氚标记黄腐酸在小鼠体内的吸收、分布、排泄的研究

黄腐酸是一种水溶性较好,分子量较小的腐植酸。它具有抗肿瘤及免疫兴奋作用,给小鼠经口灌胃~3H-黄腐酸后15分钟,血中即可测到放射性,4小时达高峰,72小时后血中仍可测到少量放射性。腹腔注射~3H-黄腐酸后,肾、肝、血及骨组织中放射性最高,脾、肠、胃、肺、肌、胸腺及脑组织中依次减少;经口灌胃后,放射性在胃、肾、血、肝组织中最高,肠、心、脾、肺、胃、肌、胸腺及脑组织中依次减少。腹腔注射后,24小时内自尿及粪分别外排34.2%及24.2%,口服后分别从尿及粪排泄13%及62%。     

The estimation of moments: A technical note

The calculation of several common pharmacokinetic parameters requires estimates of both the area under the curve of the concentration of the drug in a sampled fluid vs. time, and also the first moment about t=0 of this area. It is proposed that the methods used to estimate these quantities should make consistent assumptions about the concentration of the drug. There appears to be an inconsistency in the standard published formulas in the case where concentration is interpolated linearly. A more consistent formula is derived.     

口服核素胆囊显相剂~(131)Ⅰ—甲苯胺蓝在小鼠体内的动态观察

~(131)I—甲苯胺蓝是一种口服胆囊显相剂。本实验采用LKB—2250PWV大型整体半自动冷冻切片机进行连续切片,用整体放射自显影术研究该药在小鼠体内的分布情况。本品口服后能很快吸收,进入到胆囊,并维持较长时间,而在胃肠及肝内分布较少。实验提示了该药可能通过肝肠循环进行代谢在胆囊聚集并通过胃肠道及肾脏排泄。     

片剂溶出度测定数据处理的电子计算机程序——解析法求算威布尔分布参数

本文对片剂溶出度的测定数据设计了以解析法求算威布尔分布参数的方法,并给出了电子计算机程序。     

Simulation of the deformation of materials in shoe uppers in gait. Force distribution using finite elements

This paper presents a computational model that simulates the deformation of materials in shoe uppers and that quantifies the distribution of forces on the foot surface in a complete step. A preliminary linear elastic model based on the finite element method was developed for the upper, using a simple triangular element of three nodes. This model can be used for different feet of the same size, for sizes of the same design, and for materials with different elastic parameters. The aim of this model is to provide functional and aesthetic valuation in CAD (computer assisted design) footwear design. The application achieved will be the first tool to provide footwear manufacturers with the capacity to value the functional features of a design virtually, without having to make prototypes or use footwearers. This application will minimize the time and the costs that a new shoe collection generates.     

MAA存在下VAc/BA核壳乳液聚合过程中的胶粒形态研究

用ＴＥＭ和电位滴定法对不同配方和工艺条件得到的胶粒形态结构和羧基分别进行了表征。结果表明：加入甲基丙烯酸有利于胶粒的稳定和形成规则的核壳胶粒。半连续加料不会形成完全反转的核壳结构，但是，核层在反应过程中由于聚合物簇的迁移会造成形变。由于胶粒中聚合物浓度高，粘度大，因而胶粒形态变化受动力学影响甚大，羧基分布主要是由动力学确定的。     

A case of sudden death after gingival injection of a therapeutic dose of lidocaine: distribution of lidocaine in whole blood and various tissues

We report a case of sudden death after gingival injection of lidocaine, which made us suspect overdosing or anaphylactic shock. Using liquid chromatography-mass spectrometry (LC-MS), we measured the lidocaine concentrations in whole blood and tissues including the gingivae. The lidocaine concentration in blood (0.70 μg/ml) was lower than the therapeutic level. Lidocaine levels distributed to various organs were also low. Among them, the lung showed the highest level, followed by the liver, brain, and spleen. The concentrations in the gingivae with and without pus were 938 μg/g and 1048 μg/g, respectively. Together with the above analytical data, we made histopathological examinations, and tryptase and immunoglobulin E (IgE) assays as markers of anaphylactic shock. Macroscopically, myocardial ischemic changes were observed over relatively large areas. In such cardiac areas, there were focal necrosis, disarrangement of cardiac muscles, and stromal edema microscopically. The tryptase value was within the normal range. By carefully considering all data obtained from the victim, we diagnosed that the victim died of heart failure under the stress of the dental treatment.     

阿霉素毫微粒肝动脉灌注后在荷肝肿瘤鼠体内的分布研究

目的 检测阿霉素毫微粒（ＮＡＤＭ）与游离阿霉素（ＦＡＤＭ）经肝动脉灌注后荷肝肿瘤鼠体内的药物分布，并比较其差异。方法 ＳＤ纯系大鼠３０只，建立Ｗ２５６移植性肝癌模型并随机分为两组，每组各１５只动物，经肝动脉以２ｍｇ／ｋｇ药物剂量分别注入ＮＡＤＭ与ＦＡＤＭ，每组于给药后１小时，５小时，１５小时各处死５只大鼠，分别提取血浆，肝，心，脾，肺，肾，肝肿瘤样品，采用反相高效液相色谱荧光检测法（ＲＰ－ＨＰＬＣ     

新疆蝇类研究：Ⅳ.粪蝇科,寄蝇科,胃蝇科,狂蝇科,皮蝇科,虱蝇科,食 …

新疆蝇类研究第Ⅳ报报告了对粪，寄，胃，狂，皮，虱，食蚜蝇７科的研究结果，共２８属４４种，中国新记录种２个。