Seasonal variation in the occurrence of ischemic stroke and subarachnoid hemorrhage in Siberia, Russia. A population-based study

Epidemiological studies on the relationship between stroke occurrence and the seasons in different countries produced inconsistent results and little is known about these associations in a general population. We report a population-based study of 214 patients with first-ever ischemic stroke (IS, data for 1992) and 64 patients with first-ever subarachnoid hemorrhage (SAH) registered in the 25–74 years old population of Oktiabrsky District of Novosibirsk, Russia in 1982–92. IS and SAH incidence in four seasons (winter, spring, summer, autumn) was evaluated by means of a chi-square test. Poisson regression analysis was used to compute the rate ratios (RRs) and corresponding confidence intervals (CIs) for the occurrence ofIS and SAH in winter, spring, and autumn compared with summer. Seasonal variations in the occurrence of IS were significant for the group of young men (25–64 years) and the group of older women (65–74 years) only. The age and sex adjusted RR of the occurrence of IS in winter was 49% greater than in summer (95%CI 1–119%). When men and women were analyzed separately and the rates were adjusted for age, a significantly higher risk of IS was found only in men (RR = 2.48; 95% CI 1.27–4.83) in spring compared with summer. No seasonality was observed for the occurrence of SAH in both men and women. Our findings indicate that there is a significantly greater incidence of ischemic stroke during winter in Siberia, Russia, whereas the incidence of SAH does not show a seasonal variation.     

Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006

We studied 7 influenza (H5N1) viruses isolated from poultry in western Siberia and the European part of the Russian Federation during July 2005-February 2006. Full genome sequences showed high homology to Qinghai-like influenza (H5N1) viruses. Phylogenetic analysis not only showed a close genetic relationship between the H5N1 strains isolated from poultry and wild migratory waterfowls but also suggested genetic reassortment among the analyzed isolates. Analysis of deduced amino acid sequences of the M2 and neuraminidase proteins showed that all isolates are potentially sensitive to currently available antiviral drugs. Pathogenicity testing showed that all studied viruses were highly pathogenic in chickens; for 3 isolates tested in mice and 2 tested in ferrets, pathogenicity was heterogeneous. Pathogenicity in mammalian models was generally correlated with Lys at residue 627 of polymerase basic protein 2.     

Narratives from caregivers of children surviving the terrorist attack in Beslan: issues of health, culture, and resilience

Acts of terrorism have an extremely negative impact on the mental health of children and families. The school siege in Beslan, Russia, in 2004, represents a particularly traumatizing event as it was directed specifically at children and involved the entire community. This qualitative study aims to: (a) examine caregiver reactions to the terrorist attack in Beslan as reported 3 months after the traumatic event; (b) determine the extent to which indigenous cultural values and religious belief systems play a role in Beslan's caregivers' reactions to such event; and (c) identify variables that may function as sources of resilience to caregivers. A convenience sample of 17 primary caregivers from Beslan with at least one child who survived the school siege were asked to participate in semi-structured interviews. Narratives generated from the interviews were qualitatively analyzed using a thematic approach; nine major themes were identified. Caregivers' concerns centered on children's physical and psychological well-being, the reorganization of family life, and the disruption of community ties. Cultural values of pride, heroism, courage, and revenge emerged as relevant aspects shaping caregivers' reactions to the traumatic event. Possible sources of resilience included the willingness to return to normality, social support, and the reaffirmation of positive, culturally shared values in face of the perceived threat of future terrorist attacks. Findings are discussed in terms of their theoretical implications on the effects of trauma on children and families as well as interventions with highly traumatized populations in diverse cultural settings.     

The health implications of civic association in Russia

Can civic and political participation influence health outcomes, and if so, does the general aversion to joining community activities have some connection to poor health outcomes in Russia? Using data from surveys of 18,000+ urban Russians conducted from 2003 to 2005 and controlling for a wide range of variables, we find that individuals who join collective civic and political activities report better health than non-joiners and that living in a participatory community may enhance one’s health, regardless of one’s own participation.     

The Influence of Gender on Factors Associated with HIV Transmission Risk Among Young Russian Injection Drug Users

HIV infection rates are dramatically increasing in the Russian Federation. Epidemiological studies indicate that the greatest rise of HIV incidence has been among injection drug users (IDU). Young adults (N = 188) who reported injecting drug use completed surveys and interviews that assessed injection drug use behavior, sexual behavior, and HIV‐related knowledge. The average age of participants was 21.3 years. Multiple linear regression analysis found male gender and younger age at sexual debut was positively and significantly associated with having multiple sexual partners. Gender moderated the effects of sexual debut and number of times injected drugs were used in the past month. Males who initiate sex at a younger age were more likely to report multiple sex partners and females who reported higher frequency of drug use were more likely to report multiple sex partners. Gender is an important factor, as well as moderator of risk behavior among Russian injection drug users. Delaying sexual debut, particularly for males, may be an effective strategy to reduce subsequent risk behavior. Prevention efforts among IDUs need to address sexual risk behavior in conjunction with injection risk behavior.     

Asymptomatic cervical artery stenoses in Moscow

The risk of stroke related to asymptomatic carotid artery stenosis is known to be increased in high-grade or rapidly progressive stenosis. Information of the prevalence in the general population is required for the recommendation of screening methods to detect patients needing prophylactic treatment. We studied the prevalence and the grade of severity of extracranial carotid and vertebral artery obstructions by means of Doppler sonography in 529 asymptomatic Russians (m: 343, f: 186; 36-84 years, mean: 58.4 years) living in Moscow city. Internal carotid artery obstructions of more than 50% stenosis were present in 22 (=4.2%) subjects, 8 of them (1.5%) had bilateral lesions. Appropriate abnormal findings in vertebral arteries were found in 11 (=2.1%) subjects, in 1 of them bilaterally. Affection of both the carotid and the vertebral arteries was noted in 4 (=0.8%) individuals. There were no sexual differences. The risk factor which correlated most significantly with cervical arterial lesions was hypertension. Carotid lesions were also significantly associated with age and smoking, but not with diabetes or hyperlipoproteinemia. The prevalence of cervical artery stenoses was found to be lower than in western reports, which may be due to different technical equipment and different study design.