set by the Children''s Dermatology Quality of Life Index and Dermatology Quality of Life Index; and self-esteem, measured by the Rosenberg Self-Esteem Scale. For calculation of statistical tests, we used the SPSS 20.0 software, considering p=0.05.

Results

The sample, with an average age of 16, showed 89.3% prevalence of acne vulgaris. The most prevalent psychosocial issue was "afraid that acne will never cease", present in 58% of affected youth. The median score of Quality of Life in Children''s Dermatology Index was different amongst students with and without acne vulgaris (p=0.003), as well as the Quality of Life in Dermatology (p=0.038) scores, so that students with acne vulgaris have worse QoL. There was a correlation between the severity of acne vulgaris and worse quality of life. Self-esteem was not significantly associated with the occurrence or severity of acne vulgaris.

Conclusions

acne vulgaris assumes significance in view of its high prevalence and the effect on quality of life of adolescents, more severe at the more pronounced stages of disease (p<0.001). The psychosocial impact of acne vulgaris should be valued in the management of patients with this condition.     

Personality Traits and Common Psychiatric Conditions in Adult Patients with Acne Vulgaris

Background

We believe that instances of neuroticism and common psychiatric disorders are higher in adults with acne vulgaris than the normal population.

Objective

Instances of acne in adults have been increasing in frequency in recent years. The aim of this study was to investigate personality traits and common psychiatric conditions in patients with adult acne vulgaris.

Methods

Patients who visited the dermatology outpatient clinic at Bozok University Medical School with a complaint of acne and who volunteered for this study were included. The Symptom Checklist 90-Revised (SCL 90-R) Global Symptom Index (GSI), somatization, depression, and anxiety subscales and the Eysenck Personality Questionnaire-Revised Short Form (EPQ-RSF) were administered to 40 patients who fulfilled the inclusion criteria before treatment. The results were compared with those of a control group.

Results

Of the 40 patients included in this study, 34 were female and 6 were male. The GSI and the somatization, depression, and anxiety subscales of the SCL 90-R were evaluated. Patients with adult acne had statistically significant higher scores than the control group on all of these subscales. In addition, patients with adult acne had statistically significantly higher scores on the neuroticism subscale of the EPQ-RSF.

Conclusion

Our results show that common psychiatric conditions are frequent in adult patients with acne. More importantly, neurotic personality characteristics are observed more frequently in these patients. These findings suggest that acne in adults is a disorder that has both medical and psychosomatic characteristics and requires a multi-disciplinary approach.     

针刺为主治疗难治性痤疮临床观察

目的观察针刺配合中药治疗难治性痤疮的疗效。方法收治180例难治性痤疮患者,以针药并用的方法施治。针刺取穴以局部近取与循经远取相结合,同时给予银翘四物汤口服治疗。结果 180例患者中,痊愈144例,显效21例,有效6例,无效9例,总有效率为95.0%。结论针刺配合中药是治疗难治性痤疮的有效方法。     

中西医结合治疗寻常痤疮疗效观察

目的：观察中西医结合治疗寻常痤疮的疗效。方法：80例符合入选标准的寻常痤疮患者随机分成两组,治疗组内服中药,每日2次,中药面膜外敷,每周3次,阿达帕林凝胶,每晚外用1次。对照组用阿达帕林凝胶治疗。所有治疗4周为1疗程,1疗程后观察疗效。结果：治疗组总有效率为92.5%,对照组总有效率为60%,两组疗效比较差异有显著性（P〈0.05）,两组均未发现明显不良反应。结论：中西医结合综合疗法治疗寻常痤疮疗效较好。