全文获取类型
收费全文 | 6118篇 |
免费 | 310篇 |
国内免费 | 101篇 |
专业分类
耳鼻咽喉 | 180篇 |
儿科学 | 63篇 |
妇产科学 | 4篇 |
基础医学 | 731篇 |
口腔科学 | 45篇 |
临床医学 | 267篇 |
内科学 | 233篇 |
皮肤病学 | 8篇 |
神经病学 | 3586篇 |
特种医学 | 191篇 |
外科学 | 419篇 |
综合类 | 406篇 |
预防医学 | 47篇 |
眼科学 | 42篇 |
药学 | 227篇 |
中国医学 | 19篇 |
肿瘤学 | 61篇 |
出版年
2023年 | 60篇 |
2022年 | 72篇 |
2021年 | 117篇 |
2020年 | 137篇 |
2019年 | 133篇 |
2018年 | 160篇 |
2017年 | 144篇 |
2016年 | 184篇 |
2015年 | 154篇 |
2014年 | 284篇 |
2013年 | 325篇 |
2012年 | 307篇 |
2011年 | 353篇 |
2010年 | 304篇 |
2009年 | 340篇 |
2008年 | 363篇 |
2007年 | 320篇 |
2006年 | 323篇 |
2005年 | 268篇 |
2004年 | 217篇 |
2003年 | 183篇 |
2002年 | 172篇 |
2001年 | 144篇 |
2000年 | 135篇 |
1999年 | 129篇 |
1998年 | 127篇 |
1997年 | 132篇 |
1996年 | 104篇 |
1995年 | 103篇 |
1994年 | 78篇 |
1993年 | 71篇 |
1992年 | 54篇 |
1991年 | 64篇 |
1990年 | 45篇 |
1989年 | 45篇 |
1988年 | 39篇 |
1987年 | 36篇 |
1986年 | 42篇 |
1985年 | 45篇 |
1984年 | 28篇 |
1983年 | 26篇 |
1982年 | 27篇 |
1981年 | 19篇 |
1980年 | 23篇 |
1979年 | 15篇 |
1978年 | 16篇 |
1976年 | 13篇 |
1974年 | 7篇 |
1973年 | 10篇 |
1972年 | 9篇 |
排序方式: 共有6529条查询结果,搜索用时 15 毫秒
1.
《Gait & posture》2019
BackgroundRecent reports have shown that the daily cumulative moment in the frontal plane (i.e., product of hip moment impulse in the frontal plane during the stance phase and mean steps per day) is a risk factor for hip osteoarthritis. This study aimed to clarify the effect of contralateral cane use on hip moment impulse in the frontal plane of the stance limb.MethodsThis study included 15 healthy subjects who walked under four experimental conditions: (1) without a cane and (2–4) contralateral cane use with 10%, 15%, and 20% body weight support (BWS), respectively. To maintain the same walking speed in all conditions, the cadence was set to 80 steps/min, and the step length was fixed. The hip moment impulses in the frontal plane (i.e., area under the hip ab-adduction moment waveform) and peak hip adduction moments in all conditions were calculated.ResultsContralateral cane use significantly decreased the hip moment impulse in the frontal plane and peak hip adduction moment compared to non-cane use. Moreover, the hip moment impulse in the frontal plane and peak hip adduction moment decreased significantly with increased cane BWS. There were no significant differences in walking speed, cadence, and step length between the four conditions.ConclusionContralateral cane use decreases the hip moment impulse in the frontal plane and peak hip adduction moment in the stance limb. These findings may help clarify how to delay the progression of hip osteoarthritis. 相似文献
2.
Howard Morgan M.D. 《Surgical neurology》1990,33(6):413-416
The Russian writer Dostoevsky (1821–1881) suffered from a rare form of temporal lobe epilepsy termed “ec-static epilepsy.” Dostoevsky used his epileptic experiences to create Prince Myshkin, the protagonist of The Idiot. The recent case of a patient who experienced ecstatic epilepsy as a result of a temporal lobe brain tumor is presented and compared with that of Prince Myshkin. Reading Dostoevsky can give the contemporary physician an insight into the inner life of an epileptic patient — an example of how art can directly benefit medical practice. 相似文献
3.
4.
Paul C. Ivancic Manohar M. Panjabi Yasuhiro Tominaga Adam M. Pearson S. Elena Gimenez Travis G. Maak 《European spine journal》2006,15(6):891-901
Between 23 and 70% of occupants involved in frontal impacts sustain cervical spine injuries, many with neurological involvement. It has been hypothesized that cervical spinal cord compression and injury may explain the variable neurological profile described by frontal impact victims. The goals of the present study, using a biofidelic whole cervical spine model with muscle force replication, were to quantify canal pinch diameter (CPD) narrowing during frontal impact and to evaluate the potential for cord compression. The biofidelic model and a sled apparatus were used to simulate frontal impacts at 4, 6, 8, and 10 g horizontal accelerations of the T1 vertebra. The CPD was measured in the intact specimen in the neutral posture (neutral posture CPD), under static sagittal pure moments of 1.5 Nm (pre-impact CPD), during dynamic frontal impact (dynamic impact CPD), and again under static pure moments following each impact (post-impact CPD). Frontal impact caused significant (P<0.05) dynamic CPD narrowing at C0-dens, C2-C3, and C6-C7. The narrowest dynamic CPD was observed at C0-dens during the 10 g impact and was 25.9% narrower than the corresponding neutral posture CPD. Interpretation of the present results indicate that the neurological symptomatology reported by frontal impact victims is most likely not due to cervical spinal cord compression. Cord compression due to residual spinal instability is also not likely. 相似文献
5.
E S C Korf E C W van Straaten F-E de Leeuw W M van der Flier F Barkhof L Pantoni A M Basile D Inzitari T Erkinjuntti L-O Wahlund E Rostrup R Schmidt F Fazekas P Scheltens 《Diabetic medicine》2007,24(2):166-171
HYPOTHESIS: Based on recent findings on the association between vascular risk factors and hippocampal atrophy, we hypothesized that hypertension and diabetes mellitus (DM) are associated with medial temporal lobe atrophy (MTA) in subjects without disability, independent of the severity of white matter hyperintensities. METHODS: In the Leukoaraiosis And DISability in the elderly (LADIS) study, we investigated the relationships between DM, hypertension, blood pressure and MTA in 582 subjects, stratified by white matter hyperintensity severity, using multinomial logistic regression. MTA was visually scored for the left and right medial temporal lobe (score 0-4), and meaned. RESULTS: Mean age was 73.5 years (sd 5.1), 54% was female. Of the subjects, 15% had DM, and 70% had a history of hypertension. The likelihood of having MTA score 3 was significantly higher in subjects with DM (OR 2.9; 95% CI: 1.1-7.8) compared with an MTA score of 0 (no atrophy). The odds ratio for MTA score 2 was not significantly increased (OR 1.8; CI: 0.9-4). Systolic and diastolic blood pressure and a history of hypertension were not associated with MTA. There was no interaction between DM and hypertension. Stratification on white matter hyperintensities (WMH) did not alter the associations. CONCLUSION: Our study strengthens the observation that MTA is associated with DM, independently of the amount of small vessel disease as reflected by WMH. 相似文献
6.
7.
Patrick E. Barta Richard E. Powers Elizabeth H. Aylward Gary A. Chase Gordon J. Harris Peter V. Rabins Larry E. Tune Godfrey D. Pearlson 《Psychiatry Research: Neuroimaging》1997,68(2-3):65-75
Volumes of medial and lateral temporal lobe structures were assessed using magnetic resonance imaging (MRI) in 11 patients with late-life onset schizophrenia (LOS), 18 normal elderly controls and 12 patients with moderate cognitive impairment due to Alzheimer's disease (AD) who had no non-cognitive symptoms. While both patient groups has smaller volumes of several medial temporal regions (e.g. entorhinal cortex, left hippocampus), schizophrenics had significantly smaller anterior superior temporal gyri (STG) than normal controls, but AD patients did not. We have previously demonstrated anterior STG volume to be reduced in early life onset schizophrenia. 相似文献
8.
The role of several hippocampal innervations in the sensitivity to barbital-induced narcosis was studied in selected mice strains. The outbred and inbred mouse strains HS/Ibg, SABRA/HUC, C57BL, CBA/LAC, and BALB/c were tested for barbital-induced sleep (315 mg/kg). The relatively short sleeping HS/Ibg (HS) and the longest sleeping BALE/c (BALE) were chosen for further investigation. Cholinergic (ACh), serotonergic (5-HT), and noradrenergic (NE) innervations were studied in HS strain; whereas BALE, which possesses both an unusually high sensitivity to barbital and unique NE innervations in the cortex and hippocampus, was employed in a detailed study of the NE innervations. Transplantation of embryonic NE cells from the mouse embryo into the hippocampus of adult HS mice increased barbital narcosis by 65% (p < 0.05), whereas transplantation of 5-HT cells decreased barbital narcosis by 54% (p < 0.001). Transplantation of ACh cells had no significant effect on barbital-induced narcosis. BALB mice were subjected to NE cell transplantation into the hippocampus and cortex. Similarly to HS, BALB receiving NE transplants into their hippocampus slept 34% longer than control after barbital challenge (p < 0.025). Noradrenergic cell transplantation into frontal cortex had no effect on barbital sleep. The results suggest that (a) enhancement by neural grafting of the NE innervation to the hippocampus accentuates and enhancement of the 5-HT innervations attenuates the sensitivity to barbital narcosis, whereas ACh innervations have no effect on the sensitivity to barbital narcosis, and (b) the unusually high sensitivity of BALB mice to barbital may not be related to its unique NE innervations. 相似文献
9.
S. Lehéricy F. Semah D. Hasboun D. Dormont S. Clémenceau O. Granat C. Marsault M. Baulac 《Neuroradiology》1997,39(11):788-796
MRI was performed in 222 consecutive adult patients with temporal lobe epilepsy of varying severity from January 1991 to
May 1993. The diagnosis of hippocampal sclerosis was established visually by three independent observers. The accuracy of
visual assessment of hippocampal asymmetry was compared with volumetric measurements. Neuropathological correlations were
obtained in 63 patients with refractory seizures. Temporal lobe abnormalities were observed in 180 patients (81 %) as follows:
hippocampal sclerosis in 122 (55 %); developmental abnormalities in 16 (7.2 %); tumours in 15 (6.8 %); scars in 11 (5 %);
cavernous angiomas in 10 (4.5 %); miscellaneous lesions in 6. MRI was normal or showed unrelated changes in 42 patients (19
%). Visual assessment correctly lateralised hippocampal sclerosis in 79 of the 84 patients measured (94 %). Temporal lobectomy
confirmed the MRI data (side and aetiology) in all 63 operated patients. Patients with normal MRI had an older age of seizure
onset and were more often drug-responsive than patients with hippocampal sclerosis. MRI showed temporal lobe abnormalities
in 81 % of epileptic patients with varying severity with good neuropathological correlation. Patients with normal MRI had
a less severe form of the disease.
Received: 19 August 1996 Accepted: 13 November 1996 相似文献
10.
Kuo-Sheng Hung MD Phd Chung-Ling Liang MD Cheng-Haung Wang MD Hsueh-Wen Chang PhD Naeun Park MS Suh-Hang Hank Juo MD PhD 《Journal of clinical neuroscience》2004,11(8):849-853
Frontal intracerebral haemorrhage (ICH) is a common result of cranial trauma. Outcome differences between bilateral and unilateral frontal ICH are not well studied but would be valuable to predict prognosis in clinical practice. Two aims are proposed in this study: first to compare the risk of developing delayed ICH after bilateral or unilateral frontal ICH, and second to determine the variables helpful to predict outcome according to the Glasgow Outcome Scale (GOS). Between January 1993 and December 1997, 694 consecutive patients with traumatic ICH were admitted to the Chang Gung Medical Center within 24 h of the trauma. Patients with ICH in sites other than the frontal lobes were excluded. A total of 161 cases (mean age 46.3+/-20.3 years), including 57 bilateral (mean age 52.5+/-18.7 years) and 104 unilateral (mean age 42.9+/-20.5 years) traumatic frontal ICH were studied. Twenty-eight of 57 patients (49%) with bifrontal ICH versus 17 of 104 patients (16%) with unilateral frontal ICH had a further, delayed ICH. In 42 of 45 patients (93%) with delayed ICH, this occurred within 5 days of the initial trauma. Multivariate logistic regression was used to select significant predictors of outcome. We found that delayed ICH (p<0.001), age (p=0.004) and mechanism of injury (p=0.001) explained the worse outcome in patients with bifrontal ICH. The best-fitting logistic regression model included three variables: delayed ICH (p=0.011), initial GCS (p=0.023), and a sum score of clinical and radiological variables (p=0.003). Bifrontal ICH tended to occur in older patients after a fall and was associated with a higher risk of developing delayed ICH or brain stem compression compared to unilateral ICH damage. Using these three variables - delayed ICH, initial GCS, and the sum score - in a logistical regression model is useful to predict outcome in patients with traumatic frontal ICH and may aid patient management. 相似文献