Purpose: To assess the levels of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with pseudoexfoliation syndrome (PEX) and to compare the NLR and PLR results of patients with PEX, PEX glaucoma (PXG), and healthy controls.
Methods: In total, 34 patients with PEX, 29 patients with PXG, and 42 healthy subjects were enrolled in this retrospective study. Complete ophthalmologic examination and complete blood count measurements were performed of all subjects. Complete blood counts were performed within 2 h of blood collection.
Results: There was a significant difference in NLR between PEX and control groups (p = 0.012) and PXG and control groups (p = 0.003). Also, a significant difference was found in PLR values between control and PXG groups (p = 0.024).
Conclusions: Our study for the first time provides evidence that PLR and NLR may be useful for predicting the prognosis of PEX patients and progression to PXG. 相似文献
目的 观察β-受体阻滞剂盐酸卡替洛尔滴眼液对患者24 h眼压的影响.方法 选取30例既往无抗青光眼药物使用史的患者,测量患者用药前24 h眼压(时间点为2:00 AM、6:00 AM、10:00 AM、2:00 PM、6:00 PM、10:00 PM).测量后给予患者盐酸卡替洛尔滴眼液点眼治疗,每天7:00 AM及7:00 PM各1次,每次1~2滴.观察患者用药15 d后的24 h眼压,并进行对比分析.结果 用药前患者24 h内6个检测点平均眼压分别为(19.77±2.51、19.52±2.34、20.38±2.71、20.07±3.65、19.97±4.10、19.97±4.31) mm Hg(1 mm Hg=0.133 kPa),用药后患者平均眼压分别为(17.12±2.38、17.42±2.60、18.18±2.36、18.02±3.77、17.72±3.17、17.35±3.40)mm Hg,用药前后患者平均眼压差异有统计学意义(t=11.68,P=0.000).其中用药前后日间平均眼压下降幅度为(2.46±2.05)mm Hg,夜间平均眼压下降幅度为(2.17±1.88) mm Hg,两者差异无统计学意义.结论 盐酸卡替洛尔滴眼液可有效降低患者眼压,其24 h降眼压幅度是稳定的.
Abstract:
Objective To investigate the effect of carteolol hydrochloride eye drops on 24-hour variation of intraocular pressure (IOP). Methods The 30 patients who had never used any anti-glaucoma eye drops were chosen, and their 24-hour variation of IOP (at 2:00 AM, 6:00 AM, 10:00 AM, 2:00 PM, 6:00 PM, 10:00 PM) were measured. Then carteolol hydrochloride eye drops were used twice a day (7:00 AM and 7:00 PM), 1-2 drops each time. Fifteen days later, their 24-h IOP was measured again and the data were analyzed. Results The average IOP at six monitoring points before treatment were (19.77±2.51) mm Hg, (19.52±2.34) mm Hg, (20.38±2.71) mm Hg, (20.07±3.65) mm Hg, (19.97±4.10) mm Hg and (19.97±4.31) mm Hg, the corresponding data after 15 days of treatment were (17.12±2.38) mm Hg, (17.42±2.60) mm Hg, (18.18±2.36) mm Hg, (18.02±3.77) mm Hg, (17.72±3.17) mm Hg and (17.35±3.40) mm Hg (t=11.68, P=0.000). The difference before and after treatment was (2.46±2.05) mm Hg during day and (2.17±1.88) mm Hg during night, and no significant difference was found between them. Conclusions Carteolol hydrochloride eye drops could significantly reduce the IOP, the decreased extent of 24-h IOP is stable. 相似文献