婚姻状态对结直肠神经内分泌肿瘤患者远期预后的影响

目的探讨婚姻状态与结直肠神经内分泌肿瘤患者远期预后的关系。方法 利用美国SEER数据库中1988至2011年间诊断为结直肠神经内分泌肿瘤(不包括阑尾)的病例回顾性分析婚姻状态与总因死亡(overall-cause mortality, OM)和肿瘤特异性死亡(cancer-specific mortality, CSM)的关系;应用单因素和多因素Cox分析婚姻状态(已婚,未婚和离异、分居、丧偶)对结直肠内分泌肿瘤远期预后的影响。结果 共入组2962例患者中,已婚组占60%,未婚组占14%,分居、离婚、丧偶(SDW)组占26%。多因素Cox回归分析表明,相比于已婚组及未婚组,SDW组的肿瘤特异性死亡(HR=1.15, P=0.038)和总因死亡(HR=1.19, P=0.002)均较高;相比于已婚组,未婚组总因死亡(HR=1.24, P=0.006)较高。结论 SDW患者有较高的CSM和OM;该风险独立于年龄、ENETS分期、肿瘤位置、就诊年份。提醒医务人员在这类患者诊治过程中应提供更多关注。     

首届订单定向医学毕业生就业现状研究

目的:描述分析首届订单定向医学毕业生的就业现状,评价订单定向医学生培养项目实施效果,发现存在的问题并提供相关的政策建议。方法:对中西部4所医学院校的2015届305名订单定向医学毕业生和315名临床五年制医学毕业生进行随访调查。分析其履行合约、参加工作及住院医师规范化培训情况。结果:订单定向毕业生合约履行率99.3%。订单定向毕业生和临床五年制毕业生到乡镇卫生院工作的比例分别为90.7%、2.8%,月平均收入分别为2 011元、2 774元,参加住院医师规范化培训的比例分别是77.8%、43.3%。结论:4所医学院校首届订单定向医学毕业生履行合约及参加住院医师规范化培训情况良好,但工作编制和待遇落实较为滞后,订单定向和住院医师规范化培训之间的关系尚未明确。建议在订单定向医学生毕业前,医学院校尽早与地方卫生行政部门和人力资源与社会保障部门协调联系,及早落实医学生的就业工作。同时,在充分协商的基础上,尽快明确订单定向医学生参加住院医师规范化培训的程序和要求。     

Perceived Value of a Pharmacy Resident Teaching Certificate Program

Objective

To determine the value of completing a pharmacy resident teaching certificate program on graduates'' current positions of employment.

Design

Annually from 2003 to 2007, program graduates of the Indiana Pharmacy Teaching Certificate (IPTeC) program were invited to take a 13-question Web-based survey 1 year after completing the program.

Assessment

Fifty-three of the 62 graduates (85%) surveyed responded. Almost half of the respondents strongly agreed or agreed that having completed the IPTeC program helped them obtain their current position. More than 90% of respondents agreed or strongly agreed that the seminar participation and teaching experience from the IPTeC program helped them in their current position. About 80% of respondents would recommend the program to others.

Conclusion

Completing a pharmacy resident teaching certificate program helped some graduates obtain and excel in their current position.     

基于疫苗全程电子追溯体系的河南省国家免疫规划疫苗损耗分析

目的：通过疫苗电子追溯体系精准测算河南省国家免疫规划疫苗的损耗情况,为进一步实现精细化疫苗管理、合理降低疫苗损耗提供科学依据。方法：利用河南省免疫规划信息管理系统省级平台及疫苗电子追溯系统收集2021年河南省预防接种门诊疫苗接种数据和使用数据。利用国家全民健康保障系统收集河南省预防接种门诊服务周期、服务半径等数据。结果：2021年河南省单剂次包装疫苗的损耗系数在1.01～1.06之间,最大为乙肝疫苗;多人份疫苗损耗系数在1.45～1.92之间,最大为卡介苗。2021年河南省不同市（县） 11种国家免疫规划疫苗的损耗系数存在一定差别。多数国家免疫规划疫苗的损耗系数在不同服务周期、不同服务半径、不同服务人口、不同门诊工作人员数量的接种门诊间存在一定差别。结论：除乙肝疫苗外,河南省其他国家免疫规划疫苗损耗系数均小于国家标准,说明河南省疫苗损耗管理相对较好,达到了国家工作要求。多人份疫苗和个别单人份疫苗损耗较大,应合理安排门诊周期,将接种日当天的接种人口密度控制在合理范围内,以提高疫苗利用效率。     

妊娠期梅毒患者胎儿宫内感染的超声诊断研究

目的:探讨超声对诊断梅毒感染孕妇宫内感染的意义。方法:选取2012年4月至2014年3月来院就诊并确诊为妊娠合并梅毒的孕产妇46例,本研究根据所选妊娠合并梅毒孕妇是否发生宫内感染,分为发生宫内感染组(观察组)和未发生宫内感染组(对照组),对比两组患者的产前宫内超声诊断结果,分析可以用于判断早期胎儿宫内感染的指标。结果:将观察组和对照组患者的产前早中期超声检测结果进行统计学分析发现,两组检测指标在胎囊不规则(0 vs.23.1%),胎心异常(5.0%vs.19.2%)、胎动异常(10.0%vs.15.4%)和胎盘水肿(0 vs.23.1%)等方面均具有差异性(χ2=9.000,4.410,3.889,1.440,9.000,P<0.01),具有统计学意义。孕后期超声检查结果显示两组之间在宫内窘迫(15.0%vs.69.2%)、全身水肿(0 vs.46.2%)、腹水(0 vs.61.5)、肝肿大(0 vs.88.5%)和脾肿大(0 vs.88.5%)等方面差异显著,具有统计学意义(χ2=10.10,12.49,61.54,88.46,88.46,P<0.01)。结论:产前超声监测可以为临床医生提供全面且直观的临床数据,有利于诊断和评估患者的病情,减少新生梅毒儿的数量。     

The Spanish “Century XXI” academy for developing elite level basketballers: design,monitoring and training methodologies

Objectives: The XXI Century Academy was a 6-year state-initiated intervention program that served as an alternative to basketball clubs for players in the u-14 and u-18 age groups in Spain, under guidelines established by the Spanish Basketball Federation. It was an important and unique project on talent development in basketball. To the best of the authors’ knowledge, no evidence has been reported on long-term athlete development programs in basketball worldwide. The main aim of this report is to describe the design and evaluation methods used for the XXI Century Academy as a long-term intervention program in the elite Spanish Basketball Academy, aiming to prepare basketball players to compete at the elite level.

Methods: The monitoring time lasted from 1996 to 2001. A total of 55 players were assigned to the intervention groups based on age, position, maturation level, and country of origin. During this process, participants competed in up to two categories in addition to playing competitive official matches worldwide in international tournaments in their categories and with the national team in the European and World Championships (u-14 - u-18). Participants included 1 NBA player, 3 national A Team players, 10 ACB (First Spanish League) players, 5 LEB (second League) players and 39 LEB-2 EBA (third League) players. Assessments took place in a High-Performance Sports Center (CPT FADURA-GETXO- Basque Government, Getxo, Vizcaya, Spain) and consisted of health questionnaires, anthropometric measures, blood parameters, maturation level, birth age, fitness tests, training volume and intensity, physical activity, technical and tactical training, dietary intake, supplementation and injuries. Each player was assessed 4 times per year (September, December, April, June) for 4 years (16 data points).

Results: This is a purely methodological paper describing the design and evaluation methods used in the XXI Century Project, which will be used as a basis for future reporting of results. Therefore, the results of the project will be reported in subsequent publications.

Conclusion: The viability of the Century XXI Project protocols has been described. This national project of training in basketball closely replicates the physical and technical match-play conditions for professionals and may constitute a useful training tool.     

基于多核处理器的PLC控制程序并行执行

针对可编程逻辑控制器（Programmable Logic Controller,PLC）的编程语言不支持程序的并行编译,无法使控制程序并行执行于多核处理器的问题,根据功能块图的可拆分性,提出了用有向无环图（Directed Acyclic Graph,DAG）任务模型表示PLC控制程序的方法,并采用静态列表任务调度算法,优化DAG中的任务节点在不同CPU核上的分配调度,解决了PLC控制程序并行执行时会遇到的通信延时问题。此外,针对变量资源的竞争问题提出了使用互斥量的方法。实验结果表明,此方法能有效地将PLC控制程序并行运行在多核处理器上,大大缩短了程序的执行时间。