由疫区医院SARS防治经验浅探突发性传染病防治模式

SARS暴发流行期间，疫区内医院面对复杂的社会环境、人群分布及致病原因不明、传染性强、传播途径不详、病情进展快、无特效治疗和收治条件有限等困难，通过健全疫情应急处理机制、启动卫生战备预案，按照管理传染源、切断传播途径、保护易感人群的方法，严格管理、科学治疗，取得了无院内交叉感染和无输入性病例发生的成绩，成功探索并实践了突发性传染病的防治模式。     

Impact of EGFR expression on colorectal cancer patient prognosis and survival.

BACKGROUND: Epidermal growth factor receptor (EGFR) is overexpressed in many types of cancers, especially colorectal cancer (CRC), and seems to reflect more aggressive histological and clinical behaviors. The aim of this study was to evaluate EGFR immunohistochemical reactivity in CRC biopsies, and to analyze its relationship with various histological and clinical characteristics and survival. PATIENTS AND METHODS: A composite EGFR score, obtained by multiplying the grade (% positive cells) by the intensity of labeling (0-9) was used to define patients with low or high EGFR expression whose clinicopathological features were then compared. Univariate tests and multivariate Cox proportional hazards model were applied for data analysis. RESULTS: Tissue sections from 150 CRC patients with a median follow-up of 40 months were examined. Median patient age at diagnosis was 70 years (range 38-89 years). EGFR reactivity was positive for 143 patients (97%) and high for 118 (80%). According to multivariate analysis, EGFR overexpression was significantly associated with tumor stage, with a higher percentage of EGFR overexpression in T3 than T4 (P=0.003) and not with overall survival. CONCLUSIONS: EGFR was overexpressed in this CRC patient population and was significantly associated with TNM (tumor-node-metastasis) stage T3. In the context of a new therapeutic strategy using EGFR-targeted therapies, although EGFR remains a controversial prognostic factor, this expression-stage association may play a crucial role in a decision to initiate an adjuvant treatment.     

脑卒中患者医院感染调查分析及护理对策

目的为了解脑卒中患者医院感染的发生和易感因素,有针对性地采取预防措施. 方法调查2001年1月～2002年12月,收住的202例脑卒中患者的医院感染,并设对照组进行对照分析. 结果发生医院感染34例、42例次,感染率为16.83%,例次感染率为20.79%;感染部位以下呼吸道和泌尿道感染最常见,构成比分别为38.1%、30.95%,感染组、非感染组在应用抗生素、侵入性操作、年龄、住院天数比较,两组均存在着显著性差异.结论脑卒中患者医院感染发生率明显高于我院两年平均医院感染率4.03%,明显高于卫生部医院感染管理规范中医院感染发生率应在3%～8%的规定范围,脑卒中患者是医院感染的高危人群,应成为重点防护对象.     

老年高血压的临床特点及治疗策略

高血压严重影响老年人的健康,是老年人发生脑卒中、冠心病、心肌梗塞、充血性心衰、肾功能衰竭等疾病的主要危险因素之一。但我国高血压病的预防率、控制率、治疗率均较低,并且发病率、并发症及死亡率高。本文就老年高血压的特点及治疗作一综述,旨在为老年高血压患者的临床诊治提供一定帮助。     

世界卫生组织耐药结核病治疗整合指南(2020年版)解读

1993年结核病被世界卫生组织宣布为"全球公共卫生紧急事件"。在复杂和严峻的大背景下,世界卫生组织发布了耐药结核病治疗整合指南(2020年版),相信有助于加速推动终止结核病策略的进程,扭转当前耐药结核病防治的被动局面。本文分别从异烟肼耐药结核病、含贝达喹啉全口服短程方案治疗耐多药结核病(MDR-TB)和利福平耐药结核病...     

Identification of RAD51–BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry

RAD51 is an ATP-dependent recombinase, recruited by BRCA2 to mediate DNA double-strand breaks repair through homologous recombination and represents an attractive cancer drug target. Herein, we applied for the first-time protein-templated dynamic combinatorial chemistry on RAD51 as a hit identification strategy. Upon design of N-acylhydrazone-based dynamic combinatorial libraries, RAD51 showed a clear templating effect, amplifying 19 N-acylhydrazones. Screening against the RAD51–BRCA2 protein–protein interaction via ELISA assay afforded 10 inhibitors in the micromolar range. Further ¹⁹F NMR experiments revealed that 7 could bind RAD51 and be displaced by BRC4, suggesting an interaction in the same binding pocket of BRCA2. These results proved not only that ptDCC could be successfully applied on full-length oligomeric RAD51, but also that it could address the need of alternative strategies toward the identification of small-molecule PPI inhibitors.     

发展广东中药工业的思路

通过对广东中药工业现状的分析,提出大力调整产业结构,实施“大广药”名牌战略,注重改善中药品种、技术结构和剂型结构,提高产品外向度,提升医药投资引力,进一步完善中药产业发展政策措施等发展思路。     

新药临床试验中的桥接试验

目的：介绍新药临床试验中桥接试验的概念和实施策略。方法：本文介绍了ICH E5中提出的桥接试验的概念和亚洲桥接试验的现况，结合实例介绍了桥接策略的具体实施。结果：随着ICH E5的发布以及桥接试验在一些国家和地区的成功实施，桥接试验已经成为新药注册申请的一个重要形式。结论：桥接试验对于外推国外的临床试验数据，判断药品种族差异，减少重复试验。缩短新药审批时间将有重要的意义。     

《伤寒论》两英文译本翻译方法的对此分析

选取在国内外影响较广的两个《伤寒论》的英文译本,摘取其中较具代表性的句式进行比较和分析,希望对中医典籍的翻译工作带来帮助和启发.     

大型三甲医院静脉用药调配中心COVID-19疫情防控策略

目的：总结COVID-19疫区大型三甲医院静脉用药调配中心（简称PIVAS）防控策略,为全国大型医院PIVAS面对突发公共卫生事件时提供参考。方法：将PIVAS区域五级细分,对各区域清洁消毒和人员进出实行分级管理,加强重点物资管理,同时合理调配人力资源,强化防疫知识培训,关注员工身心健康,给予人文关怀。结果：COVID-19疫情期间,PIVAS有序运行,保障了输液质量安全,有利于降低临床配液压力,在疫情防控中发挥了重要作用。结论：面对突发COVID-19事件,需要及时出台强有力的应对决策,并严格遵循,落到实处。通过科学防控、理性应战,一定能打赢COVID-19战役。