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11.
目的:探讨肺炎性假瘤的病理类型和临床特点;方法:根据1988年(HUNPATHOL)MATSUBRA等分型方法,对50例肺炎性假瘤进行临床病理分析;结果:机化肺炎型23例,纤维组织细胞型16例,淋巴浆细胞型11例;结论:肺炎性假瘤其性质均为良性,男性多于女性,共同的病理特点是纤维母细胞增生、血管增生,组织细胞、淋巴细胞、浆细胞浸润,肺泡细胞增殖。 相似文献
12.
Chemokine receptor CCR6 as a prognostic factor after hepatic resection for hepatocellular carcinoma 总被引:3,自引:0,他引:3
HIROKI UCHIDA YUKIO IWASHITA ATSUSHI SASAKI KOHEI SHIBATA TOSHIFUMI MATSUMOTO MASAYUKI OHTA SEIGO KITANO 《Journal of gastroenterology and hepatology》2006,21(1):161-168
Background and Aims: Chemokines and their receptors have recently been shown to have major roles in cancer metastasis. The aim of this study was to determine whether the interaction between chemokine receptor 6 (CCR6) and its ligand, macrophage inflammatory protein‐3 alpha (MIP‐3α), correlates with metastasis of hepatocellular carcinoma (HCC). Methods: To observe the reaction of CCR6 expressed cancer cells to MIP‐3α stimulation, chemotactic and actin polymerization assays for both CCR6 high cells (HepG2) and CCR6 low cells (MCF‐7) were performed. CCR6 mRNA levels in tumor specimens from 30 HCC patients were quantified by real‐time polymerase chain reaction. Patients were classified into two groups, high (≥ 20 copies; n = 10) CCR6 and low (<20 copies; n = 20) CCR6 on the basis of CCR6 expression, and the groups were compared with respect to clinicopathological features. Results: When HepG2 cells (CCR6 high) were stimulated with MIP‐3α, they migrated in a dose‐dependent manner, and formation of pseudopodia was observed. These phenomena were not observed in the CCR6 low cells. The incidence of intrahepatic metastasis was higher in the high CCR6 expression group than in the low CCR6 expression group (P < 0.05). Disease‐free survival was significantly poorer in the high CCR6 expression group than in the low CCR6 expression group (P < 0.05). Conclusions: It was indicated that CCR6 might be associated with intrahepatic metastasis of HCC and might be able to become one of the prognostic factor after hepatic resection for HCC. 相似文献
13.
目的 探讨膀胱前间隙炎性假瘤的临床病理特征及发病因素,以提高对本病的认识。方法 复习3例膀胱前间隙炎性假瘤的临床特征、组织病理学、免疫表型及相关文献。结果 3例患者均为女性,均为输卵管结扎术后1~2年发现膀胱前间隙炎性假瘤,CT及B超提示膀胱前壁肿块,但膀胱黏膜光滑。术中发现肿块位于膀胱前间隙并累及膀胱前壁。病理检查:眼观为灰白色质韧的结节状肿块,镜下见炎性假瘤的病理特征及不同程度炎症背景,有组织疏松区、黏液样区、部分区域梭形细胞和纤维母细胞排列杂乱,细胞较大,光镜检查时易误诊为肉瘤,但缺乏核异型。3例均成功行肿块连同部分膀胱壁切除术,随访3~5年无复发。结论 膀胱前间隙炎性假瘤形态上需与软组织肉瘤、结节性筋膜炎、术后梭形细胞结节、间质性膀胱炎等疾病相鉴别,既往输卵管结扎术和感染可能是其重要的致病因素。 相似文献
14.
S Rombouts† T Nijsten†‡ J Lambert† 《Journal of the European Academy of Dermatology and Venereology》2007,21(3):326-333
BACKGROUND: Previous studies on the association between smoking and acne have reported conflicting results. OBJECTIVE: To investigate the association between smoking and acne among school-going adolescents. METHODS: A cross-sectional study was conducted. Smoking was defined as smoking > 3 cigarettes daily for 6 months or more. We defined acne as having > 20 retentional and/or inflammatory facial acne lesions. Multivariate (proportional) logistic regression models were used to adjust for confounding variables. RESULTS: Of the 594 participants, 36.2% had acne. Acne sufferers were less likely to smoke (18.1 vs. 23.7%, P = 0.10). In girls, smoking was significantly associated with lower prevalence of acne (adjusted OR = 0.41, 95% CI = 0.13, 0.82). Smoking, daily cigarette consumption and duration of smoking appeared to be protective in the development of inflammatory acne in girls. No significant associations between acne and smoking variables were detected among boys. Limitations: although this study suggests a significant negative association between smoking and inflammatory acne in girls, it does not prove causality. This association did show a trend for linear relationship. Because of the unexpected differences between boys and girls, sample size may have affected our results. CONCLUSION: The anti-inflammatory effects of smoking may inhibit the development of papulopustular acne in girls more than in boys. However, smoking should not be considered a therapeutic option for acne. Additional studies that consider possible differences across age, gender and type of acne are needed to clarify the association between smoking and acne. 相似文献
15.
Lambros Lazuras Angelos Rodafinos Georgios Matsiggos Alexander Stamatoulakis 《Social science & medicine (1982)》2009
The present study examined four potential roles of work-related negative affectivity on the associations between self-reported occupational stress and physical well-being among telecommunication employees in Greece. Participants (764, predominantly male) completed a battery of self-report measures on perceived occupational stress, negative affectivity, and illness symptoms. In line with previous research, negative affectivity exerted a nuisance effect, by inflating the association between reported stressors and illness symptoms, and significantly predicted illness symptoms, over and above the effects of stressors. In addition, negative affectivity influenced reported illness symptom indirectly, through the effects of stressors, and moderated the relationship between interpersonal conflict at work and illness symptoms. The findings suggest that negative affectivity can largely explain and influence in different ways the associations between self-reported stress and physical strain. It is recommended that future studies of occupational stress should control for the effects of negative affectivity, and that health professionals should be cautious of its effects when interpreting relationships between self-reported occupational stress and physical well-being. 相似文献
16.
急性脑梗死诱发全身炎症反应综合征致多器官功能障碍综合征的临床研究 总被引:15,自引:2,他引:13
目的 探讨急性脑梗死 (ACI)诱发全身炎症反应综合征 (SIRS)致多器官功能障碍综合征(MODS)的发病机制 ,以及血清肿瘤坏死因子 (TNF α)、白细胞介素 (IL 1) β含量变化在ACI诱发SIRS发生、发展并向MODS转化的临床意义。方法 6 8例ACI患者根据病情变化分为 3组 ,其中单纯性ACI(SACI组 ) 36例 ,ACI致SIRS(SIRS组 ) 32例 ,ACI致SIRS后发展为MODS(MODS组 ) 2 4例 ;应用酶联免疫吸附法 (ELISA法 )分别测定患者不同病程中血清TNF α、IL 1β值 ,并与对照组 (为 2 8名同期健康体检者 )比较。 结果 (1) 6 8例ACI中 4 7.0 6 %发生SIRS;SIRS时 75 %发生MODS。 (2 )血清TNF α、IL 1β的含量MODS 组 >SIRS组 >SACI组 >对照组 ,各组间比较 ,差异具有极显著性 (均P <0 0 1)。MODS重症者 (积分≥ 9分 )血清TNF α、IL 1β含量高于轻症者 (积分 <9分 ) (均P <0 0 1) ;MODS死亡者血清TNF α、IL 1β含量高于存活者 (均 P <0 0 1)。结论 (1)ACI后出现SIRS可导致MODS的发生。 (2 )患者血清TNF α、IL 1β水平异常变化可作为判断ACI致SIRS、MODS病情进展、预后及转归的一项指标 相似文献
17.
33例肝占位性病变MRI误诊的分析 总被引:1,自引:0,他引:1
我院1988年以来4000余例腹部MRI中,发现肝占位性病变误诊33例。所用机型为美国Disonics公司0.5T超导MRI,自旋回波序列(SE序列)、常规T1加权(T1WI)、质子加权(PDWI)、T2加权(T2WI),覆盖全肝。其中,PHC误诊为MHC5例、MHC误诊为PHC6例、PHC误为HHE5例、MHC误诊为HHE2例、HHE误诊为PHC6例、肝硬化结节误诊为PHC2例、炎性假瘤误诊为PHC3例、肝结核误诊为PHC1例、HCY误诊为HHE3例。本文从病变的影像学特征和扫描技术方面详细探讨了误诊的原因和鉴别诊断要点。 相似文献
18.
S. Urien D. Morin A. Renouard I. Rocher J.-P. Tillement 《European journal of clinical pharmacology》1988,34(4):381-385
Summary The serum concentrations of 1-acid glycoprotein (AAG), albumin (HSA) and non-esterified fatty acids, and the serum binding of tertatolol were measured in four groups of individuals: healthy control subjects (n=24), and patients with inflammation (n=28), and hepatic (n=20) and renal (n=27) insufficiency.Serum binding of tertatolol was increased in patients with inflammation (94.6%), decreased in patients with hepatic insufficiency (88.8%) and it was unchanged in patients with renal insufficiency (92.8%) as compared to controls (92.7%).Multivariate analysis indicated that the changes were mainly related to concomitant changes in AAG concentration, which could account for 57% of intersubject variability in the bound/free ratio, and to a lesser extent in HSA, which accounted for only 4% of the variability in the binding.The data show that the free fraction of the basic drug tertatolol in serum is affected by pathological conditions that cause changes in AAG concentration. 相似文献
19.
目的分析白内障伴青光眼患者术后胰岛素抵抗及炎症因子水平变化与视觉质量的关系。 方法选取47例(47眼)白内障伴青光眼患者为研究对象,均接受超声乳化+小梁切除术治疗。术前、术后7天、术后3个月检测患者客观散射指数(OSI)、点扩散函数(PSF)、调制传递函数截止频率(MTF cutoff)、胰岛素敏感指数及白细胞介素(IL)-1β、IL-10、IL-2水平。采用Pearson法分析视觉质量参数与胰岛素抵抗情况及炎症因子的相关性。 结果与术前比较,术后7天和术后3个月最佳校正视力、MTF cutoff及胰岛素敏感指数升高,且术后3个月更高(P<0.05);与术前比较,术后7天和术后3个月眼压、角膜内皮细胞计数、PSF、OSI及血清IL-1β、IL-2、IL-10水平降低,且术后3个月更低(P<0.05)。Pearson分析显示,术前、术后7天和术后3个月,白内障伴青光眼患者OSI与胰岛素敏感指数呈负相关(P<0.05),与血清IL-1β、IL-2、IL-10水平呈正相关(P<0.05);MTF cutoff与胰岛素敏感指数呈正相关(P<0.05),与血清IL-1β、IL-2、IL-10水平呈负相关(P<0.05);PSF与血清IL-1β水平呈负相关(P<0.05)。术后7天和3个月,PSF与胰岛素敏感指数呈正相关(P<0.05),与血清IL-2、IL-10水平呈负相关(P<0.05)。 结论超声乳化联合小梁切除术对视觉质量的改善可能与胰岛素抵抗及炎症因子变化密切相关。 相似文献
20.
特发性炎性肌病(IIM)是一组与免疫失调有关的疾病,包括细胞免疫和体液免疫的异常.主要的治疗药物是精皮质激素和免疫抑制剂.对于难治性病例,现有的药物常常无效,这就需要针对IIM的发病机制开发新型的治疗药物.文中就特发性炎症性肌病的药物治疗进行综述,并且阐述了治疗效果的评估标准,讨论了药物治疗中存在的问题和今后的研究方向. 相似文献