基于改良动手深度学习算法的冠心病病变全程证候要素分布与组合规律研究＊

目的 探索冠心病病变全程的证候要素分布与组合规律。方法 基于冠心病证候、证候要素诊断的行业标准，运用改良动手深度学习（Transformer）算法构建冠心病证候要素诊断系统，对比系统诊断结果与4位临床医师基于治疗指南的诊断结果，获知系统证候要素诊断准确性；借助冠心病证候要素诊断系统对中国中医科学院广安门医院的1221例冠心病住院病例进行证候要素诊断及不同分期证候要素分布、组合规律研究。结果 通过临界病变、冠心病心绞痛未行介入手术、冠心病心绞痛介入术后12周内、冠心病心绞痛介入术后1年以上并伴心功能降低（NYHA分级为II级或III级）患者病例各20例的人、机对比，冠心病证候要素诊断系统平均准确度可达96.46 ± 8.957%。冠心病证候要素诊断系统对证候要素判断结果提示，冠心病冠脉临界病变阶段以气滞、血瘀的实性证候要素及组合为主；冠心病心绞痛未行介入手术阶段存在血瘀、气虚、痰浊、气滞等实性证候要素为主的分布及其组合形式；冠心病介入术后12周内的患者可呈现阴虚、气虚、气滞、血瘀等证候要素分布及其组合形式；冠心病介入术后1年以上伴心功能不全的患者多表现为气虚、痰浊、阳虚等虚性证候要素为主的证候要素分布及组合形式。结论 冠心病病变全程的证候要素分布及组合形式存在一定时间性的演变规律，可出现由实性证候要素向虚实夹杂的证候要素分布及组合形式演变，最终发展成虚性为主的证候要素分布及组合模式，而基于深度学习算法的冠心病证候要素辨证系统为证候要素诊断的客观化提供途径。     

Homicide by hanging: A case report and its forensic-medical aspects

We report a rare case of homicide by hanging. The postmortem examination resulted in a verdict of death by suicidal hanging and the Public Prosecutor's Office released the body for burial. After intervention by the relatives police investigations were resumed. Based on evidence impossible to reconcile with the results of the postmortem examination and requiring further clarification, an autopsy was ordered. The results of the postmortem could not be brought in line with a suicidal hanging and were further substantiated by DNA analysis. The scenario put forward by the defense claiming a secondary transfer of trace evidence onto the ligature and the victim's clothes was excluded because of the distribution pattern and the trace evidence ratio. The defendant was sentenced to 20 years of prison for homicide. The verdict was confirmed by the Supreme Court and commuted to 18 years.     

Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula

ObjectiveTo reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis (AD).MethodsSixty specific-pathogen free male BALB/c mice were randomly divided into the control group, model group, whole formula group (WF), exterior-releasing formula group (ERF), interior-clearing formula group (ICF), and positive control group (PC). A mouse model of AD was established using the semi-antigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and pH, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin, and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.ResultsMice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.ConclusionsMahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD.     

54名赫哲族学龄儿童头发中元素的检测及分析

本文对107名学龄儿童(赫哲族54名,汉族53名)头发中锌、铜、铁、钙、镁及钾进行测定。其结果发现:除发钾外,其它元素在性别上存在显著差异;发锌和发铜与国内文献报道存在地区差异;六种元素含量在种族间未见显著差异。     

Effect of trace elements on the kinetics of calcium oxalate crystallization—Research on urolithiatic inhibitors

Summary In order to find effective urolithiasis inhibiting factors, calcium oxalate stones were investigated by spectrum analysis. Of the composite trace elements nine were selected to test their effect on the kinetics of calcium oxalate crystallization in artificial and in urinary stone patient’s urine, and in experimental animals respectively. It was found that Mo and Sr could effectively inhibit calcium oxalate crystallization and decrease the renal total and crystalline calcium. The inhibitive effect of the trace elements, the mechanism of action, the required conditions and the way of their affecting the kinetics of calcium oxalate crystallization are discussed. Their clinical significance and the possibility of practical application are referred to.     

下颌双侧游离端可摘局部义齿咀嚼运动实验研究

本研究用下颌运动轨迹描记实验、咀嚼功能测定及应变电阻仪测试实验,对戴用3种不同设计的固位体的下颌双侧游离端可摘局部义齿患者在咀嚼食物时,观察并分析咀嚼运动,以比较3种义齿下颌运动型、基托及舌杆的应力分布及咀嚼功能,进一步分析何种设计最佳。同时提出对基托及舌杆设计中的较佳方案。     

Influence of polyhemoglobin composition on erythrocyte aggregation and circulation time

Translated fromByulleten' Pksperimental'noi Biologii i Meditsiny, Vol. 115, No. 1, pp. 27–29, January, 1993     

山东栽培丹参的质量考察

通过薄层、纸层—紫外和薄层—扫描等方法,对同一地区的栽培和野生丹参进行了化学成分、微量元素及抑菌作用等方面的比较,结果表明:栽培丹参能够同野生品一样供药用。