逆行荧光标记观察猫上橄榄复合体向内耳的投射

Objective To investigate the distribution and projective feature of cat olivocochlear neurons. Methods Eleven adult cats were divided into two groups randomly. The experimental group of eight cats was injected of I% cholera toxin B (CTB) to the left cochlea, while injected of 5% fluoro gold (FG) to the right cochlea. The control group of three cats was injected of saline to bilateral cochlea. After a survival time of 7 days, serial frozen sections were cut in the cat brainstem. All the sections were processed by immunofluoreseent procedure for CTB and FG, and the labeled olivocochlear neurons were observed byfluorescent microscope. Results In the experimental group, the mean total of olivocochlear neurons labeled by CTB and FG was 3210 ± 168, including lateral olivocochlear neurons (LOC, 2298 ± 120) and medial olivocochlear neurons (MOC,913 ± 64). The labeled neurons were divided into three different types according to their feature of projection: neurons which only projected to the ipsilateral cochlea, neurons which only projected to the contralateral cochlea, and double-labeled neurons which projected both to the ipsilateral and contralateral cochlea, but the double-labeled neurons comprised 3.9% and 15. 1% in the LOC and MOC system respectively. No labeled neurons were found in the control group. Conclusions There are three types of neurons in the cat olivocochlear system. The neurons which projected to the bilateral cochlea may distribute both in the LOC and MOC system.     

BCYB代数的理想和同构定理

本文使用一种新的方法引入了BCYB代数的理想的概念,并由此引入了BCYB代数的商代数,进而又定义了BCYB代数的同态、同构、同态的核等术语,最终导出了BCYB代数的第一同构定理和双商定理。     

间充质干细胞治疗椎间盘退行性疾病:基于Web of Science数据库的文献计量及可视化分析

背景:间充质干细胞具有自我更新和多向分化的特性,在治疗椎间盘疾病中具有巨大的潜力和应用前景.目的:针对间充质干细胞治疗椎间盘退行性疾病相关文献进行文献计量学分析,了解该领域的研究热点、发展趋势,为其后续发展提供依据和建议.方法:以间充质干细胞治疗椎间盘退行性疾病为主题,检索2000至2019年Web of Scienc...     

分析经皮椎间孔镜髓核摘除术治疗腰椎间盘突出症的疗效

目的:探讨使用经皮椎间孔镜髓核摘除术治疗腰椎间盘突出症的效果.方法:选取2019年1月至2020年5月期间云南省楚雄彝族自治州中医医院收治的64例腰椎间盘突出症患者作为研究对象.随机将这些患者分为参照组和治疗组.为参照组患者使用小切口开窗髓核摘除术进行治疗,为治疗组患者使用经皮椎间孔镜髓核摘除术进行治疗.然后观察两组患...     

The effect of folic acid on genetic damage induced by ethanol in human lymphoblast cell line

目的:探讨叶酸(folic acid,FA)对乙醇(ethanol,EtOH)诱发的人成淋巴细胞遗传损伤的影响.方法:人成淋巴细胞株GM12593培养在含有不同FA浓度(20、200、2 000 nmol/L)的RPMI-1640培养基中,并同时在每种FA浓度的培养体系中分别加入0.09％、0.36％和1.34％ (V/V)的EtOH,8 d后用细胞松弛素B(cytochalasin B,CB)处理28 h,胞质阻断微核细胞组分析(cytokinesis-block micronucleus cytome assay,CBMN Cyt)比较不同培养条件下的细胞遗传损伤,包括微核化双核细胞(micronucleated binueleated cell,MNed BNC)、核芽(nuclear bud,BUD)、核质桥(nucleoplasmic bridges,NPB)的频率差异.结果:乙醇在受试细胞中诱发MNed BNC、BUD和NBP频率显著升高(P＜0.01);2 000 nmol/L的叶酸能显著降低由乙醇诱发的MNed BNC、BUD和NBP频率(P＜0.01).结论:乙醇对细胞遗传物质具有损伤效应,叶酸对乙醇的遗传毒性具有防护效应.     

影响尿苷二磷酸葡醛酸转移酶活性的研究进展

尿甘二磷酸葡醛酸转移酶是重要的Ⅱ相代谢酶,尿甘二磷酸葡醛酸转移酶的活性对药物代谢和药物疗效具有重要影响。本文就影响尿甘二磷酸葡醛酸转移酶活性的主要因素年龄、激素水平、底物、疾病状态、遗传多态性以及基因表达调控作一综述。     

软产道损伤170例临床分析

目的:探讨分娩时软产道损伤的相关原因及合理防治措施.方法:对我院170例软产道损伤原因的分析、处理和预防措施.结果:其主要因素有产妇因素、助产因素、异常分娩、妊娠合并症.结论:我们要及时诊治软产道损伤,采取积极的预防措施,避免或减少软产道损伤的发生.     

核辐射,我们怎么办?

核能源作为新型能源,它能量大,成本低,开发潜力大,越来越受到国际普遍认识,日本地震所引发的核污染,引起人类对这类能源的新认识,核为放射性元素,对人体的损伤主要是甲状腺损伤,造血系统损害。面对核污染,我们应冷静,身着防护服,多吃维生素,补碘,室内通风,有助于降低核损害。     

抗转移性乳腺癌新药甲磺酸艾日布林

甲磺酸艾日布林(eribulin mesylate)是天然化合物软海绵素经结构优化后的大环酮类似物(代号E7389,ER-08652等),体内外试验结果显示其具有亚纳摩尔水平的抗肿瘤活性。2010年11月,甲磺酸艾日布林被美国FDA批准用于临床治疗至少接受过2种化疗方案(含蒽环类和紫杉类化疗药物)的转移性乳腺癌患者。本品商品名为HalavenTM,由Eisai公司开发上市。文中对其作用机制、药代动力学特性、I～III期临床研究结果以及安全性等进行综述。