应用冠状切口治疗颧弓、颧骨骨折38例临床分析

目的　对于我科应用冠状切口治疗 38例颧弓、颧骨骨折行综合临床分析。方法　收集经冠状切口治疗的颧弓、颧骨骨折患者 38例 ,对其临床资料进行分析研究。结果　依治疗后功能恢复情况、面部畸形整复效果及并发症消失程度分级 ,38例中效果优级 2 6例 ,占 6 8.4% ,良级 1 2例 ,占 31 .6 %。结论　应用冠状切口行手术治疗较其它术式可获更为理想的治疗效果。     

严重晶状体不全脱位的小切口囊袋内吸出术

目的评价自闭性小切口囊袋内吸出术治疗严重晶状体不全脱位的疗效。方法对１４例１８眼悬韧带离断大于１８０°的严重晶状体不全脱位者,根据晶状体核硬度的不同,分别采用自闭性小切口手动囊袋内吸出术和超声乳化囊袋内吸出术。结果术后随访３月～２年,２例４眼因弱视矫正视力０１～０３,３例５眼０５～０７,８例外伤眼术中植入人工晶状体,７例裸眼视力０５～１０,另１眼因青光眼视神经损害视力００３。无术中及术后并发症。结论此手术方法具有切口小,对角膜、虹膜及玻璃体扰动小,便于联合其它手术,术中、术后并发症少,视力恢复好等优点,是一种安全、有效的手术方法。     

高龄老年白内障透明角膜切口超声乳化术临床探讨

目的 探讨避免高龄老年白内障手术风险的办法。方法 对高龄老年白内障３６眼采用透明角膜切口和机械碎核协助进行超声乳化手术。结果 术中血压平稳,眼心反射不明显,安全手术。术后１月视力〉０．５占８６．１１％。结论采用透明角膜切口避免球后麻醉和压迫眼球并缩短术程,能减少风险;机械碎核可降低超声能量,减少角膜并发症,提高疗效。     

放射状角膜切开手术中微穿孔对角膜内皮的影响

目的：评价放射状角膜切开术（ＲＫ）中微穿孔对术后１年内角膜内皮的影响。方法：应用角膜内皮镜及角膜内皮分析仪研究４８例ＲＫ术中微穿孔和未穿孔眼的角膜内皮形态学变化,分别在术前及术后１、３、６、１２个月行角膜内皮检查及分析。结果：比较手术前后角膜内皮的数量、平均面积、最大面积和最小面积,穿孔眼及未穿孔眼差异无显著性,但内皮细胞面积两组都有扩大的趋势。结论：ＲＫ术后一年内无论微穿孔还是未穿孔眼的角膜内皮     

Binding of psychotropic drugs to isolated alpha-acid glycoprotein

Alpha1-acid glycoprotein (alpha1-AG) was purified from human sera, and its binding properties with respect to psychotropic drugs were examined by equilibrium dialysis methods in order to clarify the specificity of binding. Radioactive imipramine, a tricyclic antidepressant, was used as the primary ligand. Other drugs, representative of different classes, were tested as potential inhibitors of the alpha1-AG-imipramine binding. The K(a) for imipramine was 2.8 x 10(5) (+/- 0.8) M(-10 (mean +/- S.D.). Chlorpromazine, fluphenazine, thioridazine, loxapine and thiothixene, which are antipsychotic drugs, were competitive inhibitors of imipramine binding, and their K(a) values were in the same range. Propranolol, haloperidol and diazepam were also competitive inhibitors but their affinities were lower. Molindone, an indolic antipsychotic, when tested at the same concentrations as the other drugs, did not affect imipramine binding. Trihexyphenidyl, an anti-Parkinson drug, was a potent but noncompetitive inhibitor. These data identify the antidepressant and major tranquilizer drugs that exhibit high affinity for alpha1-AG and indicate that alpha1-AG may account for 40 per cent of total imipramine bound in serum. Since in psychiatric clinical practice two drugs are frequently administered together, possible competitive effects are discussed as well as the potential role of alpha1-AG in psychiatric illness.     

Combined lesions of cholinergic and serotonergic neurons in the rat brain using 192 IgG-saporin and 5,7-dihydroxytryptamine: neurochemical and behavioural characterization

This study assessed behavioural and neurochemical effects of i.c.v. injections of both the cholinergic toxin 192 IgG-saporin (2 microgram) and the serotonergic toxin 5,7-dihydroxytryptamine (5,7-DHT; 150 microgram) in Long-Evans female rats. Dependent behavioural variables were locomotor activity, forced T-maze alternation, beam walking, Morris water-maze (working and reference memory) and radial-maze performances. After killing by microwave irradiation, the concentrations of acetylcholine, monoamines and 5-hydroxyindoleacetic acid (5-HIAA) were measured in the hippocampus, frontoparietal cortex and striatum. 192 IgG-saporin reduced the concentration of acetylcholine by approximately 40% in the frontoparietal cortex and hippocampus, but had no effect in the striatum. 5,7-DHT lesions reduced the concentration of serotonin by 60% in the frontoparietal cortex and 80% in the hippocampus and striatum. Noradrenaline was unchanged in all structures except the ventral hippocampus where it was slightly increased in rats given 192 IgG-saporin. Cholinergic lesions induced severe motor deficits but had no other effect. Serotonergic lesions produced diurnal and nocturnal hyperactivity but had no other effect. Rats with combined lesions were more active than those with only serotonergic lesions, showed motor dysfunctions similar to those found in rats with cholinergic lesions alone, and exhibited impaired performances in the T-maze alternation test, the water-maze working memory test and the radial-maze. Taken together and although cholinergic lesions were not maximal, these data show that 192 IgG-saporin and 5,7-DHT lesions can be combined to selectively damage cholinergic and serotonergic neurons, and confirm that cholinergic-serotonergic interactions play an important role in some aspects of memory, particularly in spatial working memory.     

小切口白内障手术中后囊膜破裂一期人工晶体植入术临床疗效分析

目的评价小切口白内障摘除术术中后囊膜破裂的原因及处理方法.方法回顾分析1 05 6例小切口白内障手术联合人工晶体植入术,其中术中51例后囊膜破裂,玻璃体溢出,行前段玻璃体切割术联合一期后房型人工晶体植入术.结果本组患者手术中后囊膜破裂发生率为4.8%,全部行一期后房型人工晶体植入术,其中5例囊袋内固定植入,42例睫状沟固定植入和4例DGR人工晶体双襻缝线固定法植入.术后矫正视力大于或等于0.3者46例(90.2%);矫正视力大于或等于0.05,低于0.3者4例(7.8%);矫正视力低于0.05者1例(2.0%).结论前段玻璃体切割术为小切口白内障摘除术中后囊膜破裂一期人工晶体植入提供了安全有效的保证.     

Peritonsillar abscess – critical analysis of abscess tonsillectomy

The risk of secondary haemorrhage following abscess tonsillectomy is reported in the literature with differing rates. A retro‐ and prospective analysis of complication rates following abscess tonsillectomy was conducted in 142 patients (54 females, 88 males; mean age: 35 years). In 22% of patients, a secondary haemorrhage occurred. In half of these (11% of total), the haemorrhage had to be treated surgically. Secondary haemorrhage occurred most commonly on the 6th and 8th postoperative days. Reports in the literature are not in unison about the risk of secondary haemorrhage following abscess tonsillectomy and therefore allow no final judgement about an objective risk of this complication. This report strengthens the results of the ‘Comparative Audit Service’ analysis from 1997, which did show a high risk of secondary haemorrhage following tonsillectomy, as well as following abscess tonsillectomy.     

子宫下段高位剖宫产与新式剖宫产临床对照分析

目的　评价子宫下段高位剖宫产与新式剖宫产两种术式的优缺点。方法　 2 0 0例行子宫下段高位剖宫产 ,另 2 0 0例行新式剖宫产。观察手术时间、出血量、娩头困难例数、子宫切口撕裂例数、新生儿Ap gar评分等 ,并进行比较分析。 结果　子宫下段高位剖宫产平均出血量为 138 85± 5 3 74ml,明显低于新式剖宫产平均出血量 190 5± 5 9 18ml,差异有非常显著意义 (P <0 0 1)。两种术式的手术时间、娩头困难例数、子宫切口撕裂例数、新生儿Apgar评分经统计学处理 ,差异均无显著意义 (P >0 0 5 )。 结论　子宫下段高位剖宫产术中出血量少 ,优于新式剖宫产 ,可在临床推广应用。     

祛腐生肌散治疗难愈性切口感染临床观察

目的　观察中药祛腐生肌散治疗难愈性切口感染的效果。方法　选用蜈蚣、冰片等 5味中药研末制成散剂 ,换药时撒薄层于无菌凡士林油纱布上 ,敷或塞于伤口。结果　 1个月内治愈 18例 ,2个月内治愈 10例 ,3个月内治愈 8例 ,无效 1例。结论　中药祛腐生肌散具有活血止痛、祛腐生肌之功效 ,治疗难愈性切口感染疗效显著。