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111.
目的观察C5a/C5aR通路对约氏疟原虫17XL(P.y17XL)的增殖及其对BALB/c小鼠致死率的影响。结论将实验小鼠分为正常BALB/c组和C5aR-/-BALB/c组,每组5只,相同剂量的P.y17XL(2×105)分别感染正常BALB/c组小鼠和C5aR-/-BALB/c组小鼠,于感染后0、2、4和6d观察两组小鼠原虫血症和存活率的变化,并且采用ELISA检测感染P.y17XLBALB/c小鼠血清中C5a的水平。结果与正常组小鼠相比,C5aR-/-组小鼠生存期缩短,P.y17XL在C5aR-/-组小鼠的原虫血症较野生株小鼠高(P〈0.05),而P.y17XL感染小鼠的血清中C5a含量低于未感染的小鼠。结论 C5a/C5aR能够抑制P.y17XL的增殖,并能延长感染小鼠的生存期。 相似文献
112.
Sykes I 《Medical history》2011,55(4):479-502
This essay explores new models of the citizen-patient by attending to the post-Revolutionary blind 'voice'. Voice, in both a literal and figurative sense, was central to the way in which members of the Hospice des Quinze-Vingts, an institution for the blind and partially sighted, interacted with those in the community. Musical voices had been used by members to collect alms and to project the particular spiritual principle of their institution since its foundation in the thirteenth century. At the time of the Revolution, the Quinze-Vingts voice was understood by some political authorities as an exemplary call of humanity. Yet many others perceived it as deeply threatening. After 1800, productive dialogue between those in political control and Quinze-Vingts blind members broke down. Authorities attempted to silence the voice of members through the control of blind musicians and institutional management. The Quinze-Vingts blind continued to reassert their voices until around 1850, providing a powerful form of resistance to political control. The blind 'voice' ultimately recognised the right of the citizen-patient to dialogue with their political carers. 相似文献
113.
José Carlos Manuel-Palazuelos Joaquín Alonso-Martín María José Fernández Díaz Santiago Revuelta-Álvarez Manuel Gómez-Fleitas 《Cirugía espa?ola》2009,85(2):84-91
Introduction
The rapid development of laparoscopic surgery makes resident training programmes necessary.Objective
To analyse the results of a structured programme of laparoscopic training in an experimental laboratory.Material and method
From 2003 until 2007, we trained 11 general surgery residents for 20 h every 3 months, for three years. The practice consisted of suture and anastomosis in Endo-Trainer with animal organs, as well as laparoscopic techniques in live animals. In the Endo-Trainer practice we evaluated the time and quality of anastomosis performance. In laparoscopic techniques (cholecystectomy and anti-reflux surgery) a task table was evaluated, from 0 (no errors) to 100 (severe lesion).Results
In total, 314 anastomosis were performed by the 11 residents, with a median of 28.5 per resident (24-42). The mean time for the first gastro-jejunal anastomosis was 135 min (100-140) and 65 min (57.5-105) for the first jejunal-jejunal anastomosis. Maximum learning was achieved after 45 training hours. There wer no appreciable ifferences between both types of anastomosis. There was inadequate anastomosis quality due to leakage in 17.1% during the learning period and 13.7% during the consolidation period. In the animal, 172 procedures were performed. In cholecystectomy and anti-reflux surgery the mean scores were 2.4 and 5.6 points, respectively. In the remaining procedures, subjectively evaluated by the monitors, the quality was adequate in 65%, deficient in 22% and highly deficient in 13%.Conclusions
This structured programme of laparoscopic skills based on intestinal anastomosis allows for quicker resident training. 相似文献114.
目的探讨穴位埋线配合中频电疗治疗慢传输型便秘的疗效及机理。方法将62例慢传输型便秘的患者随机分为穴位埋线配合中频电疗观察组34例,口服麻仁软胶囊对照组28例,观察临床症状及腰骶椎检查阳性体征的变化及临床疗效对比。结果观察组疗效明显优于对照组,临床症状积分改变及腰骶椎阳性体征的变化有非常显著意义(P〈0.05)。结论穴位埋线配合中频电疗治疗慢传输型便秘是一种疗效显著、操作简便、容易接受的治疗手段,值得推广应用。 相似文献
115.
116.
Heliopsis longipes (Compositae) is a Mexican plant used as analgesic in pain toothache. A solution of 10mug/ml of dichloromethane extract from this plant showed analgesic activity determined by means of GABA release in mice brain slices. Through a bioassay-directed separation, fractions G-1, G-2, G-4 and G-6 at the same concentration were active. Affinin was the unique and common active compound, and evoke the GABA release 0.5min after administration at 1x10(-4)M concentration. Inactive compound were undeca-2E-en-8,10-dyinoic acid isobutylamide, hinokinin, 2'-hydroxyhinokinin, 3beta-sn-glyceroyl-(1'-palmitoxy)urs-12-ene, 13(18)-ursen-3beta-ol, 13(18)-ursen-3beta-acetate, beta-sitosterol and stigmasterol. The analgesic activity of Heliopsis longipes could be associated to affinin. 相似文献
117.
己糖激酶在原代培养腹膜间皮细胞的表达 总被引:3,自引:1,他引:2
目的 :探讨大鼠腹膜间皮细胞 (peritonealmesothelialcell,PMC)的原代培养方法及其己糖激酶 (hexoki nase ,HK)的表达。方法 :胰蛋白酶 EDTA消化法进行PMC的分离、培养 ,6 磷酸葡萄糖脱氢酶 (G6PDH)偶联比色法检测其HK总活性。结果 :PMC的原代及传代细胞 5~ 8d即可达到融合 ,其HK的基础活性为 (4.80± 0 .39)U/g蛋白。结论 :改良的胰蛋白酶消化法是进行PMC原代培养的一种可靠的实验方法。PMC有较强的HK活性 ,参与了腹膜透析时对葡萄糖吸收和利用方面的调节 ,可能对透析超滤有较大的影响 相似文献
118.
Ester Teixidó-Compañó Albert Espelt Luis Sordo María J. Bravo Ana Sarasa-Renedo B. Iciar Indave Marina Bosque-Prous M. Teresa Brugal 《Gaceta sanitaria / S.E.S.P.A.S》2018,32(1):41-47
Objective
To determine differences between men and women in hazardous drinking, heavy cannabis use and hypnosedative use according to educational level and employment status in the economically active population in Spain.Method
Cross-sectional study with data from 2013 Spanish Household Survey on Alcohol and Drugs on individuals aged 25-64 [n = 14,113 (women = 6,171; men = 7,942)]. Dependent variables were hazardous drinking, heavy cannabis use and hypnosedative consumption; the main independent variables were educational level and employment situation. Associations between dependent and independent variables were calculated with Poisson regression models with robust variance. All analyses were stratified by sex.Results
Hazardous drinking and heavy cannabis use were higher in men, while women consumed more hypnosedatives. The lower the educational level, the greater the gender differences in the prevalence of this substances owing to different consumption patterns in men and women. While men with a lower educational level were higher hazardous drinkers [RII = 2.57 (95%CI: 1.75-3.78)] and heavy cannabis users [RII = 3.03 (95%CI: 1.88-4.89)] compared to higher educational level, in women the prevalence was the same. Women with a lower education level and men with a higher education level had higher hypnosedative consumption. Unemployment was associated with increased heavy cannabis use and hypnosedative use in both women and men and with lower hazardous drinking only in women.Conclusions
There are differences between men and women in the use of psychoactive substances that can be explained by the unequal distribution of substance use in them according to educational level. Unemployment was associated with substance use in both men and women. 相似文献119.
Borja Ribed-Sánchez Cristina González-Gaya Sara Varea-Díaz Carlos Corbacho-Fabregat Isabel Bule-Farto Jaime Pérez de-Oteyza 《Gaceta sanitaria / S.E.S.P.A.S》2018,32(3):269-274