Systematic review,meta-analysis with subgroup analysis of hypnotherapy for irritable bowel syndrome,effect of intervention characteristics

BackgroundHypnotherapy has been shown to be effective at relieving global gastrointestinal symptoms (GGS) in irritable bowel syndrome (IBS). This study examines the impact of hypnotherapy delivery and participant characteristics on IBS outcomes.MethodsThis systematic review searched CINAHL, Cochrane Library, Conference Citation Index, Embase, PubMed, PsycARTICLES, PsychINFO, Science Citation index-expanded, Social Science Citation Index. Titles and abstracts, then full-text articles were screened against inclusion criteria: trials with a concurrent comparator of hypnotherapy in adults with IBS diagnosed using Manning or ROME criteria, which provided symptom data. Included studies were extracted and assessed for bias using Cochrane Collaboration 2011 guidance. Random-effects meta-analysis was conducted with sub-group analysis to assess the impact of delivery characteristics on outcomes.ResultsTwelve trials were included, 7 in the meta-analyses. Hypnotherapy reduced the risk of GGS, but this was not statistically significant, (standardised mean difference (SMD) 0.24, [-0.06, 0.54], I² 66 %). Higher frequency of sessions (≥1/week) reduced GGS (SMD 0.45 [0.23,0.67] I² 0 %), as did higher volumes of intervention (≥8 sessions with ≥6 h of contact) (SMD 0.51 [0.27,0.76] I² 0 %) and group interventions (SMD 0.45 [0.03, 0.88] I² 62 %). Only volume of intervention produced a significant effect between the subgroups.ConclusionThis review suggests that high volume hypnotherapy is more beneficial than low and should be adopted for GDH. Both high frequency and group interventions are effective in reducing GGS in IBS. However, the sample size is small and more studies are needed to confirm this.     

辅助生殖技术助孕患者健康信息需求及干预的研究进展

辅助生殖技术助孕患者信息需求主要包括疾病就诊、治疗指导、治疗进展、躯体适应、医护支持、社会心理6个方面。该文对辅助生殖技术助孕患者治疗阶段的信息需求进行总结,综述以专科护士为支持主体的健康教育,以患者、同伴为主体的信息支持以及交互式健康信息交流模式的应用情况,以期为今后构建多元化辅助生殖技术助孕患者信息支持模式提供参考。     

基于时滞关联特征患者就诊反馈分析

抓取“微医网”医患评论数据，对其中时滞与患者满意度进行关联分析，并对评论内容进行主题挖掘，提取不同时滞区间内患者重点关注的内容。通过对患者评论文本不同时滞区间内容的分析，寻找满意度提升策略，以缓解医患关系。使用K-means将患者反馈数据根据就诊后时长反馈分为“短期”和“长期”，通过LDA主题提取模型，对满意度划分后的患者评论文本挖掘不同时滞区间内患者所关注的重点内容，将其差异进行对比分析发现，患者就诊满意度随着时滞呈现趋高现象，不同时滞文本显示患者评论维度大致相同，但随着时滞区间的转移，患者所关注的就诊体验内容也有所变化。     

体验式学习在护理临床教学中的应用研究进展

<正>体验式学习(experiential learning)是指学生从日常生活或他人构建的程序里获得亲身体验,之后进行反思、概括、讨论、评价等活动,最终产生新的认识、情感以及行动,并在实践中加以检验、运用,以指导后续行为的过程或能力[1]。20世纪80年代,Kolb系统阐述了体验式学习理论,该理论指出每名学生都有其最适合的学习方式,可通过学习方式调查表(Learning Styles Inventory,LSI)     

警惕极易误诊漏诊的神经梅毒

正大约公元1505年(511年前)梅毒传入我国~[1],当时称"杨梅疮"或"广疮"。我国最早有关梅毒的专著是明代韩懋编著的《杨梅疮论治方》,最早有关神经梅毒的论著则见于程玉麐教授于1939年编著、因抗日战争推迟于1948年出版的我国首部《神经病学》专著中。新中国成立前,列强入侵、国弱民穷,鸦片和娼妓泛滥,梅毒十分猖獗;新中国成立后,立     

从眼肌麻痹到脑干脑炎

正眼肌麻痹是神经内科常见临床症状与体征,主要表现为眼睑下垂、复视、眼球活动障碍和瞳孔改变,可发生于大脑皮质、脑干、海绵窦和眶上裂至眶内的任何部位~[1],分为核下周围性、核性、核间性和核上性眼肌麻痹,其中,因核上通路受双侧大脑皮质支配,且大脑皮质支配眼球协同运动,故核上性眼肌麻痹仅表现为协同运动障碍,即凝视麻痹~[2-3]。1951年,Bickerstaff和Cloake~[4]报告3例以眼肌麻     

Radiofrequency microtenotomy for plantar fasciitis: A systematic review and meta-analysis

BackgroundCurrently, there is limited evidence on outcomes for plantar fascia radiofrequency microtenotomy. An evidence-based systematic review and meta-analysis for outcomes of radiofrequency microtenotomy for the treatment of plantar fasciitis was conducted.MethodsA comprehensive evidence-based literature review of PubMed and Cochrane Databases was conducted in March 2019, which identified 11 relevant articles assessing the efficacy of plantar fascia radiofrequency microtenotomy. The studies were then assigned to a level of evidence (I–IV). Individual studies were reviewed to provide a grade of recommendation (A–C, I) according to the Wright classification in support of or against endoscopic plantar fascia release. Meta-analysis was performed for 7 of the studies that measured AOFAS scores.ResultsBased on the results of this evidence-based review, there was fair (grade B) evidence to support plantar fascia radiofrequency microtenotomy. There was a statistically significant mean increase of 40.9 in AOFAS scores post procedure.ConclusionThere was fair (grade B) evidence to recommend radiofrequency microtenotomy for plantar fasciitis. There is a need for more high quality level I randomized controlled trials with validated outcome measures to allow for stronger recommendations to be made.Level of evidenceLevel II, systematic review of level II studies.     

Denosumab in the management of Aneurysmal bone cyst

BackgroundAneurysmal bone cyst (ABC) is a benign, locally aggressive tumour that arises predominantly in long bones and spine. Following the encouraging results of denosumab use in Giant Cell Tumors (GCT) and the histological similarities between ABC and GCT, the interest on the role of denosumab in the therapeutic arsenal of the most advanced ABC is growing. The purpose of this literature review is to investigate the current state of knowledge about the use of denosumab in ABCs.MethodsA literature research was conducted through PUBMED, COCHRANE and GOOGLE SCHOLAR using the keywords “aneurysmal bone cyst” AND “denosumab”. Seventeen articles were included.ResultsA total of 43 cases were reported in the literature. There were 23 males, 20 females. The mean age was 15,9 ± 8,1 year. Pain relief and neurological improvement were rapid and sustained. Radiological assessment showed ossification and/or volume reduction in 36/39 patients. Eight patients (18,6%) presented a recurrence after or during denosumab therapy of whom 7 were adults. Adverse events occurred in 11 patients, 5 of them were admitted to the intensive care unit due to hypercalcemia.ConclusionDenosumab use in non-surgical ABCs has shown a positive impact in pain and neurological symptoms. The oncological outcome remains unclear with a recurrence rate of 18,6% during/after denosumab therapy, mostly in adults. However, regarding the potential clinical benefits, its use might be discussed in the most advanced cases. Further research and clinical trials are mandatory to precise its belonging in the therapeutic arsenal.     

新型冠状病毒与脑血管病的关系

自2019年12月起,2019冠状病毒病(COVID-19,又称新型冠状病毒肺炎)首先在武汉被发现,随后该病迅速蔓延至全国乃至其他国家。该病具有传播广、死亡及重症率高的特点,影响深远,引起国内外的广泛重视。而脑血管病同样为我国人群主要的慢性疾病,每年也可造成一定的死亡及致残风险。COVID-19的发病机制与脑血管病的危险因素以及脑血管病本身都有很密切的关系,易合并存在,引发院内感染。笔者根据COVID-19现有的资料结合以往相关疾病的临床经验对新型冠状病毒与脑血管疾病的关系做一归纳,以求更好地指导临床个体化诊疗。     

Hardly traceable pitfalls in medical review articles

The main purpose of review articles is to increase insight into the best possible practice for increasing the health condition of future subjects. This requires the collection of as many relevant data as possible from earlier case studies, but such data should be mutually independent. If the data from the reviewed single- or multi-case studies are not entirely mutually independent, the conclusions of the review study may easily – though not necessarily – become biased. This is shown on the basis of a 2020 systematic review about the effects of deep dry needling on spasticity and related physical disabilities. We analyzed this study by checking undisclosed possible overlaps regarding the subjects dealt with in the various case studies that were reviewed. This analysis raised also some questions about the accuracy of the number of subjects that had been treated, which is an aspects of which errors can commonly not be disclosed by the readers. The objective of our Letter is to show that insufficient attention by authors, editor and reviewers for an unambiguous presentation of the data regarding the subjects dealt with can make it impossible for readers to draw correct conclusions regarding the optimization of possible treatments.