一站式便民服务中心在县级公立综合性医院的应用实践与研究

目的：探讨县级公立综合性医院构建一站式便民服务中心的效果。方法：在县级公立综合性医院构建一站式便民服务中心,对其效果采用调查问卷法分析,就突出问题开展访谈,并采用描述性统计及定量、定性分析。结果：该中心能够显著降低患者就诊询问次数和就诊路程,但总就诊时间无明显缩短。结论：在县级公立综合性医院构建一站式便民服务中心可以有效提高门诊办公效率,方便病员就诊,提高病员的满意度,在操作上是可行的,也是有效的。     

Investigations of excess environmental risks around putative sources: statistical problems and a proposed test

Individual reactions to a report which identifies an excess of risk near a putative source are determined mainly by some quoted significance level. One reaction, involving a commonly used 'coincidence' argument is given a simple Bayesian explanation. It is argued that interpretations of such reports should if possible allow both for data selection and for uncertainty in the null expectations underlying the significance levels. Tests are proposed, based on the first isotonic regression estimator under an order restriction, which allow for the effects of selecting a study region in the light of the data and have a simple form. Data on cancer incidence around two nuclear plants are used to illustrate.     

辛伐他汀治疗无症状性颈动脉粥样硬化的疗效观察

目的采用颈动脉超声观察辛伐他汀治疗无症状性颈动脉粥样硬化的疗效。方法对参加我院健康体检时经彩超检查发现有颈动脉斑块的观察病例68例，每晚服用辛伐他汀，连续4月，观察颈动脉斑块的面积变化以及血脂的动态改变。结果68例观察者共发现斑块112个，服药4月后发现低回声斑块面积消退幅度达32％，混合性斑块达25％，高回声斑块只有9％，平均消退幅度22％，除高回声斑块外，其他均有明显统计学意义（P〈0．05）。患者的TC下降与治疗前比较有显著差异（P〈0．01），TG、LDL的下降与治疗前比较有明显差异（P〈0．05），HDL有所升高，但无统计学意义。结论通过观察服用辛伐他汀4月后斑块的面积变化以及血脂的改变结果表明，坚持服用他汀类药物，可以达到稳定与消退斑块的作用。     

缓解期精神分裂症患者抑郁和自尊状况的调查及心理干预

目的了解缓解期精神分裂症患者抑郁/自尊状况及心理干预对其的影响。方法采用抑郁自评量表(self-ratting depression scale,SDS)及自尊量表(self-esteem scale,SES)对56例缓解期精神分裂症患者进行问卷调查,随机抽取其中20名患者进行深入访谈并进行逐步分析。根据调查分析存在的心理问题,有针对的实施为期6周的心理干预,然后再次测评SDS及SES,并与干预前进行比较。结果进行心理干预前后,缓解期精神分裂症患者SDS评分由(48.96±5.95)下降至(41.76±6.72);SES评分由(26.72±7.84)上升至(34.51±8.63);其差异有统计学意义(P<0.01)。结论缓解期精神分裂症患者存在多种内心体验而表现出抑郁或自卑,心理干预可改善缓解期精神分裂症患者的抑郁和自卑。     

描述性分类法用于门诊护理管理的效果观察

目的 探究描述性分类法应用于门诊护理管理的效果以及应用价值。方法 以简单随机抽样法纳入32名门诊护理人员作为研究对象,2018年1—12月未实施描述性分类法管理,设置为参照组,2019年1月—2020年1月后实施描述性分类法管理,设置为管理组,以统计学对两组管理期间护理活动量表评分（nursing activities score,NAS）、护理水平、不良事件发生情况以及管理满意度等数据进行处理分析。结果 管理组卫生保健、活动和体位、管理和输液、患者和家属支持与护理、行政和业务管理工作等护理活动方面的评分明显高于参照组,差异有统计学意义（P <0.05）。管理组护理技术评分、护理态度评分、护理质量评分均明显高于参照组,差异有统计学意义（P <0.05）。管理组发生意外伤害、护理差错、护患纠纷以及投诉等不良事件发生率6.25%明显低于参照组25.00%,差异有统计学意义（P <0.05）。管理组门诊护理人员满意度明显高于参照组,差异有统计学意义（P <0.05）。结论 描述性分类法应用于门诊护理管理中可提高管理期间护理活动以及护理水平,减少各种不良事件的发生,护理...     

The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery

Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-fold expression in the intestinal epithelial cells of diabetic rats, mediates the uptake of the folic acid-grafted nanoparticles (FNP). Specifically, the upregulated PCFT could exert its function to mediate the endocytosis of FNP and efficiently stimulate the traverse of FNP across enterocytes by the lysosome-evading pathway, Golgi-targeting pathway and basolateral exocytosis, featuring a high oral insulin bioavailability of 14.4% in the diabetic rats. Conversely, in cells with relatively low PCFT expression, the positive surface charge contributes to the cellular uptake of FNP, and FNP are mainly degraded in the lysosomes. Overall, we emphasize that the upregulated intestinal transporters could direct the uptake of ligand-modified nanoparticles by mediating the endocytosis and intracellular trafficking of ligand-modified nanoparticles via the transporter-mediated pathway. This study may also theoretically provide insightful guidelines for the rational design of transporter-targeted nanoparticles to achieve efficient drug delivery in diverse diseases.     

吉林农村寄宿中学生生长发育水平调查分析

目的了解吉林省农村寄宿中学生生长发育状况。方法采取整群随机抽样方法,从吉林省某农村寄宿中学生中抽取13～18岁学生127名,对其生长发育指标（年龄、性别、身高、体重、三头肌部皮褶厚度、上臂围、上臂肌围、胸围、腰围、臀围）进行调查,并计算体重指数、腰臀比。结果在身高、体重、上臂围、胸围、腰围、臀围方面,男女生之间有显著差异（P〈0.05）。被调查对象青春期生长有突增的现象。结论吉林省农村寄宿中学生的生长发育指标随年龄增加呈增长的趋势,符合一般生长发育的规律。     

眼罩模拟联合过渡期护理干预在重睑手术患者中的应用效果

目的 观察对重睑手术患者应用眼罩模拟联合过渡期护理干预的效果。方法 选取2021年2月-2023年 2月于我院行重睑手术的76例患者为研究对象,随机分为对照组和观察组,每组38例。对照组给予常规护 理,观察组给予眼罩模拟联合过渡期护理干预,比较两组满意度、舒适度、生活质量、血压及心率水平。 结果 观察组满意度各项评分均高于对照组（P ＜0.05）;观察组干预后社会环境、生理、文化、心理评分 均高于对照组（P ＜0.05）;观察组生活质量各维度评分均高于对照组（P ＜0.05）;观察组术前、术中、 术后收缩压、舒张压均优于对照组（P＜0.05）;观察组术前、术中、术后心率均优于对照组（P＜0.05）。 结论 眼罩模拟联合过渡期护理干预在重睑手术患者中的应用效果确切,可提高患者的舒适度,改善其生 活质量,有利于提升护理满意度,减少患者血压及心率波动,值得临床应用。     

Mussel oligopeptides ameliorate cognition deficit and attenuate brain senescence in d-galactose-induced aging mice

Dietary supplementation exerts beneficial effects in reducing incidence of chronic neurodegenerative diseases. The purpose of this study was to examine protective effects of mussel (Mytilus edulis) oligopeptides supplementation on brain function in d-galactose induced aging mice. Sixty female 8-month-old mice were randomly divided into five groups: vehicle control, d-galactose, and d-galactose combined with 200, 500, 1000 mg/kg mussel oligopeptides. The results showed that mussel oligopeptides could improve cognitive learning and memory ability and protect the hippocampal neurons. In addition, GSH, SOD and GSH-pX activities were increased and MDA level was significantly decreased in mice fed with mussel oligopeptides. It was also found that mussel oligopeptides supplementation prevented d-galactose-induced elevations of iNOS activity and NO production and lactate acid levels in brain. Moreover, PI3K and Akt genes were up-regulated by mussel oligopeptides supplementation. These findings suggest that mussel oligopeptides are able to enhance exercise capacity and protect against oxidative damage caused by d-galactose in aging model mice through regulating oxidation metabolism and PI3K/Akt/NOS signal pathway. Therefore, mussel oligopeptides are good materials for future development of healthcare products to combat age-related brain dysfunction and to improve healthy life span.