收费全文 | 3374篇 |
免费 | 223篇 |
国内免费 | 60篇 |
耳鼻咽喉 | 75篇 |
儿科学 | 13篇 |
妇产科学 | 14篇 |
基础医学 | 530篇 |
口腔科学 | 54篇 |
临床医学 | 156篇 |
内科学 | 133篇 |
皮肤病学 | 5篇 |
神经病学 | 1288篇 |
特种医学 | 99篇 |
外科学 | 629篇 |
综合类 | 226篇 |
预防医学 | 33篇 |
眼科学 | 244篇 |
药学 | 105篇 |
2篇 | |
中国医学 | 22篇 |
肿瘤学 | 29篇 |
2024年 | 8篇 |
2023年 | 43篇 |
2022年 | 60篇 |
2021年 | 116篇 |
2020年 | 111篇 |
2019年 | 121篇 |
2018年 | 128篇 |
2017年 | 118篇 |
2016年 | 87篇 |
2015年 | 105篇 |
2014年 | 183篇 |
2013年 | 191篇 |
2012年 | 196篇 |
2011年 | 191篇 |
2010年 | 147篇 |
2009年 | 162篇 |
2008年 | 172篇 |
2007年 | 154篇 |
2006年 | 156篇 |
2005年 | 114篇 |
2004年 | 86篇 |
2003年 | 78篇 |
2002年 | 63篇 |
2001年 | 53篇 |
2000年 | 38篇 |
1999年 | 50篇 |
1998年 | 45篇 |
1997年 | 46篇 |
1996年 | 41篇 |
1995年 | 37篇 |
1994年 | 28篇 |
1993年 | 18篇 |
1992年 | 24篇 |
1991年 | 27篇 |
1990年 | 28篇 |
1989年 | 18篇 |
1988年 | 23篇 |
1987年 | 19篇 |
1986年 | 33篇 |
1985年 | 57篇 |
1984年 | 66篇 |
1983年 | 63篇 |
1982年 | 31篇 |
1981年 | 43篇 |
1980年 | 33篇 |
1979年 | 17篇 |
1978年 | 14篇 |
1977年 | 5篇 |
1976年 | 5篇 |
1975年 | 3篇 |
Background:
Major depressive disorder has been associated with abnormal resting-state functional connectivity (FC), especially in cognitive processing and emotional regulation networks. Although studies have found abnormal FC in regions of the default mode network (DMN), no study has investigated the FC of specific regions within the anterior DMN based on cytoarchitectonic subdivisions of the antero-medial pre-frontal cortex (PFC). Studies from different areas in the field have shown regions within the anterior DMN to be involved in emotional intelligence. Although abnormalities in this region have been observed in depression, the relationship between the ventromedial PFC (vmPFC) function and emotional intelligence has yet to be investigated in depressed individuals.Methods:
Twenty-one medication-free, non–treatment resistant, depressed patients and 21 healthy controls underwent a resting state functional magnetic resonance imaging session. The participants also completed an ability-based measure of emotional intelligence: the Mayer-Salovey-Caruso Emotional Intelligence Test. FC maps of Brodmann areas (BA) 25, 10m, 10r, and 10p were created and compared between the two groups.Results:
Mixed-effects analyses showed that the more anterior seeds encompassed larger areas of the DMN. Compared to healthy controls, depressed patients had significantly lower connectivity between BA10p and the right insula and between BA25 and the perigenual anterior cingulate cortex. Exploratory analyses showed an association between vmPFC connectivity and emotional intelligence.Conclusions:
These results suggest that individuals with depression have reduced FC between antero-medial PFC regions and regions involved in emotional regulation compared to control subjects. Moreover, vmPFC functional connectivity appears linked to emotional intelligence. 相似文献Objective
To investigate the relation between lower limb muscle strength, passive muscle properties, and functional capacity outcomes in adults with cerebral palsy (CP).Design
Cross-sectional study.Setting
Tertiary institution biomechanics laboratory.Participants
Adults with spastic-type CP (N=33; mean age, 25y; range, 15–51y; mean body mass, 70.15±21.35kg) who were either Gross Motor Function Classification System (GMFCS) level I (n=20) or level II (n=13).Interventions
Not applicable.Main Outcome Measures
Six-minute walk test (6MWT) distance (m), lateral step-up (LSU) test performance (total repetitions), timed up-stairs (TUS) performance (s), maximum voluntary isometric strength of plantar flexors (PF) and dorsiflexors (DF) (Nm.kg?1), and passive ankle joint and muscle stiffness.Results
Maximum isometric PF strength independently explained 61% of variance in 6MWT performance, 57% of variance in LSU test performance, and 50% of variance in TUS test performance. GMFCS level was significantly and independently related to all 3 functional capacity outcomes, and age was retained as a significant independent predictor of LSU and TUS test performance. Passive medial gastrocnemius muscle fascicle stiffness and ankle joint stiffness were not significantly related to functional capacity measures in any of the multiple regression models.Conclusions
Low isometric PF strength was the most important independent variable related to distance walked on the 6MWT, fewer repetitions on the LSU test, and slower TUS test performance. These findings suggest lower isometric muscle strength contributes to the decline in functional capacity in adults with CP. 相似文献Objectives
To compare the effects of conventional core stabilization and dynamic neuromuscular stabilization (DNS) on anticipatory postural adjustment (APA) time, balance performance, and fear of falls in chronic hemiparetic stroke.Design
Two-group randomized controlled trial with pretest-posttest design.Setting
Hospital rehabilitation center.Participants
Adults with chronic hemiparetic stroke (N=28).Interventions
Participants were randomly divided into either conventional core stabilization (n=14) or DNS (n=14) groups. Both groups received a total of 20 sessions of conventional core stabilization or DNS training for 30 minutes per session 5 times a week during the 4-week period.Main Outcome Measures
Electromyography was used to measure the APA time for bilateral external oblique (EO), transverse abdominis (TrA)/internal oblique (IO), and erector spinae (ES) activation during rapid shoulder flexion. Trunk Impairment Scale (TIS), Berg Balance Scale (BBS), and Falls Efficacy Scale (FES) were used to measure trunk movement control, balance performance, and fear of falling.Results
Baseline APA times were delayed and fear of falling was moderately high in both the conventional core stabilization and DNS groups. After the interventions, the APA times for EO, TrA/IO, and ES were shorter in the DNS group than in the conventional core stabilization group (P<.008). The BBS and TIS scores (P<.008) and the FES score (P<.003) were improved compared with baseline in both groups, but FES remained stable through the 2-year follow-up period only in the DNS group (P<.003).Conclusions
This is the first clinical evidence highlighting the importance of core stabilization exercises for improving APA control, balance, and fear of falls in individuals with hemiparetic stroke. 相似文献Design: Retrospective case series.
Material and Methods: In this retrospective case series, we present 2 patients (3 eyes) with Type C dural CCFs, who had failed cannulation via the conventional transfemoral route and the transorbital superior ophthalmic vein approach. They subsequently underwent CCF occlusion via an anterior orbital approach through the medial ophthalmic veins, at the Department of Ophthalmology, National University Hospital Singapore. CCF occlusion was confirmed intraoperatively using angiography. Both patients were evaluated postoperatively for best-corrected visual acuity and resolution of clinical signs and symptoms.
Results: Successful occlusion of CCFs via the medial ophthalmic veins were achieved in all three orbits, with excellent visual and cosmetic outcomes postoperatively.
Conclusion: Dural CCFs may potentially lead to severe visual dysfunction and should be diagnosed and treated promptly. When all venous routes have been exhausted, the transorbital approach via the medial ophthalmic vein remains an excellent and viable alternative to access the fistula. Close cooperation between the orbital, anesthetic and radiological teams is essential in ensuring success of the operation. 相似文献
![点击此处可从《Clinical and experimental pharmacology & physiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)