Herpes simplex: The primary infection

A primary infection with herpes simplex virus (HSV) occurs at some time in the life of almost every member of the population, especially among those living in crowded, unsanitary conditions. In many cases the lesions are subclinical, and in most cases they are self-limited even when clinical. In a few patients, such as the newborn infant, the patient with concomitant eczema, or the patient with reduced immunity, the primary infection may become severe, generalized, and life-threatening. Type 1 HSV has a predilection for a number of sites, including the oral cavity, the eye, and the skin; and type 2 HSV has a predilection for the genital area and for the newborn.     

新型隐球菌性脑膜脑炎的临床和头颅MRI 6例分析

目的分析新型隐球菌性脑膜脑炎的临床特点及头颅MRI对其诊断的意义。方法回顾分析6例经病原学检查明确诊断的新型隐球菌性脑膜脑炎及影像学特点。结果新型隐球菌性脑膜脑炎起病隐袭,病程较长,临床表现多样,以头痛起病多见。4例病人头颅MRI有异常发现。结论头颅MRI对某些病人的早期诊断可能有一定的帮助。     

HIV 阴性的隐球菌性脑膜脑炎的 MRI 表现及临床意义

目的：评价磁共振成像(MRI)在人类免疫缺陷病毒(HIV)阴性的隐球菌性脑膜脑炎(CM)的表现及预后判断。方法回顾性分析2000—2013年于本院由脑脊液墨汁染色及脑脊液细菌培养确诊的19例 HIV 阴性的 CM 的 MRI 表现及临床预后,采用格拉斯哥结局评分量表进行预后判断：1分=死亡,2分=永久植物状态,3分=严重残疾,4分=中度残疾,5分=恢复良好。1~3分归为预后差,4~5分为预后良好。结果84.2%(16/19)的 MRI 检查异常,84.2%(16/19)表现为脑膜强化,31.6%(6/19)为脑肿胀,47.4%(9/19)为脑实质病变,5.2%(1/19)为血管炎。平均随访时间3.5年,9例 MRI 证实脑实质病变中5例(5/9,44.4%)出现预后不良。结论 HIV 阴性的 CM 的 MRI 表现多样,当出现脑实质病变可能提示预后不良。     

Failure of multiplex meningitis/encephalitis (ME) NAT during cryptococcal meningitis in solid organ recipients

Cryptococcal meningitis is a severe cause of central nervous system infections among immunocompromised solid organ transplant (SOT) patients. While new diagnostic methods as multiplex meningitis/encephalitis (ME) NAT (nucleic acid test) are increasingly used as a first‐line tool in hospital practice, data in HIV‐negative patients including SOT remain scarce. We report here false‐negative results of multiplex NAT among SOT patients with proven cryptococcal meningitis.     

An Autopsied Case of Acute Lymphocytic Meningoencephalitis with a Long Clinical Course: Special Reference to CT, MR, SPECT and Neuropathological Findings

Abstract: This report describes the clinico-pathological features of acute lymphocytic meningoencephalitis (ALME) of a patient with a long clinical course of 24 months. The patient rapidly developed a confusional state, occasionally with stupor, various involuntary movements and generalized convulsions followed by fever and headache at the age of 29. Clinical symptoms, except fever and convulsions, had not distinctly improved throughout the clinical course, and cortical atrophy on CT and MR gradually progressed. SPECT revealed a low blood perfusion in the cerebral cortices. Neuropathologically, inflammatory findings were very mild, but nerve cells degenerated prominently. From these clinicopathological findings, it is suggested that chronic degenerative changes followed an acute inflammatory phase.     

肺炎支原体肺炎38例分析

我科于１９９５年８月１日－１９９６年１月底共收治住院肺炎病例１７４例，全部病例均于发病后的４－１４天测定血清肺炎支原体抗体而确诊为肺炎支原体肺炎３８例，有１例病后第５天血清肺炎支原体抗体呈现阳性，本组病例以８－１１岁年龄期儿童患病率高共１９例并伴发多系统受累，３８例中，胸膜反应１例，胸膜炎１例，皮疹４例，呕吐４例，脑膜脑炎１例，谷草转所酶，谷现转氨酶，肌酸磷酸激酶，乳腺脱氢或高共５例，但无脏器衰竭     

广州管圆线虫性脑膜脑炎1例报告

报道1例临床罕见的广州管圆线虫感染性脑膜脑炎,并对其发病过程、临床特点、辅助检查结果及治疗情况进行了简要分析。