Outcome of a multicenter treatment program including autologous or allogeneic bone marrow transplantation for de novo acute myeloid leukemia

Abstract: The results of an intensive treatment program for patients 16–60 yr of age with de novo acute myeloid leukemia are presented. The patients were given conventional induction treatment with daunorubicin and cytarabine. Patients not entering complete remission (CR) after 1 course of daunorubicin/cytarabine were given 1 course of amsacrine/etoposide/cytarabine. Those entering complete remission received 3 consolidation courses using mitoxantrone, etoposide, amsacrine and cytarabine. One hundred and eighteen patients were enrolled. Complete remission was attained after 1–2 courses in 90 patients (76%). Another 6 patients reached CR after 3–4 induction courses for a total CR rate of 81%. If feasible, patients were offered either allogeneic or unpurged autologous bone marrow transplantation. Twenty-four patients underwent allogeneic bone marrow transplantation; 15 in first remission, 8 in second remission, 1 in early relapse. Thirty patients below 56 yr of age underwent autologous bone marrow transplantation in first remission. The overall probability of survival at 4 yr was 34%, and for patients below 40 yr of age 50%. Leukemia-free survival was 35% for the whole cohort of patients; 52% for patients below 40 yr of age. Patients undergoing allogeneic or autologous bone marrow transplantation in first remission had an overall survival of 86% and 47%, respectively, while the probability of leukemia-free survival in these groups was 87% vs. 40% at 4 yr. The CR rate and long-term results of this intensive treatment program compare favorably with other recent studies using intensive consolidation with allogeneic or autologous bone marrow transplantation or high dose cytarabine.     

克隆特含漱液毒性实验研究

目的探讨克隆特会激液对实验动物的毒性反应。方法小鼠灌胃给药、大鼠局部给药，连续观察14d内动物的毒性反应；将克隆特含激浪涂数干实验动物的完整和破损皮肤上，观察局部刺激作用、皮肤过敏反应；将克隆特含激法0．1ml缓慢注入明道内，每日一次，连续1wk，观察用道粘膜组织有无充血、水肿现象。结果克隆特合漱液小鼠灌胃30ml·kg-1体重（含甲硝吐150mg）无毒性反应；局部用药量为5ml·kg-1体重（合甲硝唑25mg）亦未出现毒性反应；对皮肤及明道粘膜无明显刺激作用，亦未见皮肤过敏反应。结论克隆特合漱法局部用药较安全。     

肺移植急性排斥反应及其控制实验研究

观察了大鼠实验性肺移植术后急性排斥反应的病理改变。异系间移植术后２ｄ，移植肺内小血管及支气管周围出现单核细胞浸润。４ｄ上述细胞浸润波及肺泡壁，导致肺泡壁增厚，肺内小静脉系及毛细血管管腔变窄，血流不畅。术后６ｄ，血液循环严重障碍处，肺泡完全坏死，环抱素Ａ可使上述排斥反应得到明显抑制。     

Drug Induced Acute Generalized Exanthematous Pustulosis

A 62-year-old woman with diabetic triopathy developed widespread erythematous macules, numerous pustules, and a high fever after she underwent electric coagulation for vitreous hemorrhage. She was administered several drugs at that time. After discontinuation of the drugs, the eruption disappeared, and the fever returned to normal within two weeks. A positive patch test with isepamicin sulfate highly suggested that the symptoms described above were due to drug allergy. Cadralazine, which was positive in the drug lymphocyte stimulation test (DLST), could not be excluded from the causative drugs. A false-positive DLST with ofloxacin was confirmed by an accidental challenge test. To our knowledge, this is the first report of acute generalized exanthematous pustulosis due to isepamicin sulfate and/or cadralazine.     

The dynamic distribution of nitric oxide synthase in the small intestine of mice with intestinal radiation sickness

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Effects of Phentolamine on Hemorrheology and Hemodynamics in Dogs with Acute Liver Damage

ＥｆｆｅｃｔｓｏｆＰｈｅｎｔｏｌａｍｉｎｅｏｎＨｅｍｏｒｒｈｅｏｌｏｇｙａｎｄＨｅｍｏｄｙｎａｍｉｃｓｉｎＤｏｇｓｗｉｔｈＡｃｕｔｅＬｉｖｅｒＤａｍａｇｅＤＡＮＺｉｌｉ（但自力）；ＺＨＡＮＧＷｅｎｙｉｎｇ（张文英）；ＬＩＳｈａｏｂａｉ（李绍白）（Ｉｎ...     

急性出血坏死性胰腺炎手术治疗的临床观察

总结了经手术证实为急性出血坏死性胰腺炎的５３例患者的手术疗效。发现该病应早期手术。若发病４天后手术，体温在３８℃以上、脉搏超过１２０次／分、收缩压在１２ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ）以下、有弥漫性腹膜炎、白细胞高于１６×１０９／Ｌ和术后有重要器官功能衰竭者，术后病死率明显增高。手术方法以胰腺坏死组织清除加三造瘘、腹腔三套管持续冲洗为优。抑制胰腺分泌的药物主要选用５氟脲嘧啶。引起胰腺感染的常见病原菌依次是大肠杆菌、肺炎克雷白杆菌、肠球菌、金黄色葡萄球菌、绿脓杆菌、奇异假单胞菌、链球菌、产气肠杆菌和脆弱类杆菌９种细菌。选用抗生素应遵守３个原则：①抗生素必须能通过血胰屏障。②能在胰腺组织中形成有效的治疗浓度。③能有效地抑制引起胰腺感染的病原菌。这样，才能取得良好的治疗效果。     

家兔实验性减压病时血浆中血拴素A_2及前列环素含量的变化

实验观察了“安全”减压和不适当减压条件下家兔减压病(DCS)的发病情况、Doppler超声以及血浆中TxB_2和6-keto-PGF_(1a)的变化;还观察了消炎痛对DCS的预防怍用。结果显示:减压愈不当,DCS发病愈重,Doppler超声气泡探测仪检测到的级别愈高。血浆TxB_2、6-keto-PGF_(1α)值在濒死动物中明显升高(P<0.01);存活动物中,TxB_2经历了下降、再恢复的过程(P<0.01),而6-keto-PGF_(1α)值未见明显变化。消炎痛在抑制血浆TxB_2升高的同时,有效地降低了DCS发病率。此结果表明:TxA_2、PGI_2参与了重型DCS的发病过程,消炎痛的顶防作用与抑制花生四烯酸代谢物的生成有关。     

广东省传染性非典型肺炎流行病学特征初步调查

目的 了解广东省局部地区流行的传染性非典型肺炎(SARS)的流行病学特征，为制定预防控制对策和措施提供科学依据。方法 采用统一的流行病学个案调查表对病例进行调查。利用EPI6．0软件分析SARS病例在广东省的流行过程，地区、时间、人群分布及聚集性等特征。结果 SARS在广东省的发病率为1．72／10万，病死率为3．64％。发病主要集中在1月下旬至2月下旬(2月上旬达到高峰)，占病例总数的61．88％。地区分布以经济发达、人口流动频繁的珠江三角洲地区为主，占病例总数的96．66％；患者以青壮年居多；医务人员是高发人群，占病例总数的24．9％；有明显的家庭和医院聚集，聚集性病例占37．1％。结论 SARS是一种呼吸道传播为主的传染病，目前发现传染源是人，潜伏期1—12天，中位数4天；通过短距离飞沫和密切接触传播；人群普遍易感，病例主要集中在经济发达、人口流动频繁的珠江三角洲地区。