临床护理路径对慢性阻塞性肺疾病患者的影响

目的 探究临床护理路径对慢性阻塞性肺疾病患者的影响。方法 选择靖江市人民医院呼吸内科2016年7月至2017年6月收治的60例慢性阻塞性肺疾病患者为研究对象,随机分为实验组和对照组。实验组患者进行临床护理路径干预,对照组患者进行常规护理干预,比较两组患者护理前后的生活质量（GQOLI-74量表评分）、护理满意度、住院时间及治疗费用。结果 住院时两组患者的GQOLI-74量表中躯体、心理、社会、物质功能评分及总分差异均无统计学意义（P＞0.05）;护理干预后,实验组患者各领域得分及总分提高明显,与对照组比较差异有统计学意义（P＜0.05）;对照组护理干预前后各领域得分及总分提高不明显（P＞0.05）。实验组的护理满意度高于对照组（P＜0.05）,住院时间和治疗费用均低于对照组（P＜0.05）。结论 临床护理路径能够提高COPD患者的生活质量,减少住院时间和治疗费用,同时提高了患者对护理的满意度。     

增强现实技术与医药高等职业教育

增强现实技术作为新兴的技术在诸多领域有所应用,且逐渐受到关注。论文关注了增强现实（AR）技术在医药高等职业教育领域的应用前景,从的两者的契合度,AR技术可能的应用方向,存在的瓶颈和问题三个方面展望了AR技术给医药高等职业教育带来的机遇和问题。AR技术必将给医药高等职业教育发展与深化改革带来技术红利和技术保障。医药高等职业院校需积极转变思路、整合资源、培养开发人才,真正使得AR技术走进课堂。     

Resampling to Address the Winner's Curse in Genetic Association Analysis of Time to Event

The “winner's curse” is a subtle and difficult problem in interpretation of genetic association, in which association estimates from large‐scale gene detection studies are larger in magnitude than those from subsequent replication studies. This is practically important because use of a biased estimate from the original study will yield an underestimate of sample size requirements for replication, leaving the investigators with an underpowered study. Motivated by investigation of the genetics of type 1 diabetes complications in a longitudinal cohort of participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Genetics Study, we apply a bootstrap resampling method in analysis of time to nephropathy under a Cox proportional hazards model, examining 1,213 single‐nucleotide polymorphisms (SNPs) in 201 candidate genes custom genotyped in 1,361 white probands. Among 15 top‐ranked SNPs, bias reduction in log hazard ratio estimates ranges from 43.1% to 80.5%. In simulation studies based on the observed DCCT/EDIC genotype data, genome‐wide bootstrap estimates for false‐positive SNPs and for true‐positive SNPs with low‐to‐moderate power are closer to the true values than uncorrected naïve estimates, but tend to overcorrect SNPs with high power. This bias‐reduction technique is generally applicable for complex trait studies including quantitative, binary, and time‐to‐event traits.     

同时性多原发大肠癌治疗

目的：探讨同时性多原发大肠癌诊断和治疗效果。方法：对28例同时性多原发大肠癌患者的临床资料进行了回顾分析。结果：全部病例均行同期手术切除,根治性切除22例（78.57%）。5年生存率为57.1%,10年分别为35.7%,与同期大肠单癌病例根治性切除相比差异无统计学意义。结论：同时性多原发大肠癌根治性手术的效果与大肠单癌行根治性手术的效果相似,治疗原则是根治性切除手术。     

微型钛质钢板治疗锁骨中段粉碎性骨折患者预后影响因素调查研究

目的：观察应用微型钛质钢板治疗锁骨中段粉碎性骨折的临床效果并分析患者预后的影响因素。方法：锁骨中段粉碎性骨折的56例患者按照数字随机分组法分为对照组（n=25）和观察组（n=31),对照组患者采取克氏针内固定治疗,观察组患者采取微型钛质钢板治疗,比较临床疗效并判断患者预后的影响因素。结果：对照组的优良率低于观察组,观察组患者术中出血量、手术时间、骨折愈合时间、住院时间明显少于对照组,两组差异具有统计学意义（P＜0.05）。结论：应用微型钛质钢板治疗锁骨中段粉碎性骨折效果良好,能缩短手术时间和住院时间,减少影响骨折愈合的影响因素。     

协同护理在脑卒中患者中的应用分析

目的 分析协同护理干预措施在脑卒中患者中的应用效果.方法 将60例脑卒中患者随机均分为干预组和对照组(n=30),对照组进行医院科室的常规护理,干预组在接受医院常规护理的基础上实施协同护理.对2组患者神经功能、生活能力及生活质量进行对比分析.结果 干预2个月后,干预组患者神经功能状况、日常生活活动能力及生活质量水平改变显著好于对照组,差异具有统计学意义(P<0.05).结论 协同护理干预措施可明显提高脑卒中患者功能状态,有利于促进患者康复.     

深圳市常住人口就医机构选择意愿的简单对应分析研究

目的：了解深圳市常住人口对于不同类型的疾病选择不同医疗机构的差异性及倾向性。方法本课题对深圳市1613名15岁以上常住人口进行问卷调查表,了解深圳市常住人口对医疗机构选择的情况,基于简单对应分析探究深圳市常住人口的就医选择倾向。结果有66.8%的大病和住院患者选择市级医院就医,普通门诊中有35.9%首选市级医院,其次是选择社康中心就医,占26.1%,而患小病则多选择药店购药和社康中心就医,分别占44.6%和32.4%。简单对应分析结果与描述性统计结果一致。结论不同疾病类型对于不同医疗机构的选择具有明显的差异性;市级医院仍是大多数疾病患者的首选。     

Association of Resistance Exercise With the Incidence of Hypercholesterolemia in Men

Objective

To examine the associations of resistance exercise, independent of and combined with aerobic exercise, with the risk of development of hypercholesterolemia in men.

Quality of Life and Adaptation in People With Spinal Cord Injury: Response Shift Effects From 1 to 5 Years Postinjury

Objective

To investigate response shift effects in spinal cord injury (SCI) over 5 years postinjury.

Reasons for Distress Among Burn Survivors at 6, 12, and 24 Months Postdischarge: A Burn Injury Model System Investigation

Objective

To identify important sources of distress among burn survivors at discharge and 6, 12, and 24 months postinjury, and to examine if the distress related to these sources changed over time.