雷公藤多苷治疗RA起效用药量研究

【目的】研究中药雷公藤多苷治疗类风湿关节炎（RA）的起效用药量，以指导临床合理用劲。【方法】采用回顾性分析的方法收集567例用雷公藤多苷治疗RA患者病例，根据其治疗效果分改善、进步、明显进步3级，研究病情改善程度与服药时间及剂量的关系。【结果】进步与改善所需平均服药剂量有显著性差异（P〈0．05），而进步与明显进步所需平均服药时间无显著性差异（P〉0．05）口【结论】在一定的范围内，雷公藤多苷的服用剂量和疗效成正相关。因此，雷公藤多苷需在最大有效用药量范围内足时足量服用，以期达到最佳治疗效果。     

ED-NM-MO三联法对丹参三七配比的多目标优化研究

[目的]采用ED-NM-MO三联法对经基线等比增减设计的丹参、三七不同配比的药效学数据进行非线性拟合和多目标优化。[方法]对经基线等比增减设计的丹参、三七不同配比的药效学数据,以心肌缺血程度Σ-ST、心肌缺血程度(缺血区左室)等7个分别反映心肌缺血、心脏状态和血流动力学的指标作为待优化的药效目标,进行非线性拟合和多目标优化。[结果]分别得到针对7个药效指标和6个药效指标(不包含血清中心肌钙蛋白)的Pareto最优配比。[结论]ED-NM-MO三联法是一种适合复方特点的优化方法,可以应用于由多饮片多组分多成分复方药物的剂量配比优化。     

基于中医脉诊三部理论的多导脉象检测系统

介绍了一种基于中医脉诊三部理论的可应用于实验动物的多导脉象检测系统。多路传感器信号经过处理通过USB传送至计算机,与自行开发的数据分析、处理软件配合,可以获得三个不同部位的压力脉搏图、一路标准心电信号以及一路光电容积脉搏图,经初步动物实验证明效果良好。     

Survey of the patients with cleft lip and palate in China who were funded for surgery by the Smile Train Program from 2000 to 2002

Background Cleft lip （CL） and cleft palate （CP） are two of the most frequent congenital malformations. Many epidemiologic studies on this deformity have been conducted worldwide, often producing inconsistent results. This study assessed epidemiology and some genetic aspects of cleft lip and palate in a Chinese sample from the Smile Train Program and to compare with other methodologically sound surveys. Methods The general information, family history, classification of cleft and associated malformations of 8000 CL and CP surgery patients were analyzed. Results Of the 8000 cases, 7812 had complete data. The distribution of cleft types is 17.04% with CP, 23.39% with CL and 59.58% with cleft lip and palate （CLP）. Unilateral clefts were more common than bilateral, with unilateral to bilateral ratios bein 10.4 ： 1 for CL, and 3.42 ： 1 for CLP. The overall male： female ratio was 2.01 ： 1. Left sided defects were more common than right sided regardless of sex, 1.90 ： 1 for CL and 1.96 ： 1 for CLP. CLP and CL were more common in males than in females with sex ratios （SR） of 2.88 ： 1 and 1.85 ： 1 respectively, whereas CP was more common in females with SR of 0.76 ： 1. Associated malformations （2.89%）, involved 29 CP cases, 41 CL and 156 CLP. The frequency of associated malformations in CLP （3.35%） was higher than CL （2.24%） and CP （2.22%） （P〈0.05）. Patients with CP or CLP were born less often in the winter than in the summer （P〈0.05）. A history of family members having clefts occurred in 6.84% of patients. The proportion of CLP cases （7.56%） was significantly higher than that of CL cases （5.64%） （P〈0.05）. Conclusions The different types of clefts appeared in the highest proportion in CLP and lowest proportion in CP. Males are more common with CL and CLP and less common with CP. These characteristics are the same as those of other Chinese surveys but different from some European reports.     

Frosted cylindrical lens induced artefact on Humphrey automated perimetry

Background: The aim of this study was to assess the effect of a cylindrical corrective lens with frosted sides on Humphrey automated perimetry performed with a translucent spectacle occluder in the contralateral eye. Methods: Ten healthy volunteers with cylindrical refractive errors of more than 1.50 DC had Humphrey visual fields (30‐2) measured with the contralateral eye occluded with either a translucent spectacle occluder or an opaque patch. The order of testing with each occluder was randomised. Additionally, visual field examination with the opaque patch was performed on three volunteer subjects with deep‐set eyes to establish the clinical significance of the frosted cylindrical lens induced artefact (CLA). The back vertex distances for the correcting lenses were measured for all tests. Results: Eight out of 10 volunteers tested with the translucent occluder demonstrated CLA, which was absent when the opaque patch was used. The presence of an artefact corresponding to the axis of the cylinder was observed, when the vertex distance was more than 15 mm. Three subjects with deep‐set eyes presented with CLA, even with the use of an opaque patch. Discussion: Cylindrical lens artefacts can occur with increasing vertex distance when using a translucent spectacle occluder instead of an opaque patch. CLA is also seen in subjects with deep‐set eyes.     

放射治疗剂量学数据的简明管理方法

目的:设计一种基于微机的放射治疗剂量学数据的录入、显示、查询和处理的新管理方法。方法:根据归属将测量剂量学参数进行分类使之分属不同的层次,建立一个具有层次性结构的放射治疗剂量学数据库,按照该管理思想设计一个满足临床需要的软件系统。结果:将测量剂量学数据归类成适合层次管理的数据结构,开发了具有多种数据输入方式、剂量曲线显示、数据拟合、剂量转换、简单剂量计算和打印输出的软件系统。结论:放射治疗剂量学数据分层管理方法不仅方便、直观、可靠、快速,极利于数据的查询、验证和更新,而且很容易设计成软件系统。     

肿瘤伴发贫血及其对肿瘤患者生活质量影响的调查

目的 :探讨肿瘤伴发贫血及其对患者生活质量的影响。方法 :应用简明健康状况调查表 (SF 36简表 )对 2 6 3例恶性肿瘤患者进行生活质量调查评定 ,并分析这些患者的贫血情况与其他一些临床因素之间的关系及对生活质量的影响。结果 :1)在 2 6 3例患者中总贫血发生率为 4 8 3% ,其中泌尿生殖系统肿瘤贫血的发生率最高 ,为 70 6 % ;血液系统肿瘤发生 3、4级贫血的比例最高 ,为 2 9 2 %。不同病种发生贫血的比例之间差异有显著意义。 2 )随肿瘤分期的升高 ,贫血发生率逐渐升高 ,且存在统计学差异 ,说明进展期肿瘤更易发生贫血。 3)不同性别、年龄和病程发生贫血的比例差异无显著意义。 4 )贫血对生活质量影响的单因素分析显示 ,贫血对体能状态、精神状态和总体生活质量均有显著影响 ,随贫血的加重生活质量下降。 5 )对生活质量影响因素进行多元逐步回归 ,显示贫血对于体能状态、精神状态和总体生活质量均存影响。结论 :轻、中、重度贫血对患者的生活质量、体能状态和精神状态均有影响 ,且随着贫血的加重而加重 ,必须充分重视纠正贫血的重要性。     

RANDOM SYSTEMS OF HARD PARTICLES:MODELS AND STATISTICS

1　Ｉｎｔｒｏｄｕｃｔｉｏｎ　　Ｉｎｍａｎｙｓｉｔｕａｔｉｏｎｓ ,ｅｎｇｉｎｅｅｒｓａｎｄｓｃｉｅｎｔｉｓｔｓａｒｅｃｏｎ ｆｒｏｎｔｅｄｗｉｔｈｉｒｒｅｇｕｌａｒｓｐａｔｉａｌｓｔｒｕｃｔｕｒｅｓｗｈｉｃｈｃａｎｂｅｉｎ ｔｅｒｐｒｅｔｅｄａｎｄｍｏｄｅｌ     

气道炎症相关生物标记物的基因检测

目的 寻找变应性鼻炎(allergic rhinitis,AR)发展为变应性鼻炎合并哮喘的临床标记物. 方法 分别取季节性变应性鼻炎(seasonal allergic rhinitis,SAR)6例及SAR并发哮喘者5例患者的下鼻甲黏膜,提取总RNA,合成生物素标记的cRNA探针,与Affymetrix人类全基因组芯片HG-U133-plus2.0杂交、洗脱、染色和扫描,分析检测的数据.以反转录聚合酶链反应(RT-PCR)验证芯片结果;对差异表达基因结合GeneCard数据库、pubmed-NLM文献数据库进行综合数据挖掘(data mining).结果 在GeneCard数据库中查到与哮喘相关基因354个,变应性鼻炎相关基因45个,变应性哮喘(allergic asthma)相关基因13个;鳞状上皮细胞癌抗原KEA1(SERPINB3)、SCCA2(SERPINB4)基因在SAR合并哮喘者鼻黏膜较SAR者发生上调表达;进一步结合芯片数据和pubmed-NLM文献数据库分析提示SCCA1(SERPINB3)、SCCA2(SERPINB4)表达增高与AR并发哮喘相关. 结论 鼻黏膜中SCCA1、SCCA2表达水平有望成为预测SAR并发哮喘的临床相关生物标记物.     

医院信息系统的数据备份

随着网络信息化的快速发展,医院信息系统也得到了长足发展,这对网络的实时性和不间断性运转有了进一步要求。数据的安全性是系统正常运转的关键,而数据备份是加强安全性的重要措施。