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31.
Hodaka Fukazawa Hidehiko Kawabata Yoshito Matsui 《Journal of children's orthopaedics》2009,3(4):277-282
Purpose To describe three cases of mirror foot and to develop a new classification of the mirror feet with an emphasis on their treatment.
Methods Surgical treatment was performed on three patients with mirror foot. Mirror feet in the English literature were surveyed and
cases found in PubMed as well as our three cases were classified according to a new classification that was an analogy of
the mirror hand classification proposed by Al-Qattan et al. (J Hand Surg Br 23:534–536, 1998).
Results All three cases obtained satisfactory outcome after the treatment. In addition to these cases, 28 mirror feet were well described
in the English literature, among which only seven cases have been documented for their treatment. All of the cases could be
assigned to one of the categories of the proposed classification.
Conclusion Mirror foot is a very rare congenital deformity of the foot. We successfully treated three novel cases of mirror feet. A classification
of the mirror feet proposed in this article was useful in order to understand its nature and obtain a guideline for its treatment. 相似文献
32.
目的观察刺五加注射液及抗凝剂(潘生丁、肠溶阿斯匹林)对糖尿病足早期干预治疗的影响。方法将符合1999年WHO诊断标准的100例糖尿病合并早期足病变的患者分为两组:干预治疗组50例,对照组50例。在控制血糖、血压、糖尿病教育的基础上,干预组予以静滴刺五加注射液及口服抗凝剂(潘生丁、肠溶阿斯匹林)治疗,对照组为口服VitB1、VitB6、复方丹参片治疗。观察治疗前后两组患者足背动脉搏动、皮肤颜色、温度,痛、温、触觉等相关指征,血糖、HbA1c、血TG、TC、HDL-C,及血流变学、眼底病变、心脑血管事件发生率等。结果干预组糖尿病足病变治疗好转率高,恶化发展率低,心脑血管事件发生率少。血脂、血流变学、下肢血管多普勒彩超及眼底病变等好转改善明显,与对照组比较差异有统计学意义(P<0.05或P<0.01)。结论刺五加注射液及抗凝剂(潘生丁、肠溶阿斯匹林)对糖尿病足病变的早期干预治疗疗效显著,有重要的临床意义。 相似文献
33.
34.
成年人马蹄内翻足的分型与外科治疗 总被引:3,自引:2,他引:1
1984~1995年共收治各种马蹄内翻足1074例,18岁以上的成年人491例,术后获得1年以上随访者296例,男173例,女123例。年龄最小18岁,最大61岁,平均27.8岁。其中>45岁者9例。左下肢139例,右下肢120例,双下肢37例,共333个足。导致马蹄内翻足的病因14种,其中小儿麻痹后遗症175例,占59.1%。333个足共施行369人次手术,30例畸形严重者分两期手术矫正。6例因术后畸形矫正不足,关节融合不好又施行了二次手术。术后随访1年~8年9个月,平均3.5年,优321个足,占96.4%。差12个足。 相似文献
35.
Alexandros Zafiropoulos Eva Andersson Elias Krambovitis Carl A. K. Borrebaeck 《Journal of immunological methods》1997,200(1-2):181-190
The use of in vitro immunization technology for the generation of human antigen-specific antibodies has essentially resulted in low affinity IgM antibodies, resembling an in vivo primary immune response. We now describe a detailed reproducible protocol for a two-step in vitro immunization, which yields isotype switched, antigen-specific human antibodies. The immunizing antigen was a 30aa synthetic peptide, containing both a B (15aa V3 peptide of the HIV-1) and a T helper cell epitope (15aa peptide from tetanus toxin). The immunization protocol includes: (i) a selection procedure of donors with a memory T cell response against tetatus toxoid; (ii) immunization of mature naive peripheral B lymphocytes in two distinct phases, involving a primary and a secondary step. None of the donors which were examined after primary 7immunization showed at any time an IgG anti-V3 specific antibody response, while all the donors showed an IgM response. After the secondary immunization step, anti-V3 antibodies of both IgM and IgG isotypes were detected. The switch frequency event was high among the tested donors (5/8). 相似文献
36.
37.
38.
Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome 总被引:7,自引:0,他引:7
Minegishi Y Lavoie A Cunningham-Rundles C Bédard PM Hébert J Côté L Dan K Sedlak D Buckley RH Fischer A Durandy A Conley ME 《Clinical immunology (Orlando, Fla.)》2000,97(3):203-210
Recent studies have shown that mutations in a newly described RNA editing enzyme, activation-induced cytidine deaminase (AID), can cause an autosomal recessive form of hyper IgM syndrome. To determine the relative frequency of mutations in AID, we evaluated a group of 27 patients with hyper IgM syndrome who did not have defects in CD40 ligand and 23 patients with common variable immunodeficiency. Three different mutations in AID were identified in 18 patients with hyper IgM syndrome, including 14 French Canadians, 2 Lumbee Indians, and a brother and sister from Okinawa. No mutations were found in the remaining 32 patients. In the group of patients with hyper IgM syndrome, the patients with mutations in AID were older at the age of diagnosis, were more likely to have positive isohemagglutinins, and were less likely to have anemia, neutropenia, or thrombocytopenia. Lymphoid hyperplasia was seen in patients with hyper IgM syndrome and normal AID as well as the patients with hyper IgM syndrome and defects in AID. 相似文献
39.
Kyoko Hayashi 《Journal of medical virology》1995,47(4):323-329
Before completion of polarization, Madin-Darby canine kidney (MDCK) cells showed high infectivity and progeny production of herpes simplex virus type 1 infection. After polarization or formation of tight junctions, the infectivity and virus replication in MDCK cells was restricted significantly. The disruption of tight junctions by depletion of Ca2+ resulted in increasing virus infectivity and productivity. Mechanical disruption of tight junctions by scratching the cell monolayers with injection needle allowed markedly the replication of HSV-I in the cells aligned along the injured area. In polarized MDCK cells the progeny were released preferentially from the apical surface of the cells. These data suggest that because polarized MDCK cells mimic the epithelial cell layers, this cell line is helpful for determining the factors which regulate viral transmission in the human body. © Wiley-Liss, Inc. 相似文献
40.
Imai K Zhu Y Revy P Morio T Mizutani S Fischer A Nonoyama S Durandy A 《Clinical immunology (Orlando, Fla.)》2005,115(3):277-285
Autosomal recessive form of hyper-IgM syndrome type 2 (AR-HIGM2) is secondary to mutations affecting both alleles of AICDA gene encoding activation-induced cytidine deaminase, characterized by defects of immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) in most of the patients. We herein report the immunological phenotype of seven patients carrying a single heterozygous R190X mutation in AICDA. Variable defect in in vivo CSR inherited as an autosomal dominant (AD) trait strongly suggests that this heterozygous AICDA mutation causes HIGM (AD-HIGM2). In AD-HIGM2 B cells, CSR was consistently found impaired in vitro. However, in contrast to AR-HIGM2, the CSR-induced double-stranded DNA breaks in the switch region of IgM heavy chain gene were detected. The SHM frequency in V regions of IgM heavy chain gene in B cells was normal in all (but one patient). The characteristics of the AD-HIGM2 phenotype indicate that the AID C-terminal region may be involved in DNA repair machinery required for CSR. 相似文献