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91.
Israel Shapiro Zvi Borochowitz Shimon Degani Hanna Dar Izu Ibschitz Mordechai Sharf 《American journal of medical genetics. Part A》1992,43(3):602-605
A diagnosis of the Neu-Laxova syndrome (NLS) was made by ultrasonography at 32 wks of gestation. Ultrasonographic examination showed intrauterine growth retardation (IUGR), Dandy-Walker anomaly, choroid plexus cysts, receding forehead and microcephaly, bilateral cataract without prominent eyes, scalp edema with no generalized edema, retrognathia, curved penis, and flexion deformities of limbs. The findings in this case are consistent with NLS; however, they did not fit any of Curry's [1982] groups. Massive swelling of hands and feet were among the main manifestations in classic NLS cases. In the case presented herein, edema was noted only in the scalp. This might shed further light on the question of variability vs. heterogeneity in the NLS. This case shows the existing possibility of an early diagnosis of NLS and adds Dandy-Walker anomaly and choroid plexus cysts as new findings to this syndrome. © 1992 Wiley-Liss, Inc. 相似文献
92.
基于自适应小波神经网络的心电图检测法 总被引:2,自引:0,他引:2
自适应小波神经网络检测法就是利用小波函数取代通常神经网络中隐层的作用函数来实现的,通过网络的学习自适应地调整尺度参数和时移因子,提高了特征提取能力,因此,该网络可提高心电信号的检测率和可靠性。 相似文献
93.
Visualizing metabolic changes in breast-cancer tissue using 1H-NMR spectroscopy and self-organizing maps 总被引:8,自引:0,他引:8
In-vitro NMR spectroscopic examinations of tissue extracts can be combined with appropriate pattern-recognition and visualization techniques in order to monitor characteristic metabolic differences between tissue classes. In the present study, such techniques are applied to a set of 88 breast-tissue samples with the intention of identifying typical differences between various tissue classes. The set contains 49 breast-tumor samples of various tumor grades and 39 samples of healthy tissue. The metabolite compositions of the tissue extracts were investigated using a dual extraction technique and high-resolution (1)H-NMR spectroscopy. The spectra of the hydrophilic and the lipophilic compounds were assigned to three groups according to different malignancy grades of the respective tissue samples. The group characteristics were analyzed using the k-nearest-neighbor method and self-organizing-map visualizations. The results show an increase of UDP-hexose, phosphocholine and phosphoethanolamine concentrations according to the tumor grade. Higher concentrations of taurine were detected in the malignant samples. Myo-inositol and glucose content were elevated in control samples compared with malignant tissue. Both compounds also characterized different subgroups in the pool of unaffected tissue samples depending upon fat content or fibrosis. Several lipid metabolites showed a characteristic elevation with high malignancy. 相似文献
94.
基于经验模式分解的心电特征提取算法 总被引:1,自引:0,他引:1
本研究应用基于经验模式分解的心电特征提取方法,利用第一本征模函数(intrinsic mode function,IMF)分量对QRS波进行定位,并通过减少分解层数、筛选次数、处理区域等策略实现了快速算法。利用MIT-BIT心律失常数据库的数据进行算法测试,取得较高的检测率,检测速度也有明显提高。实验结果表明,经验模式分解算法在QRS波定位中具有相当的优越性,临床应用中取得了良好的检测效果。 相似文献
95.
96.
中国东北汉族一个先天性白内障家系致病基因的鉴定 总被引:5,自引:0,他引:5
目的鉴定一个先天性白内障家系的致病基因。方法根据已知与先天性白内障有关的12个致病基因的染色体上的定位,分别选取3~4个的微卫星标记位点,对该家系进行连锁分析。通过测序鉴定致病基因。结果在1q21.1GJA8位点显示最大Lod值2.44。致病基因定位于1q21.1区的GJA8基因,构成缝隙连接的缝隙连接蛋白Connexin50。DNA序列分析鉴定显示其第2外显子的第191个碱基杂合突变T>G导致其蛋白产物第64位缬氨酸转变为甘氨酸。结论Connexin50的V64G新生突变是导致该家系的致病原因。 相似文献
97.
RNA was extracted from tissues processed by a new fixation and paraffin-embedding method (the AMeX method) and examined by Northern blot analysis and slot-blot analysis. The RNA extraction method for AMeX-processed tissue sections after the deparaffinization step was the same as that for fresh materials. The total amount of cellular RNA extracted from AMeX-processed mouse liver tissue was slightly less than that extracted from fresh tissue. In tissues of malignant lymphoma, the total amount of cellular RNA extracted from 25 sections each 20 microns thick was about 1.6-1.8 micrograms/mm2, regardless of the histological subtype and period of storage. The extracted RNA was moderately degraded, and usually could not be used for Northern blot hybridization analysis. The intensity of ethidium bromide staining and the hybridization signals of RNA extracted from AMeX-processed tissues were usually reduced in comparison with RNA from fresh material, but specific signals could be detected by slot-blot hybridization analysis. We have demonstrated previously that the AMeX method preserves high-molecular-weight DNA and various antigens. Since the present study showed that information on mRNA can be obtained from AMeX-processed tissue, the versatility and usefulness of this method were further proven. 相似文献
98.
Pietro Cavalli Daniela Giardino Giulietta Gottardi Federica Natacci Salvatore Savasta Lidia Larizza 《American journal of medical genetics. Part A》2001,104(2):157-164
We describe the case of a 15‐year‐old girl with multiple congenital anomalies, dysmorphic features, severe kyphoscoliosis, growth and mental retardation, and the absence of speech, in whom 35% of the cells carried a supernumerary ring chromosome 1. Fluorescence in situ hybridization (FISH) analysis using YAC/BAC clones spanning the region from 1p13 to 1q21 made it possible to determine the genomic content and structure of the ring(1), which was found to consist of the cytogenetic bands 1q21–22. A complex structure was delineated in the ring chromosome with a partial inverted duplication delimited by markers WI‐7732 and WI‐607, with WI‐7396 and WI‐8386 being the boundaries of the single copy segment. Comparison of the clinical signs of other patients with mosaic r(1) reported in the literature allowed the identification of a patient sharing a number of clinical signs including cataracts. Given that mutations of the GJA8 gene encoding connexin 50 (Cx50) and mapping to 1q21 have been associated with the presence of cataracts, it is possible that a gain in copy number or a rearrangement of GJA8 may contribute to cataractogenesis. 相似文献
99.
心电信号预处理与心电信号分析 总被引:2,自引:0,他引:2
本文介绍了在一种便携式心电监护仪器中是如何对心电数据进行预处理和智能分析的.为了适应便携式仪器的特征,我们在心电信号预处理中采用了FFT滤波和滑动平均滤波的方法去除各种干扰并使图像得以平滑,同时采用了差分阈值法提取特征点,考虑到监护仪器的实用性,在心电信号分析阶段,我们采用了分析特征间期异常情况的方法来替代对病症的智能诊断功能。 相似文献
100.
Fuzzy rules to predict degree of malignancy in brain glioma 总被引:2,自引:0,他引:2
Ye CZ Yang J Geng DY Zhou Y Chen NY 《Medical & biological engineering & computing》2002,40(2):145-152
The current pre-operative assessment of the degree of malignancy in brain glioma is based on magnetic resonance imaging (MRI)
findings and clinical data. 280 cases were studied, of which 111 were high-grade malignancies and 169 were low-grade, so that
regular and interpretable patterns of the relationships between glioma MRI features and the degree of malignancy could be
acquired. However, as uncertainties in the data and missing values existed, a fuzzy rule extraction algorithm based on a fuzzy
min-max neural network (FMMNN) was used. The performance of a multi-layer perceptron network (MLP) trained with the error
back-propagation algorithm (BP), the decision tree algorithm ID3, nearest neighbour and the original fuzzy min-max neural
network were also evaluated. The results showed that two fuzzy decision rules on only six features achieved an accuracy of
84.6% (89.9% for low-grade and 76.6% for high-grade cases). Investigations with the proposed algorithm revealed that age,
mass effect, oedema, post-contrast enhancement, blood supply, calcification, haemorrhage and the signal intensity of the T1-weighted
image were important diagnostic factors. 相似文献