全文获取类型
收费全文 | 90154篇 |
免费 | 6403篇 |
国内免费 | 2583篇 |
专业分类
耳鼻咽喉 | 732篇 |
儿科学 | 1145篇 |
妇产科学 | 953篇 |
基础医学 | 12127篇 |
口腔科学 | 1912篇 |
临床医学 | 8053篇 |
内科学 | 12416篇 |
皮肤病学 | 1289篇 |
神经病学 | 6458篇 |
特种医学 | 2765篇 |
外国民族医学 | 7篇 |
外科学 | 9835篇 |
综合类 | 12273篇 |
现状与发展 | 9篇 |
一般理论 | 1篇 |
预防医学 | 6144篇 |
眼科学 | 1164篇 |
药学 | 12322篇 |
10篇 | |
中国医学 | 4386篇 |
肿瘤学 | 5139篇 |
出版年
2024年 | 179篇 |
2023年 | 1079篇 |
2022年 | 2802篇 |
2021年 | 3406篇 |
2020年 | 2534篇 |
2019年 | 5261篇 |
2018年 | 5004篇 |
2017年 | 3153篇 |
2016年 | 2267篇 |
2015年 | 2753篇 |
2014年 | 5344篇 |
2013年 | 5099篇 |
2012年 | 4359篇 |
2011年 | 4790篇 |
2010年 | 4294篇 |
2009年 | 4623篇 |
2008年 | 3793篇 |
2007年 | 4773篇 |
2006年 | 4193篇 |
2005年 | 3465篇 |
2004年 | 2407篇 |
2003年 | 2507篇 |
2002年 | 1949篇 |
2001年 | 1637篇 |
2000年 | 1435篇 |
1999年 | 1268篇 |
1998年 | 1401篇 |
1997年 | 1264篇 |
1996年 | 1110篇 |
1995年 | 959篇 |
1994年 | 856篇 |
1993年 | 710篇 |
1992年 | 691篇 |
1991年 | 653篇 |
1990年 | 516篇 |
1989年 | 490篇 |
1988年 | 430篇 |
1987年 | 417篇 |
1986年 | 363篇 |
1985年 | 744篇 |
1984年 | 748篇 |
1983年 | 495篇 |
1982年 | 573篇 |
1981年 | 481篇 |
1980年 | 448篇 |
1979年 | 343篇 |
1978年 | 251篇 |
1977年 | 229篇 |
1976年 | 198篇 |
1974年 | 124篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
11.
Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) in particulate matter that has a diameter of ≤2.5 μm (PM2.5). Studies have demonstrated that BaP exposure causes oocyte meiotic arrest in mice. However, whether BaP exposure also affects oocyte maturation in offspring remains unclear. To test this, female mice were administered BaP before pregnancy to generate BaP-exposed offspring. Our findings showed that BaP exposure reduced the in vitro maturation and increased the abnormalities of meiotic apparatus in offspring oocytes. In addition, BaP exposure reduced the mitochondrial content and intracellular ATP generation, induced early apoptosis, increased reactive oxidative species accumulation and the genomic DNA 5-methylcytosine (5mc) level in offspring oocytes. Along with the abovementioned defective parameters, maternal BaP exposure further compromised the embryo developmental competence of offspring oocytes. In summary, our study demonstrated that maternal BaP exposure compromised offspring oocyte maturation and quality. 相似文献
12.
M.F. Werner A. López-Rueda F.X. Zarco J. Blasco L. San Román S. Amaro E. Carrero R. Valero L. Oleaga J.M. Macho N. Bargalló 《Radiologia》2019,61(2):143-152
Purpose
Endovascular treatment with mechanical thrombectomy devices demonstrated high recanalization rates but functional outcome did not correlate with high rates of recanalization obtained. Patient selection prior to the endovascular treatment is very important in the final outcome of the patient. The primary aim of our study was to evaluate the prognostic value of posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) and Pons-Midbrain Index (PMI) scores in patients with Basilar Artery Occlusion (BAO) treated with successful angiographic recanalization after mechanical thrombectomy.Methods
Retrospective single-center study including 18 patients between 2008 and 2013 who had acute basilar artery occlusion managed with endovascular treatment within 24 hours from symptoms onset and with successful angiographic recanalization. The patients were initially classified into two groups according to clinical outcome and mortality at 90 days. For analysis we also divided patients into groups based on pc-ASPECTS (≥8vs.< 8) and PMI (≥3vs.< 3) on non-contrast CT (NCCT) and CT Angiography Source Images (CTASI). Imaging data were correlated to clinical outcome and mortality rate.Results
CTASI pc-ASPECTS, dichotomized at < 8 versus≥8, was associated with a favorable outcome (RR: 2.6; 95% CI: 1.3-5.2) and a reduced risk of death (RR: 6.5: 95% CI: 7.8-23.3). All patients that survived and were functionally independent had pc-ASPECTS score≥8. None of the 5 patients with CTASI pc-ASPECTS score less than 8 survived.Conclusion
PC-ASPECTS on CTASI is helpful for predicting functional outcome after BAO recanalization with endovascular treatment. These results should be validated in a randomized controlled trial in order to decide whether or not to treat a patient with BAO. 相似文献13.
14.
15.
《Clinical neurophysiology》2020,131(1):259-264
ObjectivesFasciculation potentials (FP) are an important consideration in the electrophysiological diagnosis of ALS. Muscle ultrasonography (MUS) has a higher sensitivity in detecting fasciculations than electromyography (EMG), while in some cases, it is unable to detect EMG-detected fasciculations. We aimed to investigate the differences of FP between the muscles with and without MUS-detected fasciculations (MUS-fas).MethodsThirty-one consecutive patients with sporadic ALS were prospectively recruited and in those, both needle EMG and MUS were performed. Analyses of the amplitude, duration, and number of phases of EMG-detected FPs were performed for seven muscles per patient, and results were compared between the muscles with and without MUS-fas in the total cohort.ResultsThe mean amplitude and phase number of FP were significantly lower in patients with EMG-detected FP alone (0.39 ± 0.25 mV and 3.21 ± 0.88, respectively) than in those with both FP and MUS-fas (1.22 ± 0.92 mV and 3.74 ± 1.39, respectively; p < 0.0001 and p = 0.017, Welch’s t-test).ConclusionSmall FP may be undetectable with MUS. MUS cannot replace EMG in the diagnostic approach for ALS.SignificanceClinicians should use a combination of EMG and MUS for the detection and quantitative analysis of fasciculation in ALS. 相似文献
16.
目的探讨改良内固定融合术治疗成人Ⅱ型痛性足副舟骨(painful accessory navicular,PAN)的疗效。方法2016 年 1 月—2017 年 12 月,采用改良内固定融合术治疗 29 例(37 足)Ⅱ型 PAN。其中男 12 例,女 17 例;年龄 18~50 岁,平均 41.4 岁。扭伤 24 例,无明显诱因 5 例。患者均行 6 个月以上保守治疗,症状无明显改善。术前及末次随访时采用美国矫形足踝协会(AOFAS)中足评分评估临床疗效;X 线片测量跟骨倾斜角、距骨第 1 跖骨角、距舟关节包容角、距骨第 2 跖骨角。结果术后 1 例出现切口浅表感染,经加强换药后愈合;其余患者切口均Ⅰ期愈合,无深部感染或骨髓炎发生。29 例均获随访,随访时间 12~33 个月,平均 25.1 个月。X 线片示关节面均于术后 2~5 个月愈合,平均 3.4 个月。随访期间未见内固定物松动或断裂。末次随访时,AOFAS 疼痛、功能、力线评分及总分以及距舟关节包容角、距骨第 1 跖骨角和距骨第 2 跖骨角均较术前显著改善,差异有统计学意义(P<0.05);跟骨倾斜角手术前后差异无统计学意义(t=1.097,P=0.276)。 结论采用改良内固定融合术治疗成人Ⅱ型 PAN 可有效缓解症状,患足功能恢复良好,并发症少。 相似文献
17.
18.
19.
20.
目的探讨单纯 Ilizarov 环形外固定技术治疗合并骨筋膜室综合征的胫骨平台骨折的疗效。方法2013 年 9 月—2017 年 3 月,收治 30 例合并骨筋膜室综合征的胫骨平台骨折患者,采用单纯 Ilizarov 环形外固定技术治疗。男 23 例,女 7 例;年龄 23~43 岁,平均 34.4 岁。致伤原因:交通事故伤 12 例,高处坠落伤 4 例,摔伤 8 例,重物砸伤 6 例。受伤至入院时间 1~12 h,平均 4.8 h。骨折 Schatzker 分型:Ⅱ型 1 例、Ⅲ型 3 例、Ⅳ型 10 例、Ⅴ型 7 例、Ⅵ型 9 例。30 例均因骨筋膜室综合征行切开减压;切开减压至手术时间为 10~15 d,平均 12.5 d。治疗后采用膝关节学会评分系统(KSS)及 Ilizarov 方法研究与应用协会(ASAMI)协议评价膝关节功能。结果手术时间 110~155 min,平均 123.1 min;术中出血量 100~500 mL,平均 245 mL;术后住院时间 3~5 d,平均 3.8 d。患者均获随访,随访时间 20~24 周,平均 22.7 周。除 2 例患者出现针道感染征象外,无其他并发症发生。X 线片复查显示骨折均愈合,愈合时间 10~20 周,平均 14.6 周。末次随访时,膝关节 KSS 临床评分总分为 70~95 分,平均 87.5 分;功能评分总分为 70~90 分,平均 79.0 分。参照 ASAMI 协议评价获优 24 例、良 3 例、可 2 例、差 1 例。结论对于合并骨筋膜室综合征的胫骨平台骨折,单纯 Ilizarov 环形外固定技术治疗后患者关节功能可以基本恢复且并发症少,是一项相对安全、有效的治疗方法。 相似文献