收费全文 | 33966篇 |
免费 | 4292篇 |
国内免费 | 415篇 |
耳鼻咽喉 | 571篇 |
儿科学 | 6488篇 |
妇产科学 | 235篇 |
基础医学 | 2654篇 |
口腔科学 | 1083篇 |
临床医学 | 3776篇 |
内科学 | 3299篇 |
皮肤病学 | 424篇 |
神经病学 | 1660篇 |
特种医学 | 487篇 |
外科学 | 1870篇 |
综合类 | 3809篇 |
现状与发展 | 2篇 |
一般理论 | 2篇 |
预防医学 | 7446篇 |
眼科学 | 970篇 |
药学 | 2537篇 |
35篇 | |
中国医学 | 771篇 |
肿瘤学 | 554篇 |
2024年 | 116篇 |
2023年 | 672篇 |
2022年 | 1103篇 |
2021年 | 1596篇 |
2020年 | 1621篇 |
2019年 | 1347篇 |
2018年 | 1203篇 |
2017年 | 1420篇 |
2016年 | 1565篇 |
2015年 | 1304篇 |
2014年 | 2138篇 |
2013年 | 3015篇 |
2012年 | 2024篇 |
2011年 | 2155篇 |
2010年 | 1776篇 |
2009年 | 1580篇 |
2008年 | 1512篇 |
2007年 | 1620篇 |
2006年 | 1429篇 |
2005年 | 1289篇 |
2004年 | 1078篇 |
2003年 | 864篇 |
2002年 | 790篇 |
2001年 | 674篇 |
2000年 | 513篇 |
1999年 | 435篇 |
1998年 | 484篇 |
1997年 | 423篇 |
1996年 | 372篇 |
1995年 | 290篇 |
1994年 | 295篇 |
1993年 | 233篇 |
1992年 | 177篇 |
1991年 | 180篇 |
1990年 | 161篇 |
1989年 | 156篇 |
1988年 | 130篇 |
1987年 | 98篇 |
1986年 | 130篇 |
1985年 | 97篇 |
1984年 | 74篇 |
1983年 | 72篇 |
1982年 | 57篇 |
1981年 | 56篇 |
1980年 | 55篇 |
1979年 | 48篇 |
1978年 | 36篇 |
1977年 | 33篇 |
1976年 | 53篇 |
1973年 | 24篇 |
![点击此处可从《Clinical and experimental pharmacology & physiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Aims
A systematic review of the literature published in English over 10 years was undertaken in order to describe the use of electronic healthcare data in the identification of potential adverse drug reactions (ADRs) in children.Methods
MEDLINE and EMBASE were searched using MESH headings and text words. Titles, keywords and abstracts were checked for age <18 years, potential ADRs and electronic healthcare data. Information extracted included age, data source, pharmacovigilance method, medicines and ADRs. Studies were quality assessed.Results
From 14 804 titles, 314 had a full text review and 71 were included in the final review. Fifty were published in North America, 10 in Scandinavia. Study size ranged from less than 1000 children to more than 10 million. Sixty per cent of studies used data from one source. Comparative observational studies were most commonly reported (66.2%) with 15% using passive surveillance. Electronic healthcare data set linkage and the quality of the data source were poorly reported. ADRs were classified using the International Classification of Disease (ICD10). Multi-system reactions were most commonly studied, followed by central nervous system and mental and behavioural disorders. Vaccines were most frequently prescribed followed by corticosteroids, general anaesthetics and antidepressants.Conclusions
Routine electronic healthcare records were increasingly reported to be used for pharmacovigilance in children. This growing and important health protection activity could be enhanced by consistent reporting of studies to improve the identification, interpretation and generalizability of the evidence base. 相似文献Objectives
To investigate the association of serum lipids and high-sensitivity C-reactive protein (hs-CRP) with obesity in school children and to explore whether hs-CRP levels could be used to predict the presence or absence of obesity 12 months later.Methods
The subjects were school children (6–11 years old) in Japan. Blood sampling and physical measurements were performed in school (2001); low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and hs-CRP levels were measured. Data from children who could be followed 12 months later were analyzed. Subjects weighing 20 % or more over his/her standard weight were regarded as obese, and the association of obesity with serum parameters was analyzed.Results
Data from 612 subjects were analyzed (follow-up rate, 75.4 %). The mean of each serum parameter was significantly higher (inverse for HDL-C; lower) in obese than that in non-obese children. Logistic regression analysis for obesity at baseline showed that the odds ratio (OR) of hs-CRP was the highest [OR, 2.15; 95 % confidence interval (CI), 1.65–2.78 for an interquartile rage (IQR) increase]; the association with triglycerides and LDL-C/HDL-C was significant. At the 12-month follow-up, the OR of high hs-CRP remained the highest of all serum parameters (2.09; 95 % CI, 1.63–2.69 for an IQR increase).Conclusions
High levels of triglycerides, LDL-C/HDL-C, and hs-CRP increased the risk of obesity in school children. Hs-CRP is considered to be a better predictor of obesity 12 months later than is LDL-C/HDL-C. 相似文献Design. Eight months of ethnographic field studies were conducted among four ethnic minority groups living in highland and lowland communities in northern Vietnam. Data included participant observation in four kindergartens and 20 homes of pre-school children, together with 67 semi-structured interviews with caregivers and five kindergarten staff. Thematic analysis was applied and concepts of social learning provided inputs to the analysis.
Findings. This study showed that poor living conditions with lack of basic sanitation infrastructures were important barriers for the implementation of safe home child hygiene. Furthermore, the everyday life of highland villages, with parents working away from the households resulted in little daily adult supervision of safe child hygiene practices. While kindergartens were identified as potentially important institutions for improving child hygiene education, essential and well-functioning hygiene infrastructures were lacking. Also, hygiene teaching relied on theoretical and non-practice-based learning styles, which did not facilitate hygiene behaviour change in small children. Minority children were further disadvantaged as teaching was only provided in non-minority language.
Conclusions. Kindergartens can be important institutions for the promotion of safe hygiene practices among children, but they must invest in the maintenance of hygiene and sanitation infrastructures and adopt a strong practice-based teaching approach in daily work and in teacher's education. To support highland minority children in particular, teaching styles must take local living conditions and caregiver structures into account and teach in local languages. Creating stronger links between home and institutional learning environments can be vital to support disadvantaged highland families in improving child health. 相似文献