Recombinant human granulocyte-macrophage colony-stimulating factor hydrogel promotes healing of deep partial thickness burn wounds

Objective

To assess the effects of recombinant human granulocyte/macrophage colony-stimulating factor (rhGM-CSF) hydrogel on the healing of deep partial thickness burn wounds.

Methods

Ninety three wounds of 65 burn patients who suffered from a deep partial thickness burn of <5% TBSA and could not heal over 3 weeks were included in this study. The patients were randomly assigned to use rhGM-CSF hydrogel (GC group, n = 32) or hydrogel without rhGM-CSF (control group, n = 33). rhGM-CSF hydrogel or hydrogel without rhGM-CSF was topically applied to the wounds, the dressing was changed once a day. Wound healing time and percentage, wound discharge, periwound inflammation, the positive wound swabs culture count, and adverse drug reactions were observed and compared between two groups.

Results

Healing time was 12.2 ± 5.0 days after the application of rhGM-CSF hydrogel. This was significantly shorter than that of control wounds (15.5 ± 4.7 days). Healing percentage at 14 days in the rhGM-CSF-treated wounds was 97.5 ± 7.7%, which was markedly higher than the control (85.9 ± 6.8%). At 3, 6, 12, 14 day, the GC group was significantly superior to the control group with respect to the score of periwound inflammation, wound purulence and discharge. The positive wound swabs culture count of the GC group on the 7th and 14th day post-treatment was 14 and 4, respectively, which was significantly lower than the control.

Conclusion

rhGM-CSF hydrogel promotes the healing process of deep partial thickness burns effectively. No adverse reaction of the drug was observed during the study.     

重组人表皮生长因子与复合溶菌酶联合治疗儿童烧伤创面的效果研究

目的:观察重组人表皮生长因子与复合溶菌酶联合治疗儿童烧伤创面的临床效果,为临床治疗儿童烧伤提供一种新的治疗方法。方法:将80例儿童烧伤患者采用自身对照选择相同深度的两个创面随机分为治疗组与对照组进行研究治疗。治疗组给予重组人表皮生长因子与复合溶菌酶联合治疗;对照组给予硝酸银软膏治疗。临床观察创面愈合时间、创面炎症反应发生情况、创面细菌培养情况、过敏反应、创面愈合3个月后期随访有无色素沉着或脱失、瘢痕增生的情况。结果:治疗组比对照组创面愈合时间明显缩短,减少创面炎症反应及感染机会,治疗组明显优于对照组(P<0.05);患者未出现过敏反应和其它不良反应,后期随访瘢痕增生少。结论:重组人表皮生长因子与复合溶菌酶联合治疗儿童烧伤创面,明显缩短创面愈合时间,减轻创面炎症反应,疗效可靠。在今后儿童烧伤创面治疗中具有广阔的临床发展前景,适用于基层医院使用。     

综合心理干预在颜面部烧伤患者治疗中的应用

目的:通过对颜面部烧伤患者的综合心理干预,探讨颜面部烧伤患者心理健康状况及对生活能力的影响,评估综合心理干预在颜面部烧伤患者临床疗效中的重要作用。方法:将95例患者随机分为实验组和对照组。实验组在实施常规医学护理的同时给予各类综合心理干预措施。干预前后均采用抑郁自评量表、焦虑自评量表、症状自评量表和Bart hel指数记分法对患者心理状况及生活能力进行评定。结果:综合心理干预后,实验组SDS评分、SAS评分均明显低于对照组,实验组抑郁、焦虑、恐怖、精神病性因子评分等也明显低于对照组。结论:在颜面部烧伤患者的临床治疗中,综合心理干预能够更好的改善患者的焦虑、抑郁、心理健康状况、生活自理能力。对颜面烧伤患者实施综合心理干预,在其整个治疗中非常必要且具有重要意义。     

背部供皮区在大面积烧伤后期整复中的应用

目的探讨背部供皮区应用于大面积烧伤后期整复中的优势。方法对52例大面积烧伤后期整复患者,采用鼓式取皮机在背部切取中厚皮片,移植修复多处瘢痕切除创面,观察供、植皮区愈合情况。结果52例患者术后随访1～2年,移植皮片均成活,质地柔软、平整光滑,富有弹性,无明显增生性瘢痕,关节区活动自如,功能和外观恢复良好。供皮区愈合良好,无瘢痕增生或增生轻微。结论背部供皮区可多次切取中厚皮片,用于大面积皮肤瘢痕创面的修复,手术效果良好,是大面积烧伤后期整复中的理想供区。     

应用益生菌制剂对严重烧伤患者炎症反应的影响

［摘要］ 目的观察应用益生菌制剂对严重烧伤者血常规、血浆蛋白的影响,探讨益生菌制剂在减轻烧伤炎症反应中的疗效和价值。 方法将88例烧伤患者根据是否应用益生菌制剂（双歧杆菌活菌胶囊）分为干预组33例和对照组55例。干预组给予双歧杆菌活菌胶囊口服14 d,2组烧伤常规治疗一致。记录2组应用前与应用14 d后的血常规和血浆蛋白,并进行统计学分析。 结果应用益生菌制剂14 d后2组白细胞计数、中性粒细胞百分数、淋巴细胞计数均低于用药前,2组淋巴细胞百分数均高于用药前,对照组单核细胞计数和干预组血小板计数均低于用药前,干预组单核细胞计数高于用药前,差异有统计学意义（P＜0.05）。用药后,干预组白细胞计数、中性粒细胞百分数、淋巴细胞百分数和血小板计数均低于对照组,单核细胞计数高于对照组,差异有统计学意义（P＜0.05）。用药后,干预组白蛋白低于用药前,总蛋白高于用药前,差异均有统计学意义（P＜0.05）。用药后,干预组白蛋白高于对照组,差异有统计学意义（P＜0.05）。 结论临床应用益生菌制剂能减轻烧伤后的炎症反应和机体的损伤。     

病例引导的PBL教学模式在烧伤外科临床见习中的应用探讨

以问题为导向的(Problem based learning,PBL)教学法在国内外高等医学教育中应用广泛并进行了不断改良。我们通过建立典型病例的资料库,逐步将病例引导的PBL教学模式应用于烧伤外科的临床见习教学中,强调以学生为中心,充分调动学生的主观能动性,着眼于学生形成正确的临床思维方法和最终分析解决问题的能力,以此来提高烧伤外科见习教学的质量。     

89例下肢瘢痕癌的诊治体会

目的：总结下肢瘢痕癌的临床特点及其诊治方法。方法：回顾性分析中南大学湘雅医院烧伤重建外科 1998年1月至2017年12月收治的89例下肢瘢痕癌患者的临床资料,包括人口统计学、致伤因素、癌变潜伏期、病变部 位、溃疡面积、病理类型、骨质侵犯、淋巴结转移情况、手术方式、修复方法与预后等。结果：89例下肢瘢痕癌患 者中,男70例,女19例;最常见致伤因素依次为火焰烧伤(42例)、创伤(19例)、烫伤(12例)。病变最常见于小腿(31 例),其次为大腿(11例)、足跟(11例);溃疡面积为1.5~600.0 cm2 。其中鳞状细胞癌80例、疣状癌8例、肉瘤1例。术前 发现腹股沟淋巴结肿大78例,行腹股沟淋巴结清扫49例,单纯淋巴结活检、切除29例;9例发现淋巴结转移,8例有 骨质侵犯;24例行截肢术,53例行病灶扩大切除皮片移植术,12例行病灶扩大切除皮瓣修复术。65例得到随访,8例 出现复发,其中截肢者2例,扩大切除者6例,且肿瘤复发与手术方式无关(P>0.05)。结论：下肢瘢痕癌复发转移率较 高,需早期发现、早期诊断,应尽早手术治疗并定期随访;腹股沟淋巴结肿大较常见,需行淋巴结活检、切除或清 扫;局部扩大切除、植皮或皮瓣修复是其主要治疗方法,但癌肿较大、侵犯较深且下肢瘢痕广泛、畸形严重者可考 虑截肢。     

大剂量乌司他丁对大面积烧伤患者凝血功能的影响及意义

目的：观察大剂量乌司他丁对大面积烧伤患者凝血功能的影响。方法：4例大面积烧伤患者入院后第3天起每天给予大剂量乌司他丁(60万U,4次/d),用药前及用药后1d、3d、7d、10d、14d,抽血观察血浆纤维蛋白原含量(Fib-c)、凝血酶原时间(PT)、凝血酶时间(TT)、部分凝血活酶时间(APTT)及血浆D-二聚体含量的变化。结果：用药前血浆D-二聚体及纤维蛋白原含量明显升高,PT时间显著延长;给予大剂量乌司他丁1d后,血浆D-二聚体及纤维蛋白原含量明显减低,PT时间迅速恢复。结论：大面积烧伤患者早期应用大剂量乌司他丁可显著改善凝血功能,预防播散性血管内凝血的发生。     

Pediatric instant noodle burns: A ten-year single center retrospective study

IntroductionChildren are particularly vulnerable to scald injuries, and hot beverages/foods are often implicated in this subset of pediatric burns. Burns from instant noodles are common and thus an attractive target for burn prevention. The purpose of this study is to characterize the frequency, demographics, outcomes, and circumstances of pediatric instant noodle burns to guide future educational and prevention efforts.MethodsThis is a retrospective review of all pediatric patients (<18 years) admitted to the University of Chicago Burn Center with a diagnosis of scald injury between 2010 and 2020. Burns caused by instant noodles were identified and compared to all other scald burns over this period.ResultsAmong 790 pediatric scald burns, 245 (31.0 %) were attributed to instant noodles. Compared to other scalds, patients with instant noodle burns were older (5.4 vs. 3.8 years, p < 0.001), equally likely to be male (51 % vs. 54 %, p = 0.488), and more likely to be Black/African American (90.6 % vs. 75.2 %, p < 0.001). Patients with instant noodle burns lived in zip codes with a lower average childhood opportunity index score (9.9 vs. 14.6, p < 0.001). In terms of circumstances, children with instant noodle burns were more likely to be unsupervised at the time of injury (37 % vs 21 %, p < 0.001). Instant noodle burns were smaller (3.6 % total body surface area (TBSA) vs. 5.8 % TBSA, p < 0.001) and less likely to require operative intervention (29 % vs. 41 %, p < 0.001). Instant noodle burns had a shorter length of stay (4.2 days vs. 6.4 days, p < 0.001), but similar adjusted length of stay (1.7 days/%TBSA vs. 1.5 days/%TBSA, p = 0.18) and experienced similar complication rates (10 % vs. 15 %, p = 0.06).ConclusionInstant noodle burns comprised nearly one-third of all pediatric scald burn admissions at our institution, a higher proportion than previously reported. While less severe than other scald burns in this series, instant noodles injuries still demonstrated a need for hospitalization and operative intervention. Instant noodle burns disproportionately affected Black/African American patients, as well as from neighborhoods with lower socioeconomic status. These findings suggest that focused burn prevention efforts may be successful at reducing the incidence of these common, but serious injuries.     

针对性护理对重度烧伤伴并发症患者负性情绪及生活质量的影响

目的 分析针对性护理对重度烧伤伴并发症患者负性情绪及生活质量的影响。方法 选取邯郸钢 铁集团有限责任公司职工医院2020年6月-2022年9月收治的104例重度烧伤伴并发症患者为研究对象,依据 随机数字表法分为观察组与对照组,各52例。对照组行常规护理干预,观察组实施针对性护理干预,比较 两组负性情绪、生活质量及护理满意度。结果 两组护理后SAS、SDS评分均低于护理前,且观察组低于对 照组,差异有统计学意义（P＜0.05）;两组护理后躯体功能、社会关系、心理功能、一般健康状况评分均 高于护理前,且观察组高于对照组,差异有统计学意义（P＜0.05）;观察组护理满意度高于对照组,差异 有统计学意义（P＜0.05）。结论 对重度烧伤伴并发症发生的患者实施针对性护理干预可减轻其抑郁焦虑 情绪,提升生活质量,促进护理满意度的提高。