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71.
The role of apoptosis in childhood Henoch–Schonlein purpura 总被引:2,自引:0,他引:2
Ozaltin F Besbas N Uckan D Tuncer M Topaloglu R Ozen S Saatci U Bakkaloglu A 《Clinical rheumatology》2003,22(4-5):265-267
The pathogenesis of vasculitis is complex and is yet to be fully elucidated, although it is known that inflammatory cells play a major role. Dysregulation of apoptosis and defective clearance of inflammatory cells could lead to the persistence of inflammation and excessive tissue injury. In this study we aimed to investigate Fas (CD95) and apoptosis on peripheral blood (PB) neutrophil and lymphocytes in Henoch–Schonlein purpura, both in the acute phase and after resolution to determine the role of apoptosis in this self-limited vasculitis. Leukocytoclastic vasculitis presenting with Henoch–Schonlein purpura (HSP) was diagnosed according to ACR 1990 criteria and confirmed by skin biopsy. Thirty-seven patients (22 boys, 15 girls) aged 2.5–17 years (9 ± 3.3) were enrolled in the study. Expression of CD95 and apoptosis were investigated by the annexin/PI method on peripheral blood neutrophils and lymphocytes in both the acute and the resolution phases of the disease. The mean neutrophil and lymphocyte CD95 expression was 65.4 ± 37.6% and 33.3 ± 7.3%, respectively, in the acute stage and 62.8 ± 44.2% and 41 ± 20%, respectively, in the resolution (P > 0.05). The percentage of apoptotic peripheral blood neutrophils and lymphocytes as determined by annexin positivity was 13.3 ± 11.31% and 8.6 ± 9.5%, respectively, during the acute phase and 4.6 ± 3.4% and 3.1 ± 3.1%, respectively, in the resolution (P = 0.002, P = 0.008). These results suggest that increased apoptotic process in the immune effector cells in the acute phase of the disease may play an important role in the early control of inflammatory response and repair in leukocytoclastic vasculitis, thereby contributing to the self-limited nature of the disease. 相似文献
72.
Citera G Arias MA Maldonado-Cocco JA Lázaro MA Rosemffet MG Brusco LI Scheines EJ Cardinalli DP 《Clinical rheumatology》2000,19(1):9-13
The aim of the study was to determine the possible effect of melatonin treatment on disturbed sleep, fatigue and pain symptoms
observed in fibromyalgia (FM) patients. Twenty-one consecutive patients with FM were included in an open 4-week-duration pilot
study. Before and after treatment with melatonin 3 mg at bedtime, patients were evaluated using tender point count by palpation
of 18 classic anatomical regions, pain score in four predesignated areas, pain severity on a 10 cm visual analogue scale (VAS),
sleep disturbances, fatigue, depression, anxiety, and patient and physician global assessments, also by a VAS. Urine 6-sulphatoxymelatonin
levels (aMT-6S) were measured in the patients and 20 age- and sex-matched controls. Nineteen patients completed the study.
One patient withdrew because of migraine and another was lost to follow-up. At day 30, median values for the tender point
count and severity of pain at selected points, patient and physician global assessments and VAS for sleep significantly improved
with melatonin treatment. Other variables improved but did not reach statistical significance. Adverse events were mild and
transient. Lower levels of aMT-6S were found in FM patients compared with normal median controls (±SD, 9.16 ± 7.9 μg/24 h
vs 16.8 ± 12.8 μg/24 h) (p= 0.06). Although this is an open study, our preliminary results suggest that melatonin can be an alternative and safe treatment
for patients with FM. Double-blind placebo controlled studies are needed.
Received: 14 September 1998 / Accepted: 14 May 1999 相似文献
73.
Summary Human growth hormone (HGH) has recently been shown to play a prominent role in the control of blood glucose homeostasis. Furthermore, it has long been known that administration of growth hormone in animals can induce a diabetes-like state. In human subjects, exogenous administration of HGH or hypersecretion of the endogenous hormone in acromegaly is accompanied by glucose intolerance in only about 25 per cent of the cases. — In this paper, data are presented which give a more diversified picture of the so-called diabetogenic action of HGH. It is suggested that HGH, although decreasing the peripheral utilization of glucose, is not a primary diabetogenic factor, since its insulinogenic action causes a compensatory hyperinsulinism, with normal glucose tolerance as the result. HGH is diabetogenic only in prediabetic subjects whose pancreas is unable to respond to the insulinogenic effect of the hormone. In such subjects, the diabetogenic action of HGH not being counterbalanced by a compensatory hyperinsulinism, glucose intolerance may result. Thus, HGH may be regarded as anadditional factor for the development of diabetes, the major prerequisite being a preëxisting prediabetic state.Presented as an invited lecture at the VI Acta Endocrinologica Congress, Helsinki, Finland, August 8th–12th, 1967. 相似文献
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76.
肝细胞损伤的分子生物学机制 总被引:5,自引:0,他引:5
随着医学研究的不断进展,我们对各种肝脏疾病的病因有了更加深入的了解,对疾病的治疗也渐渐从对症治疗转移到病因治疗,但是,在强调病因学治疗的同时,不应忽略对肝细胞的保护,因为肝细胞损伤是各型肝病共同的病理基础,是各种原因引起肝脏疾病的共同的表现. 相似文献
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80.
Quanjun Cui Woo-Lam Jo Kyung-Hoi Koo Edward Y. Cheng Wolf Drescher Stuart B. Goodman Yong-Chan Ha Phillippe Hernigou Lynne C. Jones Shin-Yoon Kim Kyu Sang Lee Mel S. Lee Yun Jong Lee Michael A. Mont Nobuhiko Sugano John Taliaferro Takuaki Yamamoto Dewei Zhao 《Journal of Korean medical science》2021,36(10)
Osteonecrosis of the femoral head (ONFH) is a devastating disease frequently leading to femoral head collapse and hip arthritis. Specifically, non-traumatic ONFH primarily affects young and middle-aged adults. Although compromised local circulation of the femoral head seems to be pathognomonic for the disease, the pathogenesis is perplexing and continues to be an area of scrutiny and research. Comprehension of the pathogenesis is of crucial importance for developing and guiding treatments for the disease. Therefore, we provide an up-to-date consensus on the pathogenesis of non-traumatic ONFH. 相似文献