全文获取类型
收费全文 | 65000篇 |
免费 | 2211篇 |
国内免费 | 456篇 |
专业分类
耳鼻咽喉 | 390篇 |
儿科学 | 693篇 |
妇产科学 | 586篇 |
基础医学 | 7024篇 |
口腔科学 | 4558篇 |
临床医学 | 4565篇 |
内科学 | 11994篇 |
皮肤病学 | 1337篇 |
神经病学 | 5138篇 |
特种医学 | 1583篇 |
外国民族医学 | 1篇 |
外科学 | 12266篇 |
综合类 | 3209篇 |
现状与发展 | 1篇 |
一般理论 | 5篇 |
预防医学 | 4962篇 |
眼科学 | 1138篇 |
药学 | 3900篇 |
17篇 | |
中国医学 | 2329篇 |
肿瘤学 | 1971篇 |
出版年
2024年 | 95篇 |
2023年 | 586篇 |
2022年 | 980篇 |
2021年 | 1949篇 |
2020年 | 1175篇 |
2019年 | 5063篇 |
2018年 | 5302篇 |
2017年 | 3354篇 |
2016年 | 964篇 |
2015年 | 933篇 |
2014年 | 1653篇 |
2013年 | 1776篇 |
2012年 | 1318篇 |
2011年 | 1575篇 |
2010年 | 1347篇 |
2009年 | 1057篇 |
2008年 | 1048篇 |
2007年 | 1005篇 |
2006年 | 920篇 |
2005年 | 734篇 |
2004年 | 611篇 |
2003年 | 630篇 |
2002年 | 452篇 |
2001年 | 501篇 |
2000年 | 384篇 |
1999年 | 379篇 |
1998年 | 223篇 |
1997年 | 220篇 |
1996年 | 177篇 |
1995年 | 180篇 |
1994年 | 152篇 |
1993年 | 140篇 |
1992年 | 132篇 |
1991年 | 122篇 |
1990年 | 76篇 |
1989年 | 86篇 |
1987年 | 82篇 |
1985年 | 2825篇 |
1984年 | 3372篇 |
1983年 | 2859篇 |
1982年 | 3324篇 |
1981年 | 3018篇 |
1980年 | 2509篇 |
1979年 | 2496篇 |
1978年 | 2061篇 |
1977年 | 1529篇 |
1976年 | 1992篇 |
1975年 | 1511篇 |
1974年 | 1322篇 |
1973年 | 1271篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
993.
YU Chun Hong JIANG Liang WANG Ying CUI Ning Xuan ZHAO Xiao YI Zong Chun 《Biomedical and environmental sciences : BES》2018,31(3):247-251
正This study investigated the effects of N-acetylcysteine(NAC)and ascorbic acid(AA)on hemin-induced K562 cell erythroid differentiation and the role of reactive oxygen species(ROS)in this process.Hemin increased ROS levels in a concentration-dependent manner,whereas NAC and AA had opposite effects.Both NAC and AA eliminated transient increased ROS levels after hemin treatment,inhibited hemin-induced 相似文献
994.
995.
Organisation‐based self‐esteem mediates the effects of social support and job satisfaction on intention to stay in nurses
下载免费PDF全文
![点击此处可从《Journal of nursing management》网站下载免费的PDF全文](/ch/ext_images/free.gif)
996.
997.
Intra-articular fractures of the calcaneus typically occur in individuals working on ladders, scaffolding or roofs. Male individuals in their productive age are most at risk. The functional problems that frequently persist are a well-known risk since they may obstruct a safe resumption of the former job. According to the data of the National Institute for Sickness and Invalidity Insurance the number of calcaneal fractures in Belgium have stabilised over the last ten years. These figures indicate the necessity for a better prevention policy. Scientific literature about the problem of impairment and disability in these cases is rare and lacks uniformity. A retrospective study was therefore performed on 65 private insurance compensation patients who were treated for intra-articular calcaneal fractures. The mean period of work incapacity was 260.5 days and the mean percentage of impairment was 12.3%. A large group (86.2%) were able to resume their former activities including the height workers. More than half of the patients (57%) needed a supportive device. Working at heights and falls from a height were a significant risk factor for long-term work incapacity. The figures are compared with the limited literature and further discussed. 相似文献
998.
《药学学报(英文版)》2021,11(8):2469-2487
Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo correlations (IVIVCs) for LBFs is quite challenging, owing to a complex in vivo processing of these formulations. In this paper, we start with a brief introduction on the gastrointestinal digestion of lipid/LBFs and its relation to enhanced oral drug absorption; based on the concept of IVIVCs, the current status of in vitro models to establish IVIVCs for LBFs is reviewed, while future perspectives in this field are discussed. In vitro tests, which facilitate the understanding and prediction of the in vivo performance of solid dosage forms, frequently fail to mimic the in vivo processing of LBFs, leading to inconsistent results. In vitro digestion models, which more closely simulate gastrointestinal physiology, are a more promising option. Despite some successes in IVIVC modeling, the accuracy and consistency of these models are yet to be validated, particularly for human data. A reliable IVIVC model can not only reduce the risk, time, and cost of formulation development but can also contribute to the formulation design and optimization, thus promoting the clinical translation of LBFs. 相似文献
999.
Aleksandra Cieluch Aleksandra Uruska Marcin Nowicki Ewa Wysocka Agata Grzelka-Woźniak Justyna Flotyńska Paweł Niedźwiecki Dorota Zozulińska-Ziółkiewicz 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(4):1219-1226
Background and aimsCholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) are crucial proteins in reverse cholesterol transport. There are insufficient data on regulating these proteins by insulin therapy in type 1 diabetes mellitus (T1DM). We aimed to assess prospectively the impact of insulin therapy initiation on transfer proteins serum levels in adults with newly diagnosed T1DM.Methods and results57 adults with newly diagnosed T1DM were enrolled in the InLipoDiab1 Study. All participants were treated with subcutaneous insulin in the model of intensive insulin therapy since the diagnosis of diabetes. Serum PLTP and CETP concentrations were measured at diagnosis, after three weeks, six months, and after one year of insulin treatment, using the immunoenzymatic method ELISA.A significant decrease in PLTP and CETP concentrations were demonstrated during twelve months of insulin therapy in newly diagnosed T1DM. The dynamics of changes in the level of these proteins varied depending on the occurrence of remission after a year of the disease. In the group without remission, a significant decrease in PLTP and CETP levels appeared after six months of follow-up. The remission group was characterized by a decrease in proteins concentration only after one year of treatment. In the non-remission group, significant negative correlations were found between the daily dose of insulin and levels of PLTP and CETP.ConclusionExogenous insulin is an inhibitor of lipid transfer proteins involved in high-density lipoprotein cholesterol metabolism in the first year of treatment. 相似文献
1000.