全文获取类型
收费全文 | 273342篇 |
免费 | 35189篇 |
国内免费 | 10853篇 |
专业分类
耳鼻咽喉 | 1831篇 |
儿科学 | 3615篇 |
妇产科学 | 5519篇 |
基础医学 | 20583篇 |
口腔科学 | 3043篇 |
临床医学 | 23150篇 |
内科学 | 39230篇 |
皮肤病学 | 1869篇 |
神经病学 | 2677篇 |
特种医学 | 8379篇 |
外国民族医学 | 269篇 |
外科学 | 36886篇 |
综合类 | 37093篇 |
现状与发展 | 61篇 |
一般理论 | 3篇 |
预防医学 | 14720篇 |
眼科学 | 1374篇 |
药学 | 20474篇 |
164篇 | |
中国医学 | 9385篇 |
肿瘤学 | 89059篇 |
出版年
2024年 | 897篇 |
2023年 | 5912篇 |
2022年 | 11014篇 |
2021年 | 14372篇 |
2020年 | 13507篇 |
2019年 | 12151篇 |
2018年 | 11717篇 |
2017年 | 12320篇 |
2016年 | 13385篇 |
2015年 | 14881篇 |
2014年 | 21493篇 |
2013年 | 21553篇 |
2012年 | 17256篇 |
2011年 | 17910篇 |
2010年 | 13261篇 |
2009年 | 13343篇 |
2008年 | 13625篇 |
2007年 | 12921篇 |
2006年 | 11732篇 |
2005年 | 9582篇 |
2004年 | 7919篇 |
2003年 | 6648篇 |
2002年 | 5728篇 |
2001年 | 5195篇 |
2000年 | 4337篇 |
1999年 | 3663篇 |
1998年 | 3162篇 |
1997年 | 2779篇 |
1996年 | 2342篇 |
1995年 | 2109篇 |
1994年 | 1807篇 |
1993年 | 1463篇 |
1992年 | 1303篇 |
1991年 | 1177篇 |
1990年 | 917篇 |
1989年 | 804篇 |
1988年 | 706篇 |
1987年 | 594篇 |
1986年 | 495篇 |
1985年 | 651篇 |
1984年 | 515篇 |
1983年 | 348篇 |
1982年 | 391篇 |
1981年 | 337篇 |
1980年 | 293篇 |
1979年 | 216篇 |
1978年 | 178篇 |
1977年 | 136篇 |
1976年 | 144篇 |
1975年 | 74篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
101.
BackgroundNowadays surgery remains the gold standard of treatment for tongue cancer. Via a more clear and precise terminology, the glossectomy classification by Ansarin et al. facilitates shared communication between surgeons, allowing comparison between published research and improving surgical practice and patient care. To establish the association of glossectomies, according to their classification by Ansarin et al. with overall survival (OS), disease-free survival (DSF), and cause-specific survival (CSS) in tongue cancer, we conducted a systemic retrospective study on 300 consecutive patients affected by primary oral tongue cancer and treated with surgery at the European Institute of Oncology, IRCCS (IEO).MethodsThree hundred patients with tongue squamous cell carcinoma and treated at the Division of Otorhinolaryngology and Head and Neck Surgery of the European Institute of Oncology, IRCCS were cataloged according to the glossectomy classification. OS, DFS, and CSS were compared by surgical treatments.ResultsOS-5yrs was 80% for the type I glossectomy group, 75% for type II, 65% for type III, and 35% for type IV-V. DFS-5yrs was 74%, 60%, 55%, and 27%, respectively for I, II, III, and IV-V glossectomy group; CSS-5yrs was 82%, 80%, 72%, and 48%, respectively for I, II, III, and IV-V glossectomy group (p < 0.01).ConclusionsThis study confirmed that the application of the glossectomy classification was statistically correlated with patients' oncological outcomes. 相似文献
102.
103.
104.
Willy Baccaglini Felipe A. Glina Cristiano Linck Pazeto Luis G. Medina Fernando Korkes Wanderley M. Bernardo Rene Sotelo Sidney Glina Giancarlo Marra Marco Moschini Xavier Cathelineau Rafael Sanchez-Salas 《Clinical genitourinary cancer》2021,19(1):3-11.e1
This meta-analysis focuses on the accuracy of upgrading to clinically significant prostate cancer (PCa) by multiparametric magnetic resonance imaging-targeted biopsy (MRI-TB) versus systematic biopsy (SB). We searched the Medline, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, and Literatura Latino Americana em Ciências da Saúde databases through January 2020 for comparative, retrospective/prospective, paired-cohort, and randomized clinical trials with paired comparisons. The population consisted of patients with low-risk PCa in active surveillance with at least 1 index lesion on imaging. We evaluated the quality of evidence by using the Quality Assessment of Diagnostic Accuracy Studies-2 score. Group comparisons considered the differences between the area under the curve summary receiver operating characteristic curve in a 2-tailed method. We also compared the positive predictive value of the best single method (MRI-TB or SB) and the referral study test (combined biopsy, a combination of MRI-TB and SB). The meta-analysis included 6 studies enrolling 741 patients. The pooled sensitivity for the 2 groups was 0.79 (95% confidence interval, 0.74-0.83; I2 = 75%) and 0.67 (95% confidence interval, 0.63-0.74; I2 = 55.4%), respectively. The area under the curve for the MRI-TB and SB groups were 0.99 and 0.92 (P < .001), respectively. The positive predictive value for the MRI-TB and combined biopsy groups were similar. The accumulated evidence suggests better results for MRI-TB compared with SB. Therefore, use of MRI-TB alone may be preferable in patients in active surveillance harboring low-risk PCa. 相似文献
105.
目的 探讨人格特征对喉鳞状细胞癌(LSCC)患者术后近期心理健康状况的影响。方法 纳入2017年1月—2019年12月在湖北省肿瘤医院行手术治疗的119例男性LSCC患者,术后5~7 d采用SCL-90、SAS、SDS自评量表评估术后心理状态,采用EPQ问卷测评患者的人格特征。多元线性逐步回归方法分析LSCC患者术后近期SAS和SDS评分的影响因素。结果 男性LSCC患者术后SCL-90、SAS、SDS得分显著高于中国常模(P≤0.05),EPQ中精神质(P)量表和神经质(N)量表得分高于中国常模(P<0.01)。男性LSCC患者术后躯体化、强迫、焦虑、抑郁、敌对、恐怖、偏执、精神病性因子得分均显著高于中国常模(P<0.05)。家庭收入、手术方式、术后近期是否行放化疗、P和N人格特征是术后SAS评分的影响因素(均P<0.01);家庭收入、手术方式、术后近期是否行放化疗和N人格特征是术后SDS评分的影响因素(P<0.01)。结论 LSCC患者术后近期存在抑郁、焦虑等心理障碍;具有P和N人格特征;家庭收入、手术方式、术后近期是否行放化疗以及P和N人格特征是影响术后SAS及SDS评分的独立危险因素。 相似文献
106.
107.
108.
目的:研究乳腺癌细胞中转录调节因子c-Myb的表达对肺转移的影响及其分子机制。方法:构建c-Myb高表达的4T1乳腺癌细胞株,种植小鼠构建乳腺癌动物模型,检测实验动物肺转移情况,通过荷瘤抑制试验检测肺转移抑制效果。提取组织进行荧光PCR检测相关炎症因子的表达。利用Medisapiens数据库的生物信息学资源,对c-Myb和Ccl2的表达与乳腺癌患者的预后进行分析。结果:高表达c-Myb的荷瘤小鼠肺部转移灶明显减少,其中炎症相关因子表达受限。由数据库分析得出,c-Myb高表达患者生存期得以延长。结论:乳腺癌中c-Myb的表达能够通过炎症因子Ccl2抑制肺转移从而延长患者生存期。 相似文献
109.
W. Do T. Elzerman R. de Bree A. Rosenberg T. Forouzanfar E.M. Van Cann 《International journal of oral and maxillofacial surgery》2021,50(5):591-597
The aim of this study was to analyse the effect of body mass index (BMI), both low and high values, on the perioperative complication rate in patients with oral squamous cell carcinoma (OSCC). The medical records of 259 patients operated between 2014 and 2017 for OSCC were reviewed. Univariate and multivariate analyses were performed. Sixty of the 259 patients developed 87 complications. Low or high BMI was not associated with the perioperative complication rate. A longer operating time and increased blood loss were associated with a higher perioperative complication rate and higher Clavien–Dindo grade. Low BMI, American Society of Anesthesiologists score 2 and 3, a longer operating time, and increased blood loss were associated with a longer hospital stay. Low BMI was associated with a longer hospital stay. Neither low nor high BMI was associated with the perioperative complication rate. A longer operating time and increased blood loss were associated with a higher perioperative complication rate and higher Clavien–Dindo grade. 相似文献
110.