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91.
92.
胫骨外侧髁骨折塌陷对关节轴线及接触压力的影响 总被引:1,自引:0,他引:1
目的:研究在胫骨外侧髁骨折中关节面塌陷和外侧半月板切除对膝关节轴线、接触面积及压力的影响。方法:6个新鲜尸体膝关节标本制成胫骨外侧髁劈裂骨折模型,通过使用支撑垫片制成关节面塌陷0、1、2、4和6mm。膝关节在屈膝0°,负荷500N和屈膝30°,负荷350N。通过数码相机记录关节轴线的变化;而关节内外间隙的压力和压力扩散则由F-Scan感应器记录。每个标本在保留和切除外侧半月板下进行测试。结果:随着关节面塌陷高度的增加,膝关节外翻角度、外侧间隙的平均和最大的接触压力逐渐增加,而接触面积则逐渐减少。在屈膝0°,关节面塌陷6mm时,外翻角度平均增加7.6°,平均接触压力和最大接触压力分别增加208%和97%;而接触面积则减少33%。在同一关节面塌陷高度,切除半月板平均增加38%的外翻角度和外侧间隙45%的接触压力;而接触面积则减少26%。结论:研究结果表明在治疗胫骨外髁劈裂骨折中,减少关节面的塌陷十分重要,特别是在需切除半月板的时候。 相似文献
93.
Allergic airway inflammation induces tachykinin peptides expression in vagal sensory neurons innervating mouse airways 总被引:2,自引:0,他引:2
Q. T. Dinh † E. Mingomataj† D. Quarcoo‡ D. A. Groneberg† C. Witt§ B. F. Klapp A. Braun¶ A. Fischer† 《Clinical and experimental allergy》2005,35(6):820-825
BACKGROUND: Allergic airway inflammation has been shown to induce pro-inflammatory neuropeptides such as tachykinin peptides substance P (SP) and neurokinin A (NKA) together with related peptide like calcitonin gene-related peptide (CGRP) in nodose sensory neurons innervating guinea-pig airways. OBJECTIVE: The present study was designed to examine the effects of allergen sensitization and challenge on the SP/NKA expression in the jugular-nodose ganglion neurons innervating the murine airways. METHODS: Using retrograde neuronal tracing technique in combination with double-labelling immunohistochemistry, the expression of SP/NKA was investigated in a murine model of allergic airway inflammation. RESULTS: Allergic airway inflammation was found to induce the expression of SP/NKA (13.2+/-1.43% vs. 5.8+/-0.37%, P<0.01) in large-diameter (>20 microm) vagal sensory neurons retrograde labelled with Fast blue dye from the main stem bronchi. CONCLUSION: Based on the induction of tachykinins in airway-specific large-sized jugular-nodose ganglia neurons by allergic airway inflammation, the present study suggests that allergen sensitization and challenge may lead to de novo induction of tachykinins in neurons. This may partly contribute to the pathogenesis of airways diseases such as allergic airway inflammation. 相似文献
94.
95.
猫阴部神经传入传出成分在脊髓内的定位分布—HRP逆行及跨越神经节追踪研究 总被引:1,自引:1,他引:1
向猫阴部神经及其分支注入HRP溶液,观察并分析了逆行和跨节追踪的结果。 1.证实阴部神经为含躯体传出、传入,内脏传出、传入纤维的混合神经,其内脏性传出、传入成分仅存在于阴茎背神经中。 2.逆行标记细胞出现于L_7—S_3前角Onuf核和S_(1-3)的中间带外侧核。本文结果表明,Onuf核是支配盆底横纹肌的运动核,但它和其它前角运动核在细胞形态和活性物质的分布上都明显不同。特别是它的一部分神经元的树突形成树突束到达中间带外侧核。本文结合排尿、排便功能从形态学上较详细地讨论了Onuf核和中间带外侧核的关系。 3.本文证明阴部神经领域的内脏初级传入(来自阴茎背神经)和躯体初级传入纤维都向骶髓后连合核区有浓密的投射。结合以往的工作讨论了盆腔脏器、外生殖器的内脏传入和坐骨神经、阴部神经的躯体传入在骶髓后连合核区汇聚的现象及机能意义,推测这种汇聚可能是产生牵涉痛和针刺镇痛机制的形态学基础。 相似文献
96.
本文作者研究了膀胱(内脏)及坐骨神经(躯体)初级传入纤维向脊髓的投射。发现内脏传入纤维和躯体本体觉粗纤维都向S_2—S_4节段后连合核区投射,两者的投射区有重叠。推测内脏传入和躯体本体觉传入的纤维在后连合核可能有汇聚。另外,根据躯体本体党纤维在髓内跨节段分布的范围和位置以及盆腔脏器初级传入的投射位置,结合文献分析和讨论了脊髓后连合核的位置和形态。提出在脊髓内存在着一个和脑部的孤束核在形态及功能上酷似的脊髓后连合核的见解。它在吻侧以对称的狭细细胞带起于胸髓下段,向尾侧逐渐扩大位于Ⅵ层内侧部,到骶髓成为位于中央管背外方的核团,S_3以下两侧者合并形成位于中央管背侧后连合区的较大核团,一直可追踪到尾髓。 相似文献
97.
成年大鼠基底前脑隔-斜角带复合体的巢蛋白免疫阳性神经元至海马的纤维投射 总被引:3,自引:0,他引:3
目的 观察大鼠基底前脑巢蛋白(nestin)免疫阳性神经元的纤维投射。方法 先用荧光素逆行追踪法显示基底前脑内投射至海马的荧光素标记神经元,观察摄片后再进行nestin免疫组织化学染色。对比荧光照片和免疫组织化学染色照片,辨认荧光素和nestin双标神经元。结果 在基底前脑注射侧的内侧隔核(MS)和斜角带核的垂直支(vDB)和水平支(hDB)均存在荧光素标记细胞,其中一部分为nestin免疫阳性。在MS、vDB和hDB,双标细胞占逆行标记细胞的比例分别为21.3%、25%和20.6%;占nestin阳性细胞的比例分别为26.6%、15.7%和16.3%。结论 大鼠基底前脑的nestin免疫阳性神经元发出神经纤维向海马投射。提示在基底前脑有一个平行于隔-海马胆碱能投射和GABA能投射的第3条通路。 相似文献
98.
用荧光金逆行束路追踪结合免疫荧光双标记技术及HRP逆行束路追踪结合免疫细胞化学双标记技术证明,在大鼠终纹床核投射至结合臂旁核的神经元中,位于前外侧区卵圆核及其腹侧邻近区中的部分为神经降压肽及促肾上腺皮质激素释放因子免疫反应阳性,双标记细胞分别约占这个部位逆行标记细胞总数的40%及20%;在前腹侧区的梭形核及大细胞核中,部分为促肾上腺皮质激素释放因子免疫反应阳性。 相似文献
99.
Shirley L. Buchanan Richard H. Thompson Brian L. Maxwell D. A. Powell 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1994,100(3):469-483
The different cytoarchitectonic regions of the medial prefrontal cortex (mPFC) have recently been shown to play divergent
roles in associative learning in rabbits. To determine if these subareas of the mPFC, including areas 24 (anterior cingulate
cortex), 25 (infralimbic cortex), and 32 (prelimbic cortex) have differential efferent connections with other cortical and
subcortical areas in the rabbit, anterograde and retrograde tracing experiments were performed using thePhaseolus vulgaris leukoagglutinin (PHA-L), and horseradish peroxidase (HRP) techniques. All three areas showed local dorsal-ventral projections
into each of the other areas, and a contralateral projection to the homologous area on the other side of the brain. All three
also revealed a trajectory through the striatum, resulting in heavy innervation of the caudate nucleus, the claustrum, and
a lighter projection to the agranular insular cortex. The thalamic projections of areas 24 and 32 were similar, but not identical,
with projections to the mediodorsal nucleus (MD) and all of the midline nuclei. However, the primary thalamic projections
from area 25 were to the intralaminar and midline nuclei. All three areas also projected to the ventromedial and to a lesser
extent to the ventral posterior thalamic nuclei. Projections were also observed in the lateral hypothalamus, in an area just
lateral to the descending limb of the fornix. Amygdala projections from areas 32 and 24 were primarily to the lateral, basolateral
and basomedial nuclei, but area 25 also projected to the central nucleus. All three areas also showed projections to the midbrain
periaqueductal central gray, median raphe nucleus, ventral tegmental area, substantia nigra, locus coeruleus and pontine nuclei.
However, only areas 24 and the more dorsal portions of area 32 projected to the superior colliculus. Area 25 and the ventral
portions of area 32 also showed a bilateral projection to the parabrachial nuclei and dorsal and ventral medulla. The dorsal
portions of area 32, and all of area 24 were, however, devoid of these projections. It is suggested that these differential
projections are responsible for the diverse roles that the cytoarchitectonic subfields of the mPFC have been demonstrated
to play in associative learning. 相似文献
100.
J. Cornwall J. D. Cooper O. T. Phillipson 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1990,80(1):157-171
Summary Afferent pathways to the rostral reticular thalamic nucleus (Rt) in the rat were studied using anterograde and retrograde lectin tracing techniques, with sensitive immunocytochemical methods. The analysis was carried out to further investigate previously described subregions of the reticular thalamic nucleus, which are related to subdivisions of the dorsal thalamus, in the paraventricular and midline nuclei and three segments of the mediodorsal thalamic nucleus. Cortical inputs to the rostral reticular nucleus were found from lamina VI of cingulate, orbital and infralimbic cortex. These projected with a clear topography to lateral, intermediate and medial reticular nucleus respectively. Thalamic inputs were found from lateral and central segments of the mediodorsal nucleus to the lateral and intermediate rostral reticular nucleus respectively and heavy paraventricular thalamic inputs were found to the medial reticular nucleus. In the basal forebrain, afferents were found from the vertical and horizontal limbs of the diagonal band, substantia innominata, ventral pallidum and medial globus pallidus. Brainstem projections were identified from ventrolateral periaqueductal grey and adjacent sites in the mesencephalic reticular formation, laterodorsal tegmental nucleus, pedunculopontine nucleus, medial pretectum and ventral tegmental area. The results suggest a general similarity in the organisation of some brainstem Rt afferents in rat and cat, but also show previously unsuspected inputs. Furthermore, there appear to be at least two functional subdivisions of rostral Rt which is reflected by their connections with cortex and thalamus. The studies also extend recent findings that the ventral striatum, via inputs from the paraventricular thalamic nucleus, is included in the circuitry of the rostral Rt, providing further evidence that basal ganglia may function in concert with Rt. Evidence is also outlined with regard to the possibility that rostral Rt plays a significant role in visuomotor functions.Abbreviations ac
anterior commissure
- aca
anterior commissure, anterior
- Acb
accumbens nucleus
- AI
agranular insular cortex
- AM
anteromedial thalamic nucleus
- AV
anteroventral thalamic nucleus
- BST
bed nucleus of stria terminalis
- Cg
cingulate cortex
- CG
central gray
- CL
centrolateral thalamic nucleus
- CM
central medial thalamic nucleus
- CPu
caudate putamen
- DR
dorsal raphe nucleus
- DTg
dorsal tegmental nucleus
- EP
entopeduncular nucleus
- f
fornix
- Fr2
Frontal cortex, area 2
- G
gelatinosus thalamic nucleus
- GP
globus pallidus
- Hb
habenula
- HDB
horizontal limb of diagonal band
- IAM
interanterodorsal thalamic nucleus
- ic
internal capsule
- INC
interstitial nucleus of Cajal
- IF
interfascicular nucleus
- IL
infralimbic cortex
- IP
interpeduncular nucleus
- LC
locus coeruleus
- LDTg
laterodorsal tegmental nucleus
- LH
lateral hypothalamus
- LHb
lateral habenular nucleus
- ll
lateral lemniscus
- LO
lateral orbital cortex
- LPB
lateral parabrachial nucleus
- MD
mediodorsal thalamic nucleus
- MDL
mediodorsal thalamic nucleus, lateral segment
- Me5
mesencephalic trigeminal nucleus
- MHb
medial habenular nucleus
- mlf
medial longitudinal fasciculus
- MnR
median raphe nucleus
- MO
medial orbital cortex
- mt
mammillothalamic tract
- OPT
olivary pretectal nucleus
- pc
posterior commissure
- PC
paracentral thalamic nucleus
- PF
parafascicular thalamic nucleus
- PPTg
pedunculopontine tegmental nucleus
- PrC
precommissural nucleus
- PT
paratenial thalamic nucleus
- PV
paraventricular thalamic nucleus
- PVA
paraventricular thalamic nucleus, anterior
- R
red nucleus
- Re
reuniens thalamic nucleus
- RRF
retrorubral field
- Rt
reticular thalamic nucleus
- Scp
superior cerebellar peduncle
- SI
substantia innominata
- sm
stria medullaris
- SNR
substantia nigra, reticular
- st
stria terminalis
- TT
tenia tecta
- VL
ventrolateral thalamic nucleus
- VO
ventral orbital cortex
- VP
ventral pallidum
- VPL
ventral posterolateral thalamic nucleus
- VTA
ventral tegmental area
- 3
oculomotor nucleus
- 3V
3rd ventricle
- 4
trochlear nucleus 相似文献