A rare cause of dysphagia： Herpes simplex esophagitis

Herpes simplex esophagitis (HSE) is well documented in immunosuppressed patients. However, it is rare in the immunocompetent host. We present a case of HSE in a 21 year-old healthy lady who was admitted to our unit with dysphagia, odynophagia and chest pain. Clinical examination revealed mild epigastric tenderness and admission bloods including full blood picture, electrolytes and in? ammatory markers were normal. She underwent an esophagogastroduodenoscopy (EGD) which revealed severe exudative, well-circumscribed ulcerations in her distal esophagus. Biopsies confi rmed severe esophagitis with acute ulceration and subsequent polymerase chain reaction (PCR) confirmed herpes simplex virus (HSV) type 1. Subsequent assessment failed to identify an immune disorder. HSE should be suspected when faced with characteristic endoscopic findings, even if the patient is immunocompetent. When the diagnosis of HSE is confi rmed, an immune defi ciency should be sought.     

浅谈硫糖铝悬液维持治疗反流性食道炎的疗效分析

目的 应用硫糖铝悬液对反流性食道炎进行维持治疗,以达到减少复发率,防止并发症发生的目的.方法 双盲选择60例患者,随机分为治疗组和比照组,治疗组给硫糖铝悬液口服.比照组给予安慰剂口服.结果 统计学检验两组复发率相比较存在著性差异.结论 硫糖铝悬液在反流性食道炎维持治疗中疗有显著疗效.     

心理护理联合丹栀逍遥散治疗老年性返流性食道炎120例

目的观察丹栀逍遥散联合心理护理治疗老年性反流性食道炎的临床疗效。方法选取2012年3月至2014年2月我院门诊的反流性食道炎患者180例,按随机数字表法（1：2）分为2组。对照组60例,采用奥美拉唑肠溶片,20mg,qd,po,晨起服;治疗组120例,在对照组基础上加用丹栀逍遥散及心理护理。2组均4周为1个疗程,疗程结束后对比。结果治疗组120例,痊愈67例,有效49例,无效4例,总有效率96.67%;对照组60例,痊愈28例,有效21例,无效11例,总有效率81.67%,两组比较,χ2=11.782,P=0.001,治疗组明显优于对照组。结论丹栀逍遥散联合心理护理治疗反流性食道炎临床疗效满意。     

药物性食道炎24例临床分析

目的探讨药物性食道炎临床特点,总结其诊断和治疗经验。方法回顾性分析我院收治的24例药物性食道炎的临床资料。结果 24例患者在内科保守治疗后痊愈。结论黏膜保护剂和抑酸剂是较好治疗措施。掌握正确的服药方法是预防药物性食道炎的关键。     

洛赛克及法莫替丁治疗耐H2—RA的反流性食道炎对比研究

目的：观察比较洛赛克又名奥咪拉唑（Omeprazole)和法莫替丁（Famotidine)对耐H2－受体拮抗剂（H2－RA）的返流性食道炎的疗效。方法：采用随机双盲法将病人分为洛赛克组及法莫替丁组，治疗8周，洛赛克及法莫替丁的剂量均为20mg，1日2次，治疗后的2，4，6，8周评价病人的症状并行胃镜检查，观察愈合率，结果：洛赛克在2，4，6，8周的愈合率分别为71％，80％，88％，及89％，而法莫替丁分别为21％，33％，45％及38％（每一时点P＜0．01），洛赛克对于烧心的缓解及抗酸药片的减量明显优于法莫替丁。结论：对于耐H2－RA的返流性食道炎病人，洛塞克比莫替丁更为有效。     

TAK-390MR

武田制药公司表示，其正处在研发阶段的一种质子泵抑制刺在治疗腐蚀性食道炎方面的效果优于同类畅销药Prevacid（1ansoprazole兰索拉唑）。     

霉菌性食道炎52例的临床分析

霉菌性食道炎系霉菌感染所致。霉菌是条件致病菌，如白色念珠菌广泛存在于自然界和人体内，在健康人群的机体内其系正常菌群。但由于各种原因导致机体免疫力低下的人群，霉菌会趁机侵入食道而致霉菌性食道炎。近年来，霉菌性食道炎发病率有所增加，而临床报道不多。现就我科自2002年1月～2004年l2月经胃镜检查诊断的52例霉菌性食道炎作临床分析。     

保留幽门间置空肠重建消化道20例体会

在胃癌病例中．仍有许多病例适宜选用全胃切除术。消化道重建方式目前有50余种，但无论保种手术，都是没有很好地解决术后反流及排空过快等问题，我科从2000年1月至2003年12月共收治胃底贲门癌患者采用保留幽门次全胃切除，间置空肠重建消化道手术，术后随访1年，没有1例发生反流性食道炎及倾倒综合征，疗效满意。现报告如下。     

Candida esophagitis： Risk factors in non-HIV population in Pakistan

AIM: Candida esophagitis is a trequent intection in immunocompromised patients. This study was designed to determine its characteristics in non- human immune deficiency virus (HIV) infected patients attending a teaching hospital. METHODS: Clinical records of all patients coded by international classification of diseases 9th revision with clinical modifications‘‘ (ICD-9-CM), with candida esophagitis diagnosed by esophagogastroduodenoscopy (EGD) and histopathology over a period of 5 years were studied.RESULTS: Fifty-one patients (27 males, 24 females, range 21-77 years old and mean age 52.9 years) fulfilled the criteria (0.34 % of the EGD). The common predisposing factorswere carcinoma (OR 3.87, CI 1.00-14.99) and diabetes mellitus (OR 4.39, CI 1.34-14.42). The frequent clinical symptoms were retrosternal discomfort, dysphagia and epigastric abdominal pain with endoscopic appearance of scattered mucosal plaques. Another endoscopic lesion was associated with candida esophagitis in 15 % patients.CONCLUSION: Carcinomas, diabetes mellitus, corticosteroid and antibiotic therapy are major risk factors for candida esophagitis in Pakistan. It is an easily managed complication that responds to treatment with nystatin.