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61.
D. Caroline Blanchard Jon K. Shepherd R. J. Rodgers Robert J. Blanchard 《Psychopharmacology》1992,106(4):531-539
The Proxemics/Activity test and the Eat/Drink test, two components of the Anxiety/Defense Test Battery, were developed to measure defensive reactions to situations associated with a natural predator (cat). In the present studies the behavioral effects of 8-OH-DPAT treatment (0.01–1.0 mg/kg, SC) were entirely consistent with anxiety/fear reduction. These effects included an increase in time spent near the cat compartment, and a complimentary decrease in time spent farthest from this compartment, together with an increase in transits and locomote behavior. 8-OH-DPAT (1.0 mg/kg) also increased eat frequencies and durations (highly preferred food) both during and following cat presentation, without influencing drinking. This finding is discussed with reference to previous findings with 8-OH-DPAT in studies assessing both food intake and anxiolysis. Interestingly, 8-OH-DPAT was more potent in a majority of its effects in female subjects, a finding consistent with recent neurochemical data. These findings provide important behavioral evidence for a sexual differentiation in 5-HT function, and support the case for greater emphasis on female subjects in animal models of anxiety.Supported by NIH MH42803 and RCMI Grants RR03061 and RR01825 相似文献
62.
Cardia: study design, recruitment, and some characteristics of the examined subjects 总被引:28,自引:0,他引:28
Gary D. Friedman Gary R. Cutter Richard P. Donahue Glenn H. Hughes Stephen B. Hulley David R. Jacobs Jr. Kiang Liu Peter J. Savage 《Journal of clinical epidemiology》1988,41(11):1105-1116
In 1984, a prospective cohort study, Coronary Artery Risk Development in Young Adults (CARDIA) was initiated to investigate life-style and other factors that influence, favorably and unfavorably, the evolution of coronary heart disease risk factors during young adulthood. After a year of planning and protocol development, 5,116 black and white women and men, age 18-30 years, were recruited and examined in four urban areas: Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota, and Oakland, California. The initial examination included carefully standardized measurements of major risk factors as well as assessments of psychosocial, dietary, and exercise-related characteristics that might influence them, or that might be independent risk factors. This report presents the recruitment and examination methods as well as the mean levels of blood pressure, total plasma cholesterol, height, weight and body mass index, and the prevalence of cigarette smoking by age, sex, race and educational level. Compared to recent national samples, smoking is less prevalent in CARDIA participants, and weight tends to be greater. Cholesterol levels are representative and somewhat lower blood pressures in CARDIA are probably, at least in part, due to differences in measurement methods. Especially noteworthy among several differences in risk factor levels by demographic subgroup, were a higher body mass index among black than white women and much higher prevalence of cigarette smoking among persons with no more than a high school education than among those with more education. 相似文献
63.
Lois Jackson Wayne Putnam Peter Twohig Frederick Burge Kelly Nicol Jafna Cox 《Health, risk & society》2004,6(3):239-255
The management of patients through the use of evidence-based medicine has become the 'mantra' of medicine within many Western countries. Evidence-based medicine is aimed at providing the best objective, scientific care to all patients, and reducing as far as possible patients' risks of disease and complications from disease. Based on family physicians' discussions of the use of evidence-based recommendations for two cardiac diseases, this paper explores how subjectively-based trust enters into family physicians' decision to use evidence-based medicine. In addition, we show how trust influences physicians' work of recommending evidence-based medicine to patients, and physicians' perceptions of why patients follow recommendations aimed at risk reduction. We conclude that although much of the current discussion about evidence-based medicine assumes a 'rational' model of physician behaviour based on the application of the 'best objective scientific' results, subjectively-based perceptions of trust influence physician practices, and point to the need to understand the power of relational issues in influencing physician practices even when utilizing evidence-based knowledge. 相似文献
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目的:探讨常见呼吸道发热疾病的临床特点及与传染性非典型肺炎(严重急性呼吸综合症,SAGS)的鉴别。方法:发热门诊诊治的以发热体温高于38℃伴呼吸道症状患者702例,对病因、临床表现、实验室检查、胸部X线、治疗及转归进行比较。结果:常见呼吸道发热患者中,急性上呼吸道感染596例占总数的85%,577病例白细胞计数不高占82%,淋巴细胞计数不降低,X线检查正常或仅有支气管炎表现。有基础肺部或全身疾病患者,虽然有发热,但往往以肺部或全身原发疾病相应症状为重要或首发表现,可有气急,体温以中度发热为主,78%病例有白细胞计数及中性比例升高。胸片除肺炎改变外,多有肺部基础疾病的表现,抗生素治疗有效;而单纯性肺炎胸部X线多表现为节段性或局灶性肺炎。这部分病例也以发热为主要或首发症状,一般表现为咳嗽、咳痰,气急少见,易与SARS混淆。结论:临床呼吸道发热疾病以急性上呼吸道感染最多见,容易忽略,要注意筛查。单纯性肺炎与SARS的鉴别,应结合流行病史、治疗反应及实验室检查结果进行。 相似文献
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目的:对1990年至2002年6月期间在各种刊物上发表的区域性卫生规划的论文进行分析。方法:采用文献分析法,对论文发表的刊物、时间、作者所在地和单位、论文的主题和类别进行分析。结果:论文发表的刊物主要是卫生管理类、卫生经济、卫生政策、卫生资源等国家级刊物;发表的年份主要集中在1998年以后的几年中;作者所在的地区以北京、上海和山东最多;作者的单位以卫生行政单位和大专院校居多;论文的主题是以卫生资源配置居多;论文的类别以描述性的分析最多,理论研究其次。结论:应加强对区域性卫生规划实施评价和卫生资源配置方法的研究,不断总结经验,进一步推动区域性卫生规划的开展。 相似文献
70.
重庆市城市居民原发性高血压的病例对照研究 总被引:2,自引:0,他引:2
本研究采用1:4配比的方法,收集了370例确诊高血压病例与1480例对照,进行了病例对照研究。经条件logistic回归模型分析发现与高血压有关的危险因素有以下五个:体重指数、吸烟年限、脉率、卫生知识水平和家族史。 相似文献