Oral glucose tolerance test does not affect degree of hemoglobin glycation as measured by routine assay

BackgroundHemoglobin A1c (HbA1c) is an accurate index of fluctuation in glycemia over the 2-3 months prior to quantitative assessment. During this time, hemoglobin (Hb) slowly glycates until it shows the properties of advanced glycation end-products. Glycation kinetics is intensified by prolonged glucose exposure. In subjects undergoing oral glucose tolerance testing (OGTT), immediately after ingestion, glucose is ostensibly transported by the glucose transporter 1 (GLUT1) to erythrocyte corpuscular hemoglobin. The earliest significant measurable level of hemoglobin glycation associated with this transportation is still not clear.Subjects and methodsWe attempted to explore the early impact of short-term glucose load on HbA1c levels, because it is now known that transmembrane GLUT1-mediated glucose transport occurs immediately. A total of 88 participants (46 patients and 42 clinically healthy controls) underwent fasting plasma glucose quantitation during an OGTT. HbA1c, revealed by a monoclonal anti-glycation epitope antibody and adiponectin, was quantitated before (T0) and 2 hours (T120) after 80 g glucose ingestion.ResultsWilcoxon test revealed that the HbA1c values did not significantly vary (P = 0.15) during the OGTT, whereas glucose concentration varied strongly between T0 and T120.DiscussionIt is well known that quantitative estimation of HbA1c is informative for clinical care, independently of glucose level. The molecular mechanisms and dynamics by which glucose enters/exits red blood cells are incompletely known and may differ between individuals. We here show, for the first time, that HbA1c levels do not significantly increase during OGTT, supporting the view that non-enzymatic glycation of hemoglobin occurs slowly and that glycation during the 2 hours of an OGTT is insignificant.     

The use of the Rey 15-Item Test and recognition trial to evaluate noncredible effort after pediatric mild traumatic brain injury

The Rey 15-Item Test (FIT) is a performance validity test commonly used in adult neuropsychological assessment. FIT classification statistics across studies have been variable, so a recognition trial was created to enhance the measure (Boone, K. B., Salazar, X., Lu, P., Warner-Chacon, K., & Razani, J. (2002). The Rey 15-Item recognition trial: A technique to enhance sensitivity of the Rey 15-Item Memorization Test. Journal of Clinical and Experimental Neuropsychology, 24(5), 561–573.). The current study assessed the utility of the FIT and recognition trial in a pediatric mild traumatic brain injury sample (N = 319, M = 14.57 years). All participants were administered the FIT and recognition trial as part of an abbreviated clinical neuropsychological evaluation. Failure on the Medical Symptom Validity Test was used as the criterion for noncredible effort. Fifteen percent of the sample met the criterion. The traditional adult cutoff score of <9 on the FIT recall trial yielded excellent specificity (98%), but very poor sensitivity (12%). When the recognition trial was utilized, a total score of <26 resulted in the best combined cutoff score (sensitivity = 55%, specificity = 91%). Results indicate that the FIT with recognition trial may be useful in the assessment of noncredible effort with children and adolescents, at least among relatively high-functioning populations.     

痔体黏膜发现白色念珠菌寄生

为探讨痔的病因,将26例患者痔体送病理组织检查,PAS染色发现9例有紫红色菌体寄生,据其形态判断是白色念珠菌,试管沙氏培养基培养见奶白色酵母样菌落,转种于科玛嘉培养基培养见菌落呈翠绿色,诊断为白色念珠菌。由此推断痔上皮增生、角化,黏膜大量炎细胞浸润,间质水肿、出血,黏膜下静脉强烈炎性变,是因白色念珠菌感染引起的。     

初中生“基本认知能力测验”信效度分析

目的初中生"基本认知能力测验"信效度分析。方法以中国社会科学院心理研究所基本认知能力测验系统(2.0版)为工具,对分层随机抽取的300名初中生进行认知能力测试。结果①各分量表重测信度比较高,其相关系数分别是:数字拷贝0.90,汉字比较0.73,心算0.75,汉字旋转0.62,数字工作0.91,双字词再认0.59,无意义图形再认0.56,均达到显著水平(P0.05);②因素分析发现基本认知能力测验有6个纬度,分别是:数字拷贝、双字词再认、数字加工、数字工作、汉字比较、心算。结论基本认知能力测验信效度较好,能很好的反映初中生的认知状况。     

The Use of the EmotionalStroop Test to Establish the Onset and Efficacy of Antipsychotic Activity

Twenty-eight subjects who met criteria for delusional disorder, of whom 16 were on neuroleptic treatment and 12 were not, were tested using an Emotional Stroop Test to measure aspects of their deployment of attentional resources in response to emotionally valent material. Interference indices were calculated to assess their level of accommodation to depressive, anxiety-related and threat-related words. Those who were on neuroleptics demonstrated significantly less interference from anxiety and threat-related words, raising the possibility that this test might provide a sensitive measure of the onset and efficacy of antipsychotic activity. The differential effects on anxiety and threat-related words also suggest that the antipsychotic activity of current neuroleptics is non-specifically tranquillizing rather than specifically psychotolytic in nature.