立体定向手术与内科治疗中小量基底核区高血压性脑出血的对比研究

目的研究中小量（15～40m1）基底核区高血压性脑出血应用立体定向治疗与内科保守治疗对患者病死率、运动功能及预后的影响。方法2003年1月～2013年1月,我院收治中小量基底核区高血压性脑出血164例,其中82例行立体定向手术抽吸结合尿激酶引流治疗,另82例行内科保守治疗。比较2组血肿清除时间、30d病死率、患侧肢体运动功能和90d格拉斯哥预后评分（Glasgow outcome score,GOS）。结果立体定向治疗组血肿消散时间（3.8±1.1）d,明显短于内科治疗组的（19.9±3.5）d（t=-39.463,P=0.000）。2组30d病死率差异无显著性。立体定向组治疗30d病肢肌力4～5级[43.9％（36／82）vs.28.0％（23／82）,X^2=4.474,P=0.034]和90 d GOS 5分者的比例明显高于内科治疗组[53.7％（44／82）vs.36.6％（30／82）,X^2=4.826,P=0.028]。结论对于中小量高血压性脑出血,行立体定向手术治疗比内科治疗能明显加快血肿清除时间,改善患者的功能预后。     

Nationwide survey of Arima syndrome: Revised diagnostic criteria from epidemiological analysis

Aim: We have never known any epidemiological study of Arima syndrome since it was first described in 1971. To investigate the number of Arima syndrome patients and clarify the clinical differences between Arima syndrome and Joubert syndrome, we performed the first nationwide survey of Arima syndrome, and herein report its results. Furthermore, we revised the diagnostic criteria for Arima syndrome. Methods: As a primary survey, we sent out self-administered questionnaires to most of the Japanese hospitals with a pediatric clinic, and facilities for persons with severe motor and intellectual disabilities, inquiring as to the number of patients having symptoms of Arima syndrome, including severe psychomotor delay, agenesis or hypoplasia of cerebellar vermis, renal dysfunction, visual dysfunction and with or without ptosis-like appearance. Next, as the second survey, we sent out detailed clinical questionnaires to the institutes having patients with two or more typical symptoms. Results: The response rate of the primary survey was 72.7% of hospitals with pediatric clinic, 63.5% of national hospitals and 66.7% of municipal and private facilities. The number of patients with 5 typical symptoms was 13 and that with 2–4 symptoms was 32. The response rate of the secondary survey was 52% (23 patients). After reviewing clinical features of 23 patients, we identified 7 Arima syndrome patients and 16 Joubert syndrome patients. Progressive renal dysfunction was noticed in all Arima syndrome patients, but in 33% of those with Joubert syndrome. Conclusion: It is sometimes difficult to distinguish Arima syndrome from Joubert syndrome. Some clinicians described a patient with Joubert syndrome and its complications of visual dysfunction and renal dysfunction, whose current diagnosis was Arima syndrome. Thus, the diagnosis of the two syndromes may be confused. Here, we revised the diagnostic criteria for Arima syndrome.     

Sentiments analysis at conceptual level making use of the Narrative Knowledge Representation Language

This paper illustrates some of the knowledge representation structures and inference procedures proper to a high-level, fully implemented conceptual language, NKRL (Narrative Knowledge Representation Language). The aim is to show how these tools can be used to deal, in a sentiment analysis/opinion mining context, with some common types of human (and non-human) “behaviors”. These behaviors correspond, in particular, to the concrete, mutual relationships among human and non-human characters that can be expressed under the form of non-fictional and real-time “narratives” (i.e., as logically and temporally structured sequences of “elementary events”).     

超声波对早孕蜕膜中免疫活性细胞影响的研究

采用诊断超声强度经腹部辐照宫腔.取早孕蜕膜,检测其中的免疫活性细胞,以探讨超声波对早孕蜕膜中免疫活性细胞的影响。结果表明:诊断超声强度未能影响早孕蜕膜中T淋巴细胞及其亚群的状态,却可使巨噬细胞数目减少,或许在一定程度上会削弱宫腔局部的抗感染能力。     

Liver transplantation

Huge developments in the field of liver transplantation have occurred over the last 30 years. Improved immunosuppression regimens brought about by the introduction of ciclosporin and tacrolimus, the development of organ preservation solutions and enhanced perioperative care have meant that survival at 1 year following liver transplantation now reaches approximately 90%. The spectrum of disease now treated with liver transplantation has also grown to encompass a wide range of chronic disease and primary liver malignancy. Early referral to specialist centres affords better outcomes for potential recipients and has prompted the development of specific scoring systems to objectively assess liver failure and guide organ allocation. The consistent gap between the number of recipients and availability of organs, however, has driven many new developments such as split grafts and live donor transplantation. The use of the marginal graft is now commonplace in many centres in an attempt to reduce waiting list mortality. Here, we examine the origins and evolution of the specialty and describe some of the latest developments in the field of liver transplantation, with specific reference to the surgical techniques currently used as well as recent advances in immunosuppression therapy.     

神经肌肉促进技术治疗脑卒中后足内翻疗效观察

目的:观察神经肌肉促进技术治疗脑卒中后足内翻的疗效。方法:将40例脑卒中患者分为神经肌肉促进技术组(治疗组)20例,一般治疗组(对照组)20例,两组均接受每日1次,每周5次的治疗,治疗次数10-40次。采用Brunnstrom评级进行疗效评定。结果:两组患者的Brunnstrom评级都有提高,但治疗组改善明显优于对照组(P<0.05)。结论:神经肌肉促进技术治疗治疗脑卒中后足内翻有显著的疗效。