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61.
Takemi Noda 《Virchows Archiv : an international journal of pathology》1984,404(4):381-392
Summary Pathomorphological and angioarchitectural characteristics of esophageal varices, mainly of ruptured varices, were studied in autopsy cases. Contrast medium was injected into the esophageal vein in 25 among 75 cases with varices, and in 4 cases without varices as a control. Out of the 75 cases with varices, rupture was confirmed in 8 cases. Ruptured points were recognized at the oral end of the longitudinal veins (these veins were called sudare-like veins in this study) in the lamina propria at the lower end of the esophagus in all of the 8 cases. This ruptured area was called the critical area. By morphometric examination, dilatation of these sudare-like veins was the most obvious in severe varices, and these veins were observed to penetrate the muscularis mucosae to connect to the submucosal veins at the critical area. This area seemed to be of the greatest significance in the pathogenesis of spontaneous variceal rupture. 相似文献
62.
Tang D Yang C Zheng J Woodard PK Sicard GA Saffitz JE Yuan C 《Annals of biomedical engineering》2004,32(7):947-960
A three-dimensional (3D) MRI-based computational model with multicomponent plaque structure and fluid-structure interactions (FSI) is introduced to perform mechanical analysis for human atherosclerotic plaques and identify critical flow and stress/strain conditions which may be related to plaque rupture. Three-dimensional geometry of a human carotid plaque was reconstructed from 3D MR images and computational mesh was generated using Visualization Toolkit. Both the artery wall and the plaque components were assumed to be hyperelastic, isotropic, incompressible, and homogeneous. The flow was assumed to be laminar, Newtonian, viscous, and incompressible. The fully coupled fluid and structure models were solved by ADINA, a well-tested finite element package. Results from two-dimensional (2D) and 3D models, based on ex vivo MRI and histological images (HI), with different component sizes and plaque cap thickness, under different pressure and axial stretch conditions, were obtained and compared. Our results indicate that large lipid pools and thin plaque caps are associated with both extreme maximum (stretch) and minimum (compression when negative) stress/strain levels. Large cyclic stress/strain variations in the plaque under pulsating pressure were observed which may lead to artery fatigue and possible plaque rupture. Large-scale patient studies are needed to validate the computational findings for possible plaque vulnerability assessment and rupture predictions. 相似文献
63.
64.
目的探讨纤溶酶原激活剂抑制物-1(plasminogen activator inhibitor-1,PAI-1)基因4G/5G多态性和早期妊娠子宫动脉舒张期切迹与复发性自然流产的关系,为早期诊断和治疗复发性自然流产提供依据。方法应用聚合酶链反应-限制性片段多态性(PCR-RFLP)分析,对61例反复自然流产患者(病例组)和52例正常妊娠对照组(对照组)做了PAI-1基因4G/5G多态性分析,并应用彩色多普勒超声检测子宫动脉舒张期切迹(uterine artery diastolic notches depth,ND)结果1.复发性自然流产组有ND切迹者占54.1%(33/61),正常妊娠对照组为34.62%(18/52),二者差异有显著性意义(χ2=4.30,P<0.05,OR值为2.23,95%CI 1.04-4.77。2.携带4G/4G基因型患者其子宫动脉血流循环阻力有增加趋势,(χ2=16.08,P<0.01,OR值为6.0,95%CI 2.38-15.12。结论1.子宫动脉血流循环阻力增加与复发性自然流产的发病有关联。2.PAI-1基因4G/4G型个体,同时有ND者自然流产的风险为对照组的4.25倍... 相似文献
65.
Reuvit Halperin Arie Herman Abraham Golan Eran Hadas David Schneider Ian Bukovsky Raphael Ron-El 《American journal of reproductive immunology (New York, N.Y. : 1989)》1996,35(2):102-105
PROBLEM: To examine the relationship between the concentration of uterine fluid human decidua-associated protein (hDP) 200, identified as a monoclonal rheumatoid factor, and different phases of the menstrual cycle. METHODS: Sequential measurements of hDP 200 concentration in uterine fluid were performed in 11 normal ovulatory women, aged 22–36 years. The samples were collected in early proliferative phase, late proliferative phase, periovulatory period, early secretory phase, and late secretory phase. RESULTS: Consistent fluctuations of hDP 200 levels in uterine fluid were found throughout the menstrual cycle. High levels were found during early proliferative phase and periovulatory period related to significantly lower levels during late proliferative and early luteal phases. CONCLUSION: There is menstrual phase dependent variation in the uterine fluid levels of hDP 200. 相似文献
66.
Kawauchi S Okuda S Morioka H Iwasaki F Fukuma F Chochi Y Furuya T Oga A Sasaki K 《Human pathology》2005,36(10):1096-1100
Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a newly introduced category of the revised World Health Organization classification. We reported a case of cervical LCNEC with cytogenetic analysis by comparative genomic hybridization (CGH). The cervical tumor showed moderately increased mitotic activity (8-14 mitotic figures per 10 high-power fields) and focal necrosis, which made it problematic to differentiate from atypical carcinoid. CGH analysis failed to detect chromosome 11q loss that has been reported to be characteristic of pulmonary atypical carcinoids. Furthermore, chromosome 3q amplification, which has been detected frequently in pulmonary small cell carcinomas and LCNECs but not in pulmonary typical and atypical carcinoids, was the most remarkable chromosomal aberration. Although CGH reports are extremely rare in neuroendocrine tumors of the uterine cervix, specific chromosomal aberrations may be useful in their distinction. 相似文献
67.
M.R. Ahmadi A. Khodakaram Tafti S. Nazifi H.R. Ghaisari 《Comparative clinical pathology》2005,14(2):90-94
Reproductive tract abnormalities especially in the uterus and ovaries of cows often results in infertility. The object of this study was to determine the relationship between the cytology of uterine and cervical mucosa and endometrial histopathology in normal and endometritic cows. In this study, the genital tracts of 131 slaughtered cows were collected. According to macroscopic appearances and histopathological evaluation, reproductive tracts were divided into normal and abnormal. Cytological samples were obtained from the discharges of cervical mucosa and uterine fluid that were collected by wet cotton swab and gentle aspiration. Differential cellular counts were carried on Giemsa stained smears of the mucosa. Comparison of cell densities of normal cows with endometritic cows showed significant differences (P<0.05) in the macrophage presence both by swab (0.00±0.00) and aspiration (0.16±0.55) methods. Comparison of cell densities in different grades of endometritis showed a significant difference (P<0.05) in the neutrophil percentage in cervical mucosa between the swabbing and aspiration methods. In this study, there were no significant differences in cell densities between the two collection methods in cows affected with either acute or chronic endometritis. However, there was significant difference in the neutrophil density in aspirated cervical mucosa compared to the swab collection in cows affected with subacute endometritis. Cytological methods can be useful for the diagnosis of clinical and subclinical endometritis of cows. 相似文献
68.
Simona Gurzu Tivadar Bara Calin Molnar Tivadar Bara Vlad Butiurca Hanga Beres Simin Savoji Ioan Jung 《Pathology, research and practice》2019,215(1):82-89
Background
Pancreatic mucinous cystic neoplasms (MCN) are rare tumors that are usually diagnosed in females.Materials and methods
In our department, only four of the 109 consecutive cases of pancreatic tumors (3.67%) were diagnosed as MCNs. In this report, we present the characteristics of these four specific cases which also showed unusual HER-2 positivity and neuroendocrine differentiation.Results
The four MCNs were diagnosed in patients with ages between 46 and 75 years. Other clinical particularities were the following: one benign case, splenic rupture as result of a giant cystic tumor on the tail of the pancreas directly invading the spleen in the second one, metastases in the accessory spleen in the third one and invasion of the abdominal vessels in the fourth case. In all of these cases, the ovarian-like stroma tested positivity for calretinin, progesterone receptor (PR) and, in cases 2 and 3, for AE1/AE3 keratin. The malignant tumor cells were marked by carcinoembryonic antigen, HER-2, maspin, PR and the neuroendocrine markers synaptophysin, CD56, and neuron-specific enolase.Conclusions
These cases highlight the unusually aggressive behavior of pancreatic MCN with invasive carcinomas that share mixed exo- and endocrine components and show epithelial-mesenchymal transition. 相似文献69.
目的:探讨经阴道彩色多普勒超声对子宫腺肌瘤的诊断价值。方法:选取许昌中医院2020年1月至2022年1月期间收治的80例子宫腺肌瘤患者为研究对象,对上述患者实施经阴道彩色多普勒超声诊断,获得对应的诊断结果,随后将该结果和术后病理分析结果进行比较,最终得出诊断效果。结果:本研究80例子宫腺肌瘤患者中,经阴道彩色多普勒超声检出75例,漏诊或误诊5例,诊断准确率为93.75%;经阴道彩色多普勒检查诊断为子宫腺肌瘤的75例患者中,按照发病部位划分,有10例(13.33%)子宫腺肌瘤出现在子宫前壁区域,65例(86.67%)出现在子宫后壁部位;按照病情特点划分,有63例(84.00%)为单发子宫腺肌瘤,12例(16.00%)为子宫腺肌瘤合并子宫肌瘤。此外,75例患者中有3例患者并发卵巢内膜异位症。75例患者的子宫动脉血流阻力指数为0.75±0.05、搏动指数为1.37±0.04、舒张期峰值速度为(5.83±0.14)cm·s-1、收缩期峰值速度为(71.74±0.25)cm·s-1。结论:经阴道彩色多普勒超声可通过超声特征、血流分布、多普勒频谱特点,准... 相似文献
70.
目的对比宫腔镜下宫腔粘连电切术后宫腔放置子宫球囊支架或宫内节育器预防宫腔粘连的效果。方法选取行宫腔镜下宫腔粘连电切术的60例患者,随机分为两组各30例。观察组术后置入COOK球囊型子宫支架,对照组术后置入宫内节育器。比较两组的术后出血情况以及临床疗效。结果观察组术后48 h的中度、重度出血发生率显著低于对照组,出血量显著少于对照组(P <0.05)。观察组的总有效率为96.67%,显著高于对照组的80.00%(P <0.05)。结论宫腔镜下宫腔粘连电切术后宫腔放置子宫球囊支架能够减轻术后出血症状,有效预防粘连复发,效果优于置入宫内节育器。 相似文献