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Transcatheter closure of ventricular septal defect in aortic valve prolapse and aortic regurgitation
《Indian heart journal》2018,70(4):528-532
ObjectiveTo report intermediate follow-up result of transcatheter closure of ventricular septal defect (VSD) in presence of aortic valve prolapse (AVP) with or without aortic regurgitation (AR).MethodThis is a retrospective review of 19 patients with VSD with AVP with AR who underwent transcatheter closure in between September 2011–July 2014. Mean age was 8 years (1–16 years, standard deviation [SD] 4.08 years) and mean weight was 26.03 kg (9–81.5 kg, SD 16.57 kg). Among them 2 had subarterial VSD, 6 had subaortic VSD and 11 had perimembranous VSD. All of them had mild AVP and 13 of them had AR (trivial or mild). Median VSD size was 4.3 mm (4–6 mm). Transcatheter closure was done either by retrograde technique using the Amplatzer Duct Occluder-II in 17 patients or antegrade technique using the Duct Occluder-I in 2 cases. Mean follow-up period was 18 months (12–36 months).ResultImmediate major complications were encountered in 2 (10.5%) cases. Significant aggravation of device related AR was seen in one case & device embolised to right pulmonary artery in another case and both of them were managed surgically.During follow up, 1 child had significant additional VSD requiring device closure. One child developed moderate AR, requiring surgery. None of the other had shown any increase in severity of AR.ConclusionDevice closure of VSD in presence of mild AVP and mild AR appears to be safe. Longer follow-up is necessary to draw final conclusion. 相似文献
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目的 探讨社区多部门系统干预模式对慢性精神分裂症患者症状、社会功能及生存质量的干预效果。方法 于2016年3—5月,采用方便抽样法选取上海市浦东新区花木社区卫生服务中心在册管理的、被明确诊断的精神分裂症患者128例为研究对象。随机分为对照组和干预组,每组各64例。对照组由社区卫生服务中心精神卫生防治工作者(精防工作者)按照目前浦东新区精神疾病管理方法对患者进行常规管理;干预组在对照组的基础上增加街道办事处、派出所、残疾人联合会、民办非企业单位(组织)等部门进行多部门管理。两组干预时间均持续1年。干预前和干预后1年时,分别采用阳性与阴性症状量表(PANSS)、个人和社会功能量表(PSP)、世界卫生组织生存质量测定量表简表(WHOQOL-BPRS)、家庭功能评定量表(FAD)评估患者症状、社会功能及生存质量。结果 干预前,两组患者PANSS、PSP、WHOQOL-BPRS、FAD评分比较,差异均无统计学意义(P>0.05)。干预后,干预组PANSS一般精神病理症状评分及总分低于对照组,PSP各项评分及总分高于对照组,WHOQOL-BPRS生理、社会关系评分及总分高于对照组,FAD问题解决、沟通、情感反应及总的功能评分低于对照组,差异有统计学意义(P<0.05);两组PANSS阳性症状、阴性症状评分,WHOQOL-BPRS心理、环境评分,FAD角色、情感介入、行为控制评分比较,差异无统计学意义(P>0.05)。结论 社区多部门系统干预模式能够有效改善慢性精神分裂症患者症状,提高其生存质量和社会功能,对精神分裂症患者的康复起到了积极作用。 相似文献
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Andreas Kaesler Felix Hesselmann Mark O. Zander Peter C. Schlanstein Georg Wagner Philipp Bruners Thomas Schmitz‐Rode Ulrich Steinseifer Jutta Arens 《Artificial organs》2019,43(2):159-166
The most common technical complication during ECMO is clot formation. A large clot inside a membrane oxygenator reduces effective membrane surface area and therefore gas transfer capabilities, and restricts blood flow through the device, resulting in an increased membrane oxygenator pressure drop (dpMO). The reasons for thrombotic events are manifold and highly patient specific. Thrombus formation inside the oxygenator during ECMO is usually unpredictable and remains an unsolved problem. Clot sizes and positions are well documented in literature for the Maquet Quadrox‐i Adult oxygenator based on CT data extracted from devices after patient treatment. Based on this data, the present study was designed to investigate the effects of large clots on purely technical parameters, for example, dpMO and gas transfer. Therefore, medical grade silicone was injected into the fiber bundle of the devices to replicate large clot positions and sizes. A total of six devices were tested in vitro with silicone clot volumes of 0, 30, 40, 50, 65, and 85 mL in accordance with ISO 7199. Gas transfer was measured by sampling blood pre and post device, as well as by sampling the exhaust gas at the devices’ outlet at blood flow rates of 0.5, 2.5, and 5.0 L/min. Pre and post device pressure was monitored to calculate the dpMO at the different blood flow rates. The dpMO was found to be a reliable parameter to indicate a large clot only in already advanced “clotting stages.” The CO2 concentration in the exhaust gas, however, was found to be sensitive to even small clot sizes and at low blood flows. Exhaust gas CO2 concentration can be monitored continuously and without any risks for the patient during ECMO therapy to provide additional information on the endurance of the oxygenator. This may help detect a clot formation and growth inside a membrane oxygenator during ECMO even if the increase in dpMO remains moderate. 相似文献
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Sheppard FR Keiser P Craft DW Gage F Robson M Brown TS Petersen K Sincock S Kasper M Hawksworth J Tadaki D Davis TA Stojadinovic A Elster E 《American journal of surgery》2010,200(4):489-357
Background
The microbiology of war wounds has changed as medicine and warfare have evolved. This study was designed to determine the microbial flora and bacterial quantification of present-day war wounds in US troops from Iraq and Afghanistan upon arrival at the National Naval Medical Center (NNMC).Methods
Patients with extremity combat wounds treated with a vacuum-assisted wound closure device were enrolled in study. Wounds were biopsied every 48 to 72 hours with quantitative microbiology performed on all biopsies.Results
Two hundred forty-two wound biopsies from 34 patients; 167 (69%) showed no growth, and 75 (31%) showed positive growth. The incidence of any bacterial isolation from biopsies weekly from the time of injury was 28% (first), 31% (second), and 37% (≥third). Acinetobacter baumannii was the most prevalent isolate.Conclusions
Most soft-tissue wounds from Iraq and Afghanistan do not have significant bacterial burden upon arrival to and during initial treatment at NNMC. Improved evaluation of combat wound microbiology at all levels of care is warranted to determine shifts in microbiology and to impact care practices. 相似文献109.
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