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51.
目的:探讨血清和支气管肺泡灌洗液(BALF)中肿瘤标志物联合检测对肺癌诊断的价值。方法:采用放射免疫分析方法对癌胚抗原(CEA)、铁蛋白(FT)和(β2-MG)进行分析。结果:肺癌患者血清及BALF中CEA、FT浓度均明显高于肺良性病变组,两组比较有显著性差异(P〈0.01或P〈0.05)。BALF中CEA、F物浓度 血清浓度,且腺癌CEA和FT浓度高于鳞癌和小细胞未分化癌。β2-MG的血清和BA 相似文献
52.
K. Gründel W. Schwenk B. Böhm J. M. Müller 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1996,381(3):160-164
Zusammenfassung In einer prospektiv randomisierten Studie wurden bei 100 Patienten mit elektiven konventionellen (n=66) oder laparoskopischen (n=34) kolorektalen Resektionen die präoperative Darmvorbereitung mit einer 2 1-Polyäthylenglykol(PEG)-haltigen Lösung plus Prepacol® (Gruppe A, n=50) und die mit einer 4 1-PEG-Lösung (Gruppe B, n=50) verglichen. Im Rahmen der Studie wurde auch der Einfluß der Art und Qualität der Darmvorbereitung auf die Dauer des postoperativen Ileus untersucht. Die Qualität der Darmvorbereitung wurde wührend der Resektion am eröffneten Darm mit einem 4-Punkte-Score durch den Chirurgen bestimmt. Das Zeitintervall vom Ende der Operation bis zum ersten postoperativen Windabgang und dem ersten Stuhlgang wurden dokumentiert. Die Qualität der Darmvorbereitung wurde in beiden Gruppen als gleich gut beurteilt (Gruppe A: 94%; Gruppe B: 84%; p=0,5). Das postoperative Intervall bis zum Abgang von Winden (A: 3,1 ± 1,2 Tage; B: 3,2 ± 13 Tage; p = 0,6) und zum ersten Stuhlgang (A: 3,9 ± 1,3 Tage; B: 4,1 ± 1,3 Tage; p=0,5) war in beiden Patientengruppen etwa gleich lang. Als einziger Faktor mit eigenständigem Einfluß auf die Dauer des postoperativen Ileus in der multivariaten Analyse (Alter, Geschlecht, Vorbereitung, Operationsdauer, Operation, Operationstechnik) wurde die Operationstechnik (laparoskopisch oder konventionell) identifiziert. Der erste Stuhlgang trat nach laparoskopischeu Resektionen bereits nach durchschnittlich 3,2±1,1 Tagen auf, nach konventionellen Operationen dagegen erst nach 4,3±1,2 Tagen (p=0,001). Die Art (41 PEG oder 21 FEG plus Prepacol®) und Qualität der Darmvorbereitung beeinflußten die Dauer der postoperativen Motilitätsstörung nicht.
Effect of bowel lavage with prepacol and polyethylene glycol on the duration of postoperative ileus following colorectal resection
In a prospective randomized study in 100 patients undergoing conventional (n=66) or laparoscopic (n=34) colorectal resection, mechanical lavage with 2 1 of a polyethylene glycol (PEG) solution (group A, n=50) combined with a laxative was compared with lavage with 4 1 of PEG alone (group B, n=50). The influence of bowel preparation on postoperative Hens was investigated. The efficacy of bowel preparation was determined intraoperatively by a surgeon blind to the type of preparation. The time interval between the end of the operation an first flatus or bowel movement was recorded. The efficacy of preparation was no different between the groups (group A: 94%, group B: 84%; P=0.5). The time lapse before first flatus (A: 3.1 ± 1.2 days, B: 3.2 ± 1.3 days; P = 0.6) or bowel movement (A: 3.9 ± 1.3 days, B: 4.1 ± 1.3 days; P = 0.5) also did not differ between the groups. The only factor found in multivariate analysis (age, sex, operation, duration and type of surgery, bowel preparation) to prolong the duration of postoperative ileus was the type of surgery. The first bowel movement occurred 3.2 ± 1.1 days after conventional surgery and 4.3±1.2 days (P<0.001) after laparoscopic surgery. The type of preoperative bowel preparation had no influence on the duration of postoperative Hens. The postoperative interval before the first bowel movement was shorter after laparoscopic surgery.相似文献
53.
中药脑肺康对地鼠实验性肺气肿及肺动脉高压的防治作用 总被引:2,自引:0,他引:2
目的 观察中药肺康对缺氧性肺动脉高压和肺气肿的防治效果并探讨其作用机制。方法 以弹性蛋白酶溶液滴注入金黄地鼠气管内,正常饲养30d后,常压下缺氧15d,分别设立中药脑肺康预防组、治疗组、肺气肿+缺氧组及正常对照组。于处死动物前,测量平均肺动脉压,取静脉血进行循环内皮细胞计数;处死后测量右心肥大指数,光镜下计数左侧肺支气管肺泡灌洗液内细胞总数,对右侧肺进行光镜图像分析。结果 中药脑肺康预防组和治疗3 相似文献
54.
Nitric oxide (NO) is produced in the upper and lower respiratory tract and can be detected in exhaled air of both healthy
individuals and subjects with pulmonary diseases. Recent studies have shown that exhaled NO is mainly derived from the upper
airways. There is, however, evidence that in aqueous solutions NO is rapidly converted to distinct oxides of nitrogen. We
therefore studied the stable NO metabolites nitrate and nitrite in broncho-alveolar lavage (BAL) fluid and serum as indicators
of NO formation in the lower respiratory tract. The study population consisted of 31 healthy children undergoing elective
surgery for nonpulmonary illnesses and 13 immunosuppressed children with pneumonia. Nitrate and nitrite were determined photometrically.
Nitrate was found in BAL fluid of all children. In children with pneumonia, nitrate concentrations in BAL fluid were significantly
higher than in healthy children. A significant correlation was observed between nitrate in BAL fluid and serum of immunosuppressed
children with pneumonia. Nitrite was not detected in any of the BAL fluid or serum samples.
Conclusions Our results suggest that in the lower airways significant amounts of NO are metabolised to nitrate. Studies on NO in pulmonary
diseases should therefore include determination of nitrate in lower airway fluids.
Received: 21 August 1996 / Accepted: 12 December 1996 相似文献
55.
目的:了解腹腔灌洗联合前列地尔对重症急性胰腺炎的疗效。方法:回顾分析内科保守治疗组(A组18例)、腹腔灌洗组(B组12例)、腹腔灌洗前列地尔联合治疗组(C组15例)三组间腹痛缓解时间、消失时间,血淀粉酶恢复正常时间,C反应蛋白(CRP)浓度变化,急性肺损伤(ALI)的发生率,死亡率的差异。结果:C组血淀粉酶恢复正常时间短于A组和B组;C组CRP浓度、ALI的发生率均低于A组和B组。腹痛缓解时间、消失时间B组和C组均短于A组(P<0.05,但B、C两组间比较差异无统计学意义。腹腔灌洗和前列地尔有降低死亡率的趋势,但3组间死亡率差异无统计学意义(P>0.05)。结论:腹腔灌洗联合前列地尔治疗重症急性胰腺炎优于单纯的保守治疗和腹腔灌洗。 相似文献
56.
57.
58.
Stamatis Karakonstantis Emmanouil Tzagkarakis Dimitra Kalemaki Charalampos Lydakis Gregorios Paspatis 《Expert Review of Gastroenterology & Hepatology》2018,12(1):63-72
Introduction: The usefulness of nasogastric aspiration and nasogastric lavage in patients with gastrointestinal bleeding is controversial, as evidenced by conflicting recommendations, both among and within society guidelines.Areas covered: Considering these controversies, we reviewed the evidence regarding the following questions: 1) Can nasogastric lavage stop or slow down the bleeding and improve subsequent endoscopic visualization? 2) Is nasogastric aspiration helpful for the localization of bleeding? 3) Can nasogastric aspiration identify high risk patients that might benefit from earlier endoscopy? 4) Is there evidence for benefit in terms of outcomes from using nasogastric aspiration? 5) Is nasogastric intubation safe in patients with possible esophageal varices? Our review was conducted according to PRISMA guidelines.Expert commentary: Based on the available literature, nasogastric lavage or aspiration cannot be routinely recommended unless a large properly designed randomized trial (which is currently lacking) proves otherwise. It is a painful and time-consuming procedure with no demonstrated benefit for the patient in terms of outcomes. Other clinical and laboratory parameters, and risk scores, are less invasive and are effective for guiding the stratification and management of patients, while pre-endoscopic erythromycin infusion is a good if not better alternative for improving visualization of the stomach. 相似文献
59.
Pulmonary alveolar proteinosis represents a rare syndrome characterized by the accumulation of proteinaceous phospholipid-laden material in the alveoli. This leads to impaired gas exchange and arterial hypoxemia of varying degrees. The diagnosis is confirmed by lung biopsy. Sequential whole-lung lavage (WLL) first described in 1963 is the standard of care. We report a case of a male diagnosed of having pulmonary alveolar proteinosis (PAP) on transbroncial lung biopsy (TBLB). He was treated with sequential WLL (Left followed by right, Left being more involved on chest X-ray) followed by recombinant GM-CSF, with good result. 相似文献
60.